Impaired sensory and motor differentiation with corpus callosum agenesis: A lack of callosal inhibition during ontogeny?

Abstract Congenital acallosals can make tactile discriminations with either hand, but neither hand is proficient in identifying the locus of a tactile stimulus or in performing independent finger movements. Intermanual transfer paralles intramanual perception, with disriminative but not topographic information being transferred from one hand to the other. An inhibitory action of the corpus callosum during ontogeny is essential, not for between-hand information transfer, but for the acquisition of differentiated sensation and movement within each hand.

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