Review of optical breast imaging and spectroscopy

Abstract. Diffuse optical imaging and spectroscopy of the female breast is an area of active research. We review the present status of this field and discuss the broad range of methodologies and applications. Starting with a brief overview on breast physiology, the remodeling of vasculature and extracellular matrix caused by solid tumors is highlighted that is relevant for contrast in optical imaging. Then, the various instrumental techniques and the related methods of data analysis and image generation are described and compared including multimodality instrumentation, fluorescence mammography, broadband spectroscopy, and diffuse correlation spectroscopy. We review the clinical results on functional properties of malignant and benign breast lesions compared to host tissue and discuss the various methods to improve contrast between healthy and diseased tissue, such as enhanced spectroscopic information, dynamic variations of functional properties, pharmacokinetics of extrinsic contrast agents, including the enhanced permeability and retention effect. We discuss research on monitoring neoadjuvant chemotherapy and on breast cancer risk assessment as potential clinical applications of optical breast imaging and spectroscopy. Moreover, we consider new experimental approaches, such as photoacoustic imaging and long-wavelength tissue spectroscopy.

[1]  F. M. van den Engh,et al.  Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics. , 2007, Optics express.

[2]  K. T. Moesta,et al.  Time-domain scanning optical mammography: II. Optical properties and tissue parameters of 87 carcinomas , 2005, Physics in medicine and biology.

[3]  Rakesh K. Jain,et al.  Pathology: Cancer cells compress intratumour vessels , 2004, Nature.

[4]  Brian W. Pogue,et al.  Predicting Breast Tumor Response to Neoadjuvant Chemotherapy with Diffuse Optical Spectroscopic Tomography prior to Treatment , 2014, Clinical Cancer Research.

[5]  V. Frattinia,et al.  Clinical approach with optical imaging instrument . Perspective analysis on 617 young females , 2011 .

[6]  O. Steinkellner,et al.  Development of a multi-channel time-domain fluorescence mammograph , 2007, SPIE BiOS.

[7]  Quing Zhu,et al.  Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria , 2014, Breast Cancer Research.

[8]  L. Tabár,et al.  Lightscanning versus mammography for the detection of breast cancer in screening and clinical practice. A Swedish multicenter study , 1990, Cancer.

[9]  B. Pogue,et al.  Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Alexander A. Oraevsky,et al.  Laser optoacoustic imaging of breast cancer in vivo , 2001, SPIE BiOS.

[11]  Alessandro Torricelli,et al.  Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography. , 2014, Biomedical optics express.

[12]  Doreen Steed,et al.  Dedicated 3D photoacoustic breast imaging. , 2013, Medical physics.

[13]  M. Menke-Pluymers,et al.  Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography. , 2004, Journal of biomedical optics.

[14]  H. Rieger,et al.  Integrative models of vascular remodeling during tumor growth , 2015, Wiley interdisciplinary reviews. Systems biology and medicine.

[15]  X. Intes.  Time-domain optical mammography SoftScan: initial results. , 2005, Academic radiology.

[16]  K. T. Moesta,et al.  Concentration and oxygen saturation of haemoglobin of 50 breast tumours determined by time-domain optical mammography. , 2004, Physics in medicine and biology.

[17]  Brian W Pogue,et al.  Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study. , 2010, Journal of biomedical optics.

[18]  Dirk Grosenick,et al.  Late-fluorescence mammography assesses tumor capillary permeability and differentiates malignant from benign lesions. , 2009, Optics express.

[19]  Peter Vajkoczy,et al.  EphB4 controls blood vascular morphogenesis during postnatal angiogenesis , 2006, The EMBO journal.

[20]  S. Arridge,et al.  Reconstruction of optical properties of phantom and breast lesion in vivo from paraxial scanning data , 2005, Physics in medicine and biology.

[21]  J. Ripoll,et al.  In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green. , 2003, Medical physics.

[22]  W. Totty,et al.  Light scanning versus mammography in breast cancer detection. , 1987, Radiology.

[23]  Thomas R. Cox,et al.  Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer , 2011, Disease Models & Mechanisms.

[24]  D. Cheresh,et al.  Tumor angiogenesis: molecular pathways and therapeutic targets , 2011, Nature Medicine.

[25]  Alessandro Torricelli,et al.  Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification. , 2009, Optics express.

[26]  P. Schlag,et al.  In-vivo tissue optical properties derived by linear perturbation theory for edge-corrected time-domain mammograms. , 2005, Optics express.

[27]  H. Rinneberg,et al.  Detection and characterization of breast tumours by time-domain scanning optical mammography , 2008 .

[28]  Dirk Grosenick,et al.  Breast cancer: early- and late-fluorescence near-infrared imaging with indocyanine green--a preliminary study. , 2011, Radiology.

[29]  Heidrun Wabnitz,et al.  Quantification of optical properties of a breast tumor using random walk theory. , 2002, Journal of biomedical optics.

[30]  M. Schweiger,et al.  Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography. , 2003, Optics letters.

[31]  K.,et al.  Frequency-domain optical mammography: edge effect corrections. , 1996, Medical physics.

[32]  Quing Zhu,et al.  Optical Tomography with Ultrasound Localization: Initial Clinical Results and Technical Challenges , 2005, Technology in cancer research & treatment.

[33]  M. Yaffe,et al.  Functional Imaging Using Diffuse Optical Spectroscopy of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer , 2010, Clinical Cancer Research.

[34]  Bin Deng,et al.  Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging. , 2015, Journal of biomedical optics.

[35]  A E Profio,et al.  Scientific basis of breast diaphanography. , 1989, Medical physics.

[36]  V. Marshall,et al.  Diaphanography as a means of detecting breast cancer. , 1984, Radiology.

[37]  Randall L Barbour,et al.  Digital optical tomography system for dynamic breast imaging. , 2011, Journal of biomedical optics.

[38]  P M Schlag,et al.  Development of a time-domain optical mammograph and first in vivo applications. , 1999, Applied optics.

[39]  A. Oraevsky,et al.  Laser optoacoustic imaging system for detection of breast cancer. , 2009, Journal of biomedical optics.

[40]  David Hsiang,et al.  Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy. , 2012, Cancer research.

[41]  A. Yodh,et al.  Diffuse optics for tissue monitoring and tomography , 2010, Reports on progress in physics. Physical Society.

[42]  S. Lorda,et al.  A systematic review of the effectiveness of magnetic resonance imaging ( MRI ) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer , 2007 .

[43]  Valerie M. Weaver,et al.  A tense situation: forcing tumour progression , 2009, Nature Reviews Cancer.

[44]  S Andersson-Engels,et al.  Changes in spectral shape of tissue optical properties in conjunction with laser-induced thermotherapy. , 1998, Applied optics.

[45]  Sandra K. Soho,et al.  Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. , 2004, Journal of biomedical optics.

[46]  Makoto Yamakawa,et al.  Characterization of photoacoustic tomography system with dual illumination , 2011, BiOS.

[47]  Sergio Fantini,et al.  Depth Discrimination in Diffuse Optical Transmission Imaging by Planar Scanning Off-Axis Fibers: INITIAL Applications to Optical Mammography , 2013, PloS one.

[48]  Lothar Lilge,et al.  Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk. , 2004, Journal of biomedical optics.

[49]  Gavin Thurston,et al.  Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system , 2009, Nature Reviews Molecular Cell Biology.

[50]  M. Cutler.  TRANSILLUMINATION OF THE BREAST , 1931, Annals of surgery.

[51]  Christopher Comstock,et al.  Near infrared transillumination imaging of breast cancer with vasoactive inhalation contrast. , 2010, Biomedical optics express.

[52]  T Nielsen,et al.  Investigation of detection limits for diffuse optical tomography systems: I. Theory and experiment. , 2009, Physics in medicine and biology.

[53]  E. Miller,et al.  Combined optical and X-ray tomosynthesis breast imaging. , 2011, Radiology.

[54]  B. Pogue,et al.  In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography. , 2010, Medical physics.

[55]  S. Fantini,et al.  Near-infrared spectral imaging of the female breast for quantitative oximetry in optical mammography. , 2009, Applied optics.

[56]  Peter Hauff,et al.  Comparison of Two Tricarbocyanine-Based Dyes for Fluorescence Optical Imaging , 2005, Journal of Fluorescence.

[57]  V. Ntziachristos,et al.  Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging. , 2003, Medical physics.

[58]  R. Jain,et al.  8 – Vascular and Interstitial Biology of Tumors , 2014 .

[59]  H. Maeda,et al.  Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[60]  H. Maeda,et al.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. , 1986, Cancer research.

[61]  Todd N. Erpelding,et al.  Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system , 2010, Biomedical optics express.

[62]  Jan Menke.  Photoacoustic breast tomography prototypes with reported human applications , 2015, European Radiology.

[63]  A. Purushotham,et al.  Monitoring the Response to Primary Medical Therapy for Breast Cancer Using Three-Dimensional Time-Resolved Optical Mammography , 2011, Technology in cancer research & treatment.

[64]  Alexander A. Oraevsky,et al.  “Contrast agents for optoacoustic imaging: design and biomedical applications” , 2015, Photoacoustics.

[65]  Sergio Fantini,et al.  Broadband Optical Mammography: Chromophore Concentration and Hemoglobin Saturation Contrast in Breast Cancer , 2015, PloS one.

[66]  Britton Chance,et al.  TIME-CORRELATED SINGLE PHOTON COUNTING IMAGER FOR SIMULTANEOUS MAGNETIC RESONANCE AND NEAR-INFRARED MAMMOGRAPHY , 1998 .

[67]  Valerie M. Weaver,et al.  The extracellular matrix at a glance , 2010, Journal of Cell Science.

[68]  A. Padhani,et al.  Dynamic optical breast imaging: a novel technique to detect and characterize tumor vessels. , 2009, European journal of radiology.

[69]  M. Schweiger,et al.  Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans. , 2007, Optics express.

[70]  K D Paulsen,et al.  Monitoring of hemodynamic changes induced in the healthy breast through inspired gas stimuli with MR-guided diffuse optical imaging. , 2010, Medical physics.

[71]  N F Schreiter,et al.  Fast 3D Near-infrared breast imaging using indocyanine green for detection and characterization of breast lesions. , 2011, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[72]  Soren D. Konecky,et al.  Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI. , 2005, Medical physics.

[73]  Jia Wang,et al.  MR Water Quantitative Priors Improves the Accuracy of Optical Breast Imaging , 2011, IEEE Transactions on Medical Imaging.

[74]  Paolo P. Provenzano,et al.  Collagen reorganization at the tumor-stromal interface facilitates local invasion , 2006, BMC medicine.

[75]  Brian W Pogue,et al.  Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging. , 2009, Applied optics.

[76]  Sergio Fantini,et al.  Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images. , 2004, Journal of biomedical optics.

[77]  C. D'Orsi,et al.  Diagnostic Performance of Digital Versus Film Mammography for Breast-Cancer Screening , 2005, The New England journal of medicine.

[78]  A. Godavarty,et al.  Hand-held based near-infrared optical imaging devices: a review. , 2009, Medical engineering & physics.

[79]  R. Greil,et al.  Neoadjuvant Chemotherapy and Targeted Therapy in Breast Cancer: Past, Present, and Future , 2013, Journal of oncology.

[80]  Yan Zhao,et al.  Direct regularization from co-registered anatomical images for MRI-guided near-infrared spectral tomographic image reconstruction. , 2015, Biomedical optics express.

[81]  Alessandro Torricelli,et al.  Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances , 2019 .

[82]  E. Miller,et al.  Tomographic optical breast imaging guided by three-dimensional mammography. , 2003, Applied optics.

[83]  Mark W. Dewhirst,et al.  Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response , 2008, Nature Reviews Cancer.

[84]  J. Folkman.  Tumor angiogenesis: therapeutic implications. , 1971, The New England journal of medicine.

[85]  N. Boyd,et al.  Mammographic density and breast cancer risk: current understanding and future prospects , 2011, Breast Cancer Research.

[86]  S. Arridge.  Optical tomography in medical imaging , 1999 .

[87]  P M Schlag,et al.  Contrast features of breast cancer in frequency-domain laser scanning mammography. , 1998, Journal of biomedical optics.

[88]  Quing Zhu,et al.  Estimation and imaging of breast lesions using a two-layer tissue structure by ultrasound-guided optical tomography , 2015, Journal of biomedical optics.

[89]  Wiendelt Steenbergen,et al.  Appearance of breast cysts in planar geometry photoacoustic mammography using 1064-nm excitation , 2013, Journal of biomedical optics.

[90]  B. Tromberg,et al.  Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy , 2007, Proceedings of the National Academy of Sciences.

[91]  Bo Qiang,et al.  Development of a handheld near-infrared imager for dynamic characterization of in vivo biological tissue systems. , 2007, Applied optics.

[92]  Richard J. Grable,et al.  Optical tomography breast imaging , 1997, Photonics West - Biomedical Optics.

[93]  Alessandro Torricelli,et al.  Effects of the Menstrual Cycle on the Red and Near-infrared Optical Properties of the Human Breast¶ , 2000, Photochemistry and photobiology.

[94]  Nola Hylton,et al.  Magnetic resonance imaging of the breast: opportunities to improve breast cancer management. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[95]  M. Elbiomy,et al.  Mammographic breast density: Predictive value for pathological response to neoadjuvant chemotherapy in breast cancer patients. , 2015, Breast.

[96]  Mitchell D. Schnall,et al.  Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors , 2014, PloS one.

[97]  F. M. van den Engh,et al.  Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology , 2015, Scientific Reports.

[98]  Sergio Fantini,et al.  Spatial and Spectral Information in Optical Mammography , 2005, Technology in cancer research & treatment.

[99]  K. Alitalo,et al.  Molecular regulation of angiogenesis and lymphangiogenesis , 2007, Nature Reviews Molecular Cell Biology.

[100]  P. Silcocks,et al.  What is the lifetime risk of developing cancer?: the effect of adjusting for multiple primaries , 2011, British Journal of Cancer.

[101]  David A. Boas,et al.  Compositional-prior-guided image reconstruction algorithm for multi-modality imaging , 2010, Biomedical optics express.

[102]  M. Coleman,et al.  The state of the art of cancer control in 30 European countries in 2008 , 2010, International journal of cancer.

[103]  Woo Kyung Moon,et al.  Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer , 2012, Breast Cancer Research.

[104]  P M Schlag,et al.  Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods. , 1998, Applied optics.

[105]  A. Gelfand,et al.  Predicting the cumulative risk of false-positive mammograms. , 2000, Journal of the National Cancer Institute.

[106]  Shoko Nioka,et al.  Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study. , 2006, Journal of biomedical optics.

[107]  Triantafyllos Stylianopoulos,et al.  Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors , 2012, Proceedings of the National Academy of Sciences.

[108]  Daniel Vanel,et al.  Dynamic optical breast imaging: a new technique to visualise breast vessels: comparison with breast MRI and preliminary results. , 2005, European journal of radiology.

[109]  B. Tromberg,et al.  Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study. , 2004, Journal of biomedical optics.

[110]  Bernhard Brendel,et al.  Investigation of detection limits for diffuse optical tomography systems: II. Analysis of slab and cup geometry for breast imaging. , 2009, Physics in medicine and biology.

[111]  Stephen P Povoski,et al.  A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions , 2007, Breast Cancer Research.

[112]  D. Boas,et al.  Haemoglobin oxygen saturation as a biomarker: the problem and a solution , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[113]  P M Schlag,et al.  Evaluation of higher-order time-domain perturbation theory of photon diffusion on breast-equivalent phantoms and optical mammograms. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[114]  M. Schweiger,et al.  Diffuse optical tomography with spectral constraints and wavelength optimization. , 2005, Applied optics.

[115]  Huabei Jiang,et al.  Noninvasive in vivo tomographic optical imaging of cellular morphology in the breast: possible convergence of microscopic pathology and macroscopic radiology. , 2008, Medical physics.

[116]  Zhixing Xie,et al.  Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry. , 2013, Ultrasound in medicine & biology.

[117]  U. P. S. T. Force,et al.  Chemoprevention of Breast Cancer: Recommendations and Rationale , 2002, Annals of Internal Medicine.

[118]  D. Boas,et al.  Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. , 2006, Journal of Biomedical Optics.

[119]  V. Ntziachristos,et al.  Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[120]  G. Yancopoulos,et al.  Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. , 1999, Science.

[121]  Jacqueline Gunther,et al.  Combined dynamic and static optical tomography for prediction of treatment outcome in breast cancer patients , 2015, European Conference on Biomedical Optics.

[122]  D. Miglioretti,et al.  Cumulative Probability of False-Positive Recall or Biopsy Recommendation After 10 Years of Screening Mammography , 2011, Annals of Internal Medicine.

[123]  Yaling Pei,et al.  Design and implementation of dynamic near-infrared optical tomographic imaging instrumentation for simultaneous dual-breast measurements. , 2005, Applied optics.

[124]  R. Cubeddu,et al.  Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm. , 2004, Journal of biomedical optics.

[125]  Brian W Pogue,et al.  In vivo near-infrared spectral detection of pressure-induced changes in breast tissue. , 2003, Optics letters.

[126]  M J Holboke,et al.  Three-dimensional diffuse optical mammography with ultrasound localization in a human subject. , 2000, Journal of biomedical optics.

[127]  D. Boas,et al.  Dynamic functional and mechanical response of breast tissue to compression. , 2008, Optics express.

[128]  Jennifer J. Gibson,et al.  Electromagnetic breast imaging: results of a pilot study in women with abnormal mammograms. , 2007, Radiology.

[129]  B. Pogue,et al.  Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction. , 2005, Applied optics.

[130]  B. Pogue,et al.  Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method. , 2010, Journal of biomedical optics.

[131]  Roy Bicknell,et al.  Tumour vascular targeting , 2005, Nature Reviews Cancer.

[132]  Alessandro Torricelli,et al.  Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy. , 2010, Journal of biomedical optics.

[133]  Hany Soliman,et al.  Diffuse optical spectroscopy evaluation of treatment response in women with locally advanced breast cancer receiving neoadjuvant chemotherapy. , 2012, Translational oncology.

[134]  H. Dvorak,et al.  Why are tumour blood vessels abnormal and why is it important to know? , 2009, British Journal of Cancer.

[135]  J. Brown,et al.  Exploiting tumour hypoxia in cancer treatment , 2004, Nature Reviews Cancer.

[136]  Triantafyllos Stylianopoulos,et al.  Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. , 2011, Annual review of chemical and biomolecular engineering.

[137]  B. Tromberg,et al.  Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. , 2007, Journal of biomedical optics.

[138]  N F Boyd,et al.  Growth factors and stromal matrix proteins associated with mammographic densities. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[139]  Marjolein van der Voort,et al.  A Novel Fluorescent Imaging Agent for Diffuse Optical Tomography of the Breast: First Clinical Experience in Patients , 2009, Molecular Imaging and Biology.

[140]  S. Colak,et al.  Clinical optical tomography and NIR spectroscopy for breast cancer detection , 1999 .

[141]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[142]  N. Boyd,et al.  Breast-tissue composition and other risk factors for breast cancer in young women: a cross-sectional study. , 2009, The Lancet. Oncology.

[143]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[144]  Intra-subject spatial changes in the optical properties of the female breast: A preliminary two-subject study , 2010 .

[145]  Bernhard Brendel,et al.  Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging , 2009, European Radiology.

[146]  Paola Taroni,et al.  Collagen content as a risk factor in breast cancer? A pilot clinical study , 2015, European Conference on Biomedical Optics.

[147]  Mitchell D. Schnall,et al.  Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures , 2015, Breast Cancer Research.

[148]  J. Mourant,et al.  Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms. , 1997, Applied optics.

[149]  Quing Zhu,et al.  Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound. , 2003, Optics letters.

[150]  Robert R. Alfano,et al.  Deep optical imaging of tissue using the second and third near-infrared spectral windows , 2014, Journal of biomedical optics.

[151]  B. Tromberg,et al.  Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment , 2011, Proceedings of the National Academy of Sciences.

[152]  Stanley J. Wiegand,et al.  Vascular-specific growth factors and blood vessel formation , 2000, Nature.

[153]  K. T. Moesta,et al.  Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients , 2005, Physics in medicine and biology.

[154]  Quing Zhu,et al.  Breast cancer: assessing response to neoadjuvant chemotherapy by using US-guided near-infrared tomography. , 2013, Radiology.

[155]  Enrico Gratton,et al.  Assessing tumor contrast in radiographically dense breast tissue using Diffuse Optical Spectroscopic Imaging (DOSI) , 2013, Breast Cancer Research.

[156]  Paola Taroni,et al.  Breast Tissue Composition and Its Dependence on Demographic Risk Factors for Breast Cancer: Non-Invasive Assessment by Time Domain Diffuse Optical Spectroscopy , 2015, PloS one.

[157]  Martin Schweiger,et al.  Three-dimensional time-resolved optical mammography of the uncompressed breast. , 2006, Applied optics.

[158]  L. Svaasand,et al.  Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. , 2000, Neoplasia.

[159]  Daniel Razansky,et al.  Portable spherical array probe for volumetric real-time optoacoustic imaging at centimeter-scale depths. , 2013, Optics express.

[160]  E. Cronin,et al.  Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis. , 2010, Radiology.

[161]  Xosé Luís Deán-Ben,et al.  Functional optoacoustic human angiography with handheld video rate three dimensional scanner☆ , 2013, Photoacoustics.

[162]  Z. Werb,et al.  Tumors as organs: complex tissues that interface with the entire organism. , 2010, Developmental cell.

[163]  H Rusinek,et al.  Fatty and fibroglandular tissue volumes in the breasts of women 20-83 years old: comparison of X-ray mammography and computer-assisted MR imaging. , 1997, AJR. American journal of roentgenology.

[164]  F. M. van den Engh,et al.  Visualizing breast cancer using the Twente photoacoustic mammoscope: what do we learn from twelve new patient measurements? , 2012, Optics express.

[165]  R Nossal,et al.  Time-dependent contrast functions for quantitative imaging in time-resolved transillumination experiments. , 1998, Applied optics.

[166]  R. Cubeddu,et al.  Characterization of female breast lesions from multi-wavelength time-resolved optical mammography , 2005, Physics in medicine and biology.

[167]  Alessandro Torricelli,et al.  Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media. , 2007, The Review of scientific instruments.

[168]  Brian W Pogue,et al.  Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo. , 2005, Journal of biomedical optics.

[169]  K. T. Moesta,et al.  Time-domain optical mammography: initial clinical results on detection and characterization of breast tumors. , 2003, Applied optics.

[170]  Thorsten Persigehl,et al.  Near-Infrared Imaging of the Breast Using Omocianine as a Fluorescent Dye: Results of a Placebo-Controlled, Clinical, Multicenter Trial , 2011, Investigative radiology.

[171]  Gary J. Whitman,et al.  Mammographic density and the risk of breast cancer recurrence after breast-conserving surgery , 2010 .

[172]  Soren D. Konecky,et al.  Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography. , 2009, Journal of biomedical optics.

[173]  Bruce J Tromberg,et al.  Diffuse optical imaging using spatially and temporally modulated light. , 2012, Journal of biomedical optics.

[174]  Dirk Grosenick,et al.  A multichannel time-domain scanning fluorescence mammograph: performance assessment and first in vivo results. , 2011, The Review of scientific instruments.

[175]  Yan Zhao,et al.  Optimization of image reconstruction for magnetic resonance imaging–guided near-infrared diffuse optical spectroscopy in breast , 2015, Journal of biomedical optics.

[176]  R. Cubeddu,et al.  Use of a nonlinear perturbation approach for in vivo breast lesion characterization by multiwavelength time-resolved optical mammography. , 2003, Optics express.

[177]  B. Pogue,et al.  Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes. , 2009, Radiology.

[178]  L. Fajardo,et al.  Differentiation of cysts from solid tumors in the breast with diffuse optical tomography. , 2004, Academic radiology.

[179]  J J Gisvold,et al.  Comparison of mammography and transillumination light scanning in the detection of breast lesions. , 1986, AJR. American journal of roentgenology.

[180]  M. Huang,et al.  Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases. , 2003, Neoplasia.

[181]  Alessandro Torricelli,et al.  Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications. , 2007, Journal of biomedical optics.

[182]  Brian W. Pogue,et al.  Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[183]  E. Conant,et al.  Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study. , 2005, Academic radiology.

[184]  Rami Nachabé,et al.  Estimation of biological chromophores using diffuse optical spectroscopy: benefit of extending the UV-VIS wavelength range to include 1000 to 1600 nm , 2010, Biomedical optics express.

[185]  Andrea Chirico,et al.  The Dynamic Optical Breast Imaging in the Preoperative Workflow of Women with Suspicious or Malignant Breast Lesions: Development of a New Comprehensive Score , 2012, ISRN oncology.

[186]  Brian W Pogue,et al.  Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer? , 2011, Radiology.

[187]  B. Tromberg,et al.  Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods. , 2000, Applied optics.

[188]  T. Helbich,et al.  Characterization of Benign and Malignant Breast Lesions With Computed Tomography Laser Mammography (CTLM): Initial Experience , 2005, Investigative radiology.

[189]  B. Pogue,et al.  Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results. , 2003, Applied optics.

[190]  Dirk Grosenick,et al.  Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom. , 2009, Applied optics.

[191]  N F Boyd,et al.  Automated analysis of mammographic densities and breast carcinoma risk , 1997, Cancer.

[192]  W Steenbergen,et al.  Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging. , 2014, Optics express.

[193]  Lothar Lilge,et al.  Association between Transillumination Breast Spectroscopy and Quantitative Mammographic Features of the Breast , 2008, Cancer Epidemiology Biomarkers & Prevention.

[194]  P. Tracqui,et al.  Biophysical models of tumour growth , 2009 .

[195]  Sergio Fantini,et al.  Spatial second-derivative image processing: an application to optical mammography to enhance the detection of breast tumors. , 2003, Journal of biomedical optics.

[196]  G. E. Geslien,et al.  Transillumination in breast cancer detection: screening failures and potential. , 1985, AJR. American journal of roentgenology.

[197]  N. Hylton,et al.  MRI in breast cancer therapy monitoring , 2011, NMR in biomedicine.

[198]  Reinhard Niessner,et al.  Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations , 2010, Analytical and bioanalytical chemistry.

[199]  V. Ntziachristos,et al.  MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions. , 2002, Neoplasia.

[200]  D. Watmough.  Diaphanography: mechanism responsible for the images. , 1982, Acta radiologica. Oncology.

[201]  Paola Taroni,et al.  Optical discrimination between malignant and benign breast lesions , 2015, European Conference on Biomedical Optics.

[202]  B. Tromberg,et al.  In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy. , 2006, Journal of biomedical optics.

[203]  Andrew D. A. Maidment,et al.  Blood flow reduction in breast tissue due to mammographic compression. , 2014, Academic radiology.

[204]  Heidrun Wabnitz,et al.  Scanning Time-domain Optical Mammography: Detection and Characterization of Breast Tumors In Vivo , 2005, Technology in cancer research & treatment.

[205]  A E Profio,et al.  Spectral transmittance and contrast in breast diaphanography. , 1985, Medical physics.

[206]  C. Luparello,et al.  Aspects of Collagen Changes in Breast Cancer , 2013 .

[207]  K Paulsen,et al.  ACRIN 6691 monitoring and predicting breast cancer neoadjuvant chemotherapy response using diffuse optical spectroscopic imaging (DOSI). , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[208]  Bruce J. Tromberg,et al.  The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer , 2004, Disease markers.

[209]  Denis Wirtz,et al.  Hypoxia and the extracellular matrix: drivers of tumour metastasis , 2014, Nature Reviews Cancer.

[210]  Paola Taroni,et al.  Broadband (600–1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use , 2016, IEEE Journal of Selected Topics in Quantum Electronics.

[211]  Brian W. Pogue,et al.  MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI , 2015, Clinical Cancer Research.

[212]  V. McCormack,et al.  Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk: A Meta-analysis , 2006, Cancer Epidemiology Biomarkers & Prevention.

[213]  B. Pogue,et al.  Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast. , 2001, Radiology.

[214]  Boudewijn P F Lelieveldt,et al.  Optical Mammography Using Diffuse Optical Spectroscopy for Monitoring Tumor Response to Neoadjuvant Chemotherapy in Women with Locally Advanced Breast Cancer , 2014, Clinical Cancer Research.

[215]  Lothar Lilge,et al.  The Association between Breast Tissue Optical Content and Mammographic Density in Pre- and Post-Menopausal Women , 2015, PloS one.

[216]  S. Paik,et al.  Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[217]  David Hsiang,et al.  Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy. , 2010, Radiology.

[218]  M. Huang,et al.  Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction. , 2005, Radiology.

[219]  Eric L. Miller,et al.  Combined optical imaging and mammography of the healthy breast: Optical contrast derived from breast structure and compression , 2009, IEEE Transactions on Medical Imaging.

[220]  Alessandro Torricelli,et al.  Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions , 2005, Physics in medicine and biology.