Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross
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[1] E. Eicher,et al. Stimulation of growth in the little mouse. , 1976, The Journal of endocrinology.
[2] S. Holm. A Simple Sequentially Rejective Multiple Test Procedure , 1979 .
[3] R. Palmiter,et al. Regulation of insulin-like growth factor I gene expression by growth hormone. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[4] Claus Christiansen,et al. Diagnosis of Osteoporosis , 1992, Southern medical journal.
[5] L. Avery,et al. Ordering gene function: the interpretation of epistasis in regulatory hierarchies. , 1992, Trends in genetics : TIG.
[6] L. Donahue,et al. Genetic variability in adult bone density among inbred strains of mice. , 1996, Bone.
[7] S. Cummings,et al. Epidemiology and predictors of fractures associated with osteoporosis. , 1997, The American journal of medicine.
[8] L. Donahue,et al. Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities. , 1997, Bone.
[9] E. Orwoll,et al. Quantitative Trait Loci Affecting Peak Bone Mineral Density in Mice , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[10] G. Churchill,et al. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice , 1999, Mammalian Genome.
[11] C. Steppan,et al. Leptin is a potent stimulator of bone growth in ob/ob mice , 2000, Regulatory Peptides.
[12] R. Eastell,et al. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. , 2000, The Journal of clinical investigation.
[13] G. Churchill,et al. Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice. , 2000, Bone.
[14] Garth A. Gibson,et al. Canalization in evolutionary genetics: a stabilizing theory? , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.
[15] B. Garvik,et al. Principles for the Buffering of Genetic Variation , 2001, Science.
[16] L. Melton,et al. Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. , 2001, The Journal of clinical endocrinology and metabolism.
[17] E. Barrett-Connor,et al. Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. , 2001, JAMA.
[18] Gary D Bader,et al. Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants , 2001, Science.
[19] M. Bouxsein,et al. Congenic Mice Reveal Sex-Specific Genetic Regulation of Femoral Structure and Strength , 2003, Calcified Tissue International.
[20] K. Sjögren,et al. Effects of Liver‐Derived Insulin‐Like Growth Factor I on Bone Metabolism in Mice , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[21] S. Cummings,et al. Epidemiology and outcomes of osteoporotic fractures , 2002, The Lancet.
[22] Hao Wu,et al. R/qtl: QTL Mapping in Experimental Crosses , 2003, Bioinform..
[23] L. Donahue,et al. Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms. , 2003, Endocrinology.
[24] Greg Gibson,et al. Uncovering cryptic genetic variation , 2004, Nature Reviews Genetics.
[25] M. Bouxsein,et al. Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. , 2004, Bone.
[26] M. Newman,et al. Finding community structure in very large networks. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.
[27] Paul Shannon,et al. Derivation of genetic interaction networks from quantitative phenotype data , 2005, Genome Biology.
[28] Nengjun Yi,et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits , 2004, Nature Genetics.
[29] G. Church,et al. Modular epistasis in yeast metabolism , 2005, Nature Genetics.
[30] Eric E. Schadt,et al. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits , 2005 .
[31] E E Schadt,et al. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits , 2005, Nature Genetics.
[32] L. Raisz. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. , 2005, The Journal of clinical investigation.
[33] Gábor Csárdi,et al. The igraph software package for complex network research , 2006 .
[34] S. Ralston,et al. Genetic regulation of bone mass and susceptibility to osteoporosis. , 2006, Genes & development.
[35] G. Churchill,et al. Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[36] A. Fraser,et al. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways , 2006, Nature Genetics.
[37] C. Rosen,et al. Postnatal growth and bone mass in mice with IGF-I haploinsufficiency. , 2006, Bone.
[38] Martin S. Taylor,et al. Genome-wide genetic association of complex traits in heterogeneous stock mice , 2006, Nature Genetics.
[39] L. Donahue,et al. Genetic increase in serum insulin-like growth factor-I (IGF-I) in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-I exon 2 promoter. , 2006, Endocrinology.
[40] Ralph Müller,et al. Automated compartmental analysis for high-throughput skeletal phenotyping in femora of genetic mouse models. , 2007, Bone.
[41] U. Alon. Network motifs: theory and experimental approaches , 2007, Nature Reviews Genetics.
[42] C. Bunker,et al. Pleiotropy and Heterogeneity in the Expression of Bone Strength‐Related Phenotypes in Extended Pedigrees , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[43] Vesteinn Thorsson,et al. Prediction of phenotype and gene expression for combinations of mutations , 2007, Molecular systems biology.
[44] L. Donahue,et al. Genetic Dissection of Mouse Distal Chromosome 1 Reveals Three Linked BMD QTLs With Sex‐Dependent Regulation of Bone Phenotypes , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[45] L. Donahue,et al. Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2. , 2007, Molecular endocrinology.
[46] P. Schneider,et al. Ultrastructural Properties in Cortical Bone Vary Greatly in Two Inbred Strains of Mice as Assessed by Synchrotron Light Based Micro‐ and Nano‐CT , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[47] Hui Shen,et al. Epistatic Interactions between Genomic Regions Containing the COL1A1 Gene and Genes Regulating Osteoclast Differentiation may Influence Femoral Neck Bone Mineral Density , 2007, Annals of human genetics.
[48] Grant W. Brown,et al. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map , 2007, Nature.
[49] P. Xiao,et al. A whole genome linkage scan for QTLs underlying peak bone mineral density , 2008, Osteoporosis International.
[50] C. Ackert-Bicknell,et al. A Chromosomal Inversion within a Quantitative Trait Locus Has a Major Effect on Adipogenesis and Osteoblastogenesis , 2007, Annals of the New York Academy of Sciences.
[51] Ronald W. Davis,et al. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions , 2007, Nature Genetics.
[52] Daniel L. Koller,et al. Sex‐Specific Genetic Loci for Femoral Neck Bone Mass and Strength Identified in Inbred COP and DA Rats , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[53] Sarah L Burgess-Herbert,et al. Practical Applications of the Bioinformatics Toolbox for Narrowing Quantitative Trait Loci , 2008, Genetics.
[54] Annie E. Hill,et al. Resistance to diet-induced obesity in mice with a single substituted chromosome. , 2008, Physiological genomics.
[55] Annie E. Hill,et al. Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis , 2008, Proceedings of the National Academy of Sciences.
[56] P. Phillips. Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems , 2008, Nature Reviews Genetics.
[57] Daniel L. Koller,et al. Epistatic Effects Contribute to Variation in BMD in Fischer 344 × Lewis F2 Rats , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[58] Daniel L. Koller,et al. Linkage Screen for BMD Phenotypes in Male and Female COP and DA Rat Strains , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[59] Greg D. Gale,et al. A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci , 2009, Molecular Psychiatry.
[60] Sarah L Burgess-Herbert,et al. Effects of atherogenic diet on hepatic gene expression across mouse strains. , 2009, Physiological genomics.
[61] Greg Gibson,et al. Decanalization and the origin of complex disease , 2009, Nature Reviews Genetics.
[62] R. Salvatori,et al. Diseases associated with growth hormone-releasing hormone receptor (GHRHR) mutations. , 2009, Progress in molecular biology and translational science.
[63] T. Mackay,et al. Quantitative Trait Loci for Aggressive Behavior in Drosophila melanogaster , 2009, Genetics.
[64] S. Yakar,et al. Elevated Serum Levels of IGF-1 Are Sufficient to Establish Normal Body Size and Skeletal Properties Even in the Absence of Tissue IGF-1 , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[65] Gary D Bader,et al. The Genetic Landscape of a Cell , 2010, Science.
[66] Ben Lehner,et al. Molecular mechanisms of epistasis within and between genes. , 2011, Trends in genetics : TIG.
[67] Thomas M. Keane,et al. Mouse genomic variation and its effect on phenotypes and gene regulation , 2011, Nature.
[68] Eleazar Eskin,et al. Mouse Genome-Wide Association and Systems Genetics Identify Asxl2 As a Regulator of Bone Mineral Density and Osteoclastogenesis , 2011, PLoS genetics.
[69] R. Gibbs,et al. INAUGURAL ARTICLE by a Recently Elected Academy Member:Epistasis dominates the genetic architecture of Drosophila quantitative traits , 2012 .
[70] Casey S. Greene,et al. IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks , 2012, Nucleic Acids Res..
[71] Leonard McMillan,et al. High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population , 2012, Genetics.
[72] Michelle Hays,et al. Use of Pleiotropy to Model Genetic Interactions in a Population , 2012, PLoS genetics.
[73] M. Peters,et al. Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.
[74] D. Ruffoni,et al. High-throughput quantification of the mechanical competence of murine femora--a highly automated approach for large-scale genetic studies. , 2013, Bone.
[75] Joseph E. Powell,et al. Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data , 2013, PLoS genetics.
[76] B. Mitchell,et al. Clinical impact of recent genetic discoveries in osteoporosis , 2013, The application of clinical genetics.
[77] Wei Lu,et al. CAPE: An R Package for Combined Analysis of Pleiotropy and Epistasis , 2013, PLoS Comput. Biol..
[78] Joseph E. Powell,et al. Detection and replication of epistasis influencing transcription in humans , 2014, Nature.
[79] Judith A. Blake,et al. The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse , 2013, Nucleic Acids Res..
[80] Gregory W. Carter,et al. A Genetic Interaction Network Model of a Complex Neurological Disease , 2014, Genes, brain, and behavior.
[81] M. Budoff,et al. Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. , 2014, The Journal of clinical investigation.
[82] T. Mackay. Epistasis and quantitative traits: using model organisms to study gene–gene interactions , 2013, Nature Reviews Genetics.
[83] R Core Team,et al. R: A language and environment for statistical computing. , 2014 .
[84] Chris S. Haley,et al. Detecting epistasis in human complex traits , 2014, Nature Reviews Genetics.
[85] M. Budoff,et al. Bicc 1 is a genetic determinant of osteoblastogenesis and bone mineral density , 2014 .
[86] P. Visscher,et al. Nature Genetics Advance Online Publication , 2022 .
[87] T. Mackay,et al. Erratum to: Why epistasis is important for tackling complex human disease genetics , 2015, Genome Medicine.
[88] Christina Kluge,et al. Data Reduction And Error Analysis For The Physical Sciences , 2016 .