Flow injection analysis and biosensors: applications for biotechnology and environmental control.

Our experience in industrial bioprocess monitoring and environmental control let us develop a concept for biosensor research which distinguishes itself from other, more popular, approaches. Biosensors must improve and/or simplify existing state-of-the-art analysis systems. Only the parallel development of biosensors and their complementary metrology leads to industrially sound solutions. The combination of flow injection analysis with immobilized enzymes in the form of enzyme columns is already used today for the solution of on-line analytical problems in bioprocesses and environmental control.

[1]  Jennifer Van Brunt Biosensors for Bioprocesses , 1987, Bio/Technology.

[2]  Jaromír Růžička,et al.  Flow injection analysis — a survey of its potential for continuous monitoring of industrial processes , 1986 .

[3]  H. Lüdi,et al.  Flow-injection determination of proteins based on the lowry spectrophotometric method , 1989 .

[4]  N. F. Rooij,et al.  Fabrication and characterization of a planar electrochemical cell and its application as a glucose sensor , 1989 .

[5]  M Garn,et al.  A flow injection analysis system for fermentation monitoring and control , 1989, Biotechnology and bioengineering.

[6]  M. Küenzi,et al.  Biodegradation of chemical waste by specialized methylotrophs, an alternative to physical methods of waste disposal , 1985 .

[7]  E. Larson,et al.  Artificial reductant enhancement of the Lowry method for protein determination. , 1986, Analytical biochemistry.

[8]  M. Kula,et al.  Rapid on-line protein detection in biotechnological processes by flow injection analysis (FIA) , 1985 .

[9]  M. Gisin,et al.  Extensive flow-injection dilution for in-line sample pretreatment , 1988 .

[10]  Isao Karube,et al.  Integrated-circuit bio-calorimetric sensor for glucose , 1987 .

[11]  D. Clarke Biosensors in process control. , 1987, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[12]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[13]  B. Danielsson,et al.  Enzyme thermistor devices. , 1976, Methods in enzymology.

[14]  M. Gisin,et al.  Industrial process control by flow injection analysis , 1986 .

[15]  O. Ghisalba,et al.  Purification and characterization of N,N-dimethylformamidase from Pseudomonas DMF 3/3. , 1986, European journal of biochemistry.

[16]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.