Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial.

We examined the effects of a 6-month randomized program of endurance training (n = 14), resistance training (n = 17), or control conditions (n = 20) on insulin sensitivity in nonobese, younger women (18-35 yr). To examine the possible mechanism(s) related to alterations in insulin sensitivity, we measured body composition, regional adiposity, and skeletal muscle characteristics with computed tomography. We observed no changes in total body fat, sc abdominal adipose tissue, or visceral adipose tissue with endurance or resistance training. Insulin sensitivity, however, increased with endurance training (pre, 421 +/- 107; post, 490 +/- 133 mg/min; P < 0.05) and resistance training (pre, 382 +/- 87; post, 417 +/- 89 mg/min; P = 0.06). When the glucose disposal rate was expressed per kg fat-free mass (FFM), the improved insulin sensitivity persisted in endurance-trained (pre, 10.5 +/- 2.7; post, 12.1 +/- 3.3 mg/min x kg FFM; P < 0.05), but not in resistance-trained (pre, 9.7 +/- 1.9; post, 10.2 +/- 1.8 mg/min x kg FFM; P = NS) women. Muscle attenuation ratios increased (P < 0.05) in both endurance- and resistance-trained individuals, but this was not related to changes in insulin sensitivity. Moreover, the change in insulin sensitivity was not related to the increased maximum aerobic capacity in endurance-trained women (r = 0.24; P = NS). We suggest that both endurance and resistance training improve glucose disposal, although by different mechanisms, in young women. An increase in the amount of FFM from resistance training contributes to increased glucose disposal probably from a mass effect, without altering the intrinsic capacity of the muscle to respond to insulin. On the other hand, endurance training enhances glucose disposal independent of changes in FFM or maximum aerobic capacity, suggestive of an intrinsic change in the muscle to metabolize glucose. We conclude that enhanced glucose uptake after physical training in young women occurs with and without changes in FFM and body composition.

[1]  D. Matthews,et al.  Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. , 2000, The Journal of clinical endocrinology and metabolism.

[2]  E. Poehlman,et al.  Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women. , 1999, Diabetes.

[3]  J. Després,et al.  Alterations in body weight and composition consequent to 20 wk of endurance training: the HERITAGE Family Study. , 1999, The American journal of clinical nutrition.

[4]  A. Shuldiner,et al.  Obesity-related phenotypes and the beta3-adrenoceptor gene variant in postmenopausal women. , 1999, Diabetes.

[5]  R R Wing,et al.  Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. , 1999, Diabetes.

[6]  E. Poehlman,et al.  Dvorak RV, DeNino WF, Ades PA, Poehlman ET. Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women. Diabetes 48: 2210-2214 , 1999 .

[7]  K. Silver,et al.  Trp64Arg Variant of theβ 3-Adrenoceptor and Insulin Resistance in Obese Postmenopausal Women1 , 1998 .

[8]  J. Widimský,et al.  Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus , 1998, Diabetes Care.

[9]  T. Valle,et al.  Aerobic Endurance Exercise or Circuit-Type Resistance Training for Individuals with Impaired Glucose Tolerance? , 1998, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[10]  B. Goodpaster,et al.  Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat , 1997, Diabetes.

[11]  S. Lillioja,et al.  Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action , 1997, Diabetes.

[12]  J. Goodman,et al.  Resistance and aerobic training in older men: effects on VO2peak and the capillary supply to skeletal muscle. , 1997, Journal of applied physiology.

[13]  R. Ross,et al.  Separate Associations Between Visceral and Subcutaneous Adipose Tissue Distribution, Insulin and Glucose Levels in Obese Women , 1996, Diabetes Care.

[14]  D L Rothman,et al.  Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. , 1996, The New England journal of medicine.

[15]  J. Wilmore.  Increasing physical activity: alterations in body mass and composition. , 1996, The American journal of clinical nutrition.

[16]  A. Tremblay,et al.  Effects of Exercise Training on Abdominal Obesity and Related Metabolic Complications , 1996, Sports medicine.

[17]  I. Sartori.  Increasing Prevalence of Overweight Among US Adults , 1996 .

[18]  A. Gardner,et al.  Physiological predictors of increasing total and central adiposity in aging men and women. , 1995, Archives of internal medicine.

[19]  F. Dela,et al.  Insulin-Stimulated Muscle Glucose Clearance in Patients With NIDDM: Effects of One-Legged Physical Training , 1995, Diabetes.

[20]  J. Henriksson,et al.  Influence of Exercise on Insulin Sensitivity , 1995, Journal of cardiovascular risk.

[21]  A. Goldberg,et al.  Effects of exercise training modality on glucose tolerance in men with abnormal glucose regulation. , 1994, International journal of sports medicine.

[22]  K. Flegal,et al.  Increasing Prevalence of Overweight Among US Adults: The National Health and Nutrition Examination Surveys, 1960 to 1991 , 1994 .

[23]  M. Goran,et al.  Effects of endurance training on total fat oxidation in elderly persons. , 1994, Journal of applied physiology.

[24]  L. Groop,et al.  Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity. , 1993, The Journal of clinical investigation.

[25]  W. Kohrt,et al.  Endurance exercise training reduces glucose-stimulated insulin levels in 60- to 70-year-old men and women. , 1993, Journal of gerontology.

[26]  A. Goldberg,et al.  Aerobic versus strength training for risk factor intervention in middle-aged men at high risk for coronary heart disease. , 1993, Metabolism: clinical and experimental.

[27]  E. Horton,et al.  Glucose Transporter Number, Function, and Subcellular Distribution in Rat Skeletal Muscle After Exercise Training , 1992, Diabetes.

[28]  J. Bunt,et al.  Effects of arginine/lysine supplementation and resistance training on glucose tolerance. , 1992, Journal of applied physiology.

[29]  M. Goran,et al.  Influence of endurance training on energy intake, norepinephrine kinetics, and metabolic rate in older individuals. , 1992, Metabolism: clinical and experimental.

[30]  J. Albu,et al.  Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. , 1991, Journal of applied physiology.

[31]  P. Neufer,et al.  Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men. , 1991, The American journal of physiology.

[32]  E. Poehlman,et al.  Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals. , 1991, The American journal of physiology.

[33]  C. Bouchard,et al.  Loss of abdominal fat and metabolic response to exercise training in obese women. , 1991, The American journal of physiology.

[34]  M. Cerqueira,et al.  The effect of intensive endurance exercise training on body fat distribution in young and older men. , 1991, Metabolism: clinical and experimental.

[35]  M. Goran,et al.  The impact of physical activity and cold exposure on food intake and energy expenditure in man , 1990 .

[36]  L. Niskanen,et al.  5-year incidence of atherosclerotic vascular disease in relation to general risk factors, insulin level, and abnormalities in lipoprotein composition in non-insulin-dependent diabetic and nondiabetic subjects. , 1990, Circulation.

[37]  M. IUusitupa,et al.  5-year incidence of atherosclerotic vascular disease in relation to general risk factors, insulin level, and abnormalities in lipoprotein composition in non-insulin-dependent diabetic and nondiabetic subjects. , 1990 .

[38]  B. Craig,et al.  The influence of high-resistance training on glucose tolerance in young and elderly subjects , 1989, Mechanisms of Ageing and Development.

[39]  R P Tonino,et al.  Effect of physical training on the insulin resistance of aging. , 1989, The American journal of physiology.

[40]  R. DeFronzo,et al.  Effect of Physical Training on Insulin Action in Obesity , 1987, Diabetes.

[41]  A Cederblad,et al.  Determination of total adipose tissue and body fat in women by computed tomography, 40K, and tritium. , 1986, The American journal of physiology.

[42]  W. M. Sherman,et al.  Effect of strength training on glucose tolerance and post-glucose insulin response. , 1984, Medicine and science in sports and exercise.

[43]  M. Trovati,et al.  Influence of Physical Training on Blood Glucose Control, Glucose Tolerance, Insulin Secretion, and Insulin Action in Non-insulin-dependent Diabetic Patients , 1984, Diabetes Care.

[44]  P. Tesch,et al.  Muscle capillary supply and fiber type characteristics in weight and power lifters. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[45]  R. DeFronzo.  Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin , 1979, Diabetes.

[46]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.

[47]  J. Henriksson,et al.  Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise , 1977, The Journal of physiology.

[48]  J. Holloszy,et al.  Studies of tissue permeability. X. Changes in permeability to 3-methylglucose associated with contraction of isolated frog muscle. , 1965, The Journal of biological chemistry.