Molecular Interaction of Serotonin 5-HT2A Receptor Residues Phe339(6.51) and Phe340(6.52) with Superpotent N-Benzyl Phenethylamine Agonists
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Michael R. Braden | David E Nichols | John C. Naylor | Michael R Braden | Jason C Parrish | John C Naylor | D. Nichols | J. C. Parrish
[1] H. Akil,et al. Hydrophobic Residues of the D2 Dopamine Receptor Are Important for Binding and Signal Transduction , 1995, Journal of neurochemistry.
[2] James J. Chambers,et al. A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor , 2002, J. Comput. Aided Mol. Des..
[3] C. Strader,et al. Identification of residues involved in ligand binding to the neurokinin-2 receptor. , 1995, Biochemistry.
[4] M. Brann,et al. Structure of a G-protein-coupling Domain of a Muscarinic Receptor Predicted by Random Saturation Mutagenesis (*) , 1996, The Journal of Biological Chemistry.
[5] D. E. Nichols,et al. Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats , 2002, Psychopharmacology.
[6] R J Leatherbarrow,et al. Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships. , 1987, Biochemistry.
[7] B. Roth,et al. A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors. , 1993, Molecular pharmacology.
[8] R. Glennon,et al. Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. , 1994, Journal of medicinal chemistry.
[9] J. Ballesteros,et al. A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice. , 1998, Biochemistry.
[10] B. Roth,et al. Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors. , 1997, Molecular pharmacology.
[11] Michael R. Braden,et al. C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. , 2006, Journal of medicinal chemistry.
[12] A. Shulgin,et al. PIHKAL: A Chemical Love Story , 1991 .
[13] R. Graham,et al. Phe310 in Transmembrane VI of the α1B-Adrenergic Receptor Is a Key Switch Residue Involved in Activation and Catecholamine Ring Aromatic Bonding* , 1999, The Journal of Biological Chemistry.
[14] J. Wess,et al. Identification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective coupling to PI turnover , 1989, FEBS letters.
[15] E. Hulme,et al. Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function. , 1999, Molecular pharmacology.
[16] B. Roth,et al. Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding. , 1995, Molecular pharmacology.
[17] J. Wess,et al. Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers. , 1990, Molecular pharmacology.
[18] H. Khorana,et al. Mapping of the amino acids in membrane-embedded helices that interact with the retinal chromophore in bovine rhodopsin. , 1991, The Journal of biological chemistry.
[19] Terrence P. Kenakin,et al. A Pharmacologic Analysis of Drug-Receptor Interaction , 1987 .
[20] J. Nardone,et al. Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[21] B. Roth,et al. Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. , 2000, Molecular pharmacology.
[22] J. Ballesteros,et al. [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors , 1995 .
[23] R. Leurs,et al. Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor* , 1999, The Journal of Biological Chemistry.
[24] T. Gallaher,et al. Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation. , 1993, Molecular pharmacology.
[25] V. Watts,et al. Serotonin 5-Hydroxytryptamine2A Receptor-Coupled Phospholipase C and Phospholipase A2 Signaling Pathways Have Different Receptor Reserves , 2003, Journal of Pharmacology and Experimental Therapeutics.
[26] Michael R. Braden,et al. 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. , 2006, Journal of medicinal chemistry.
[27] Michael R. Braden,et al. Differential phospholipase C activation by phenylalkylamine serotonin 5‐HT2A receptor agonists , 2005, Journal of neurochemistry.
[28] C. Gillberg,et al. Why Bother About Clumsiness? The Implications of Having Developmental Coordination Disorder (DCD) , 2003, Neural plasticity.
[29] A. Ashkenazi,et al. The Third Intracellular Loop of the 5‐Hydroxytryptamine2A Receptor Determines Effector Coupling Specificity , 1995, Journal of neurochemistry.
[30] William L. Jorgensen,et al. Aromatic-aromatic interactions: free energy profiles for the benzene dimer in water, chloroform, and liquid benzene , 1990 .
[31] H. Zhong,et al. Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes. , 1996, Molecular pharmacology.
[32] J. Nakai,et al. Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling , 1988, FEBS letters.
[33] B. Roth,et al. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism. , 2000, The Journal of pharmacology and experimental therapeutics.
[34] M. Kietzmann. Pharmacological analysis of drug-receptor interaction: Kenakin, T., 2nd Edn, XII + 483 pp. New York: Raven Press (1993) , 1994 .
[35] K. Minneman,et al. Inducible expression of alpha 1B-adrenoceptors in DDT1 MF-2 cells: comparison of receptor density and response. , 1995, European journal of pharmacology.
[36] J. Chambers,et al. Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity. , 2002, Bioorganic & medicinal chemistry letters.