Stratum corneum moisturization at the molecular level.

[1]  K. Yüksel,et al.  Effects of aging and xerosis on the amino acid composition of human skin. , 1990, The Journal of investigative dermatology.

[2]  J. Mesquita‐Guimarães.  X-Linked Ichthyosis , 1981 .

[3]  P. Wertz,et al.  Linoleate-rich acylglucosylceramides of pig epidermis: structure determination by proton magnetic resonance. , 1985, Journal of lipid research.

[4]  N. Delapp,et al.  Biosynthesis of pyrrolidone carboxylic acid in hairless mouse epidermis. , 1977, The Journal of investigative dermatology.

[5]  T. Egelrud,et al.  Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation. , 1993, The Journal of investigative dermatology.

[6]  S. J. Chapman,et al.  Desmosomes, corneosomes and desquamation. An ultrastructural study of adult pig epidermis , 2004, Archives of Dermatological Research.

[7]  P. Wertz,et al.  Ceramidase activity in porcine epidermis , 1990, FEBS letters.

[8]  J. Barrett,et al.  Histidine-rich protein of the keratohyalin granules. Source of the free amino acids, urocanic acid and pyrrolidone carboxylic acid in the stratum corneum. , 1982, Biochimica et biophysica acta.

[9]  P. Elias,et al.  Structural and lipid biochemical correlates of the epidermal permeability barrier. , 1991, Advances in lipid research.

[10]  U. Kiistala,et al.  Quantitative analysis of epidermal lipids by thin-layer chromatography with special reference to seasonal and age variation. , 1967, Acta dermato-venereologica.

[11]  J. Strauss,et al.  The composition of the ceramides from human stratum corneum and from comedones. , 1985, The Journal of investigative dermatology.

[12]  G. Plewig,et al.  Exfoliative Cytology: Effects of the Seasons , 1983 .

[13]  P. Wertz,et al.  The time course of lipid biosynthesis in pig epidermis. , 1988, The Journal of investigative dermatology.

[14]  P. Steinert,et al.  Characterization of a class of cationic proteins that specifically interact with intermediate filaments. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[15]  I. Scott.  Alterations in the metabolism of filaggrin in the skin after chemical- and ultraviolet-induced erythema. , 1986, The Journal of investigative dermatology.

[16]  T. Egelrud,et al.  Evidence that cell shedding from plantar stratum corneum in vitro involves endogenous proteolysis of the desmosomal protein desmoglein I. , 1990, The Journal of investigative dermatology.

[17]  J. Crowe,et al.  Free fatty acid effects on leakage, phase properties and fusion of fully hydrated model membranes , 1989 .

[18]  C. Miller,et al.  Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). , 1990, The Journal of investigative dermatology.

[19]  Elias Pm,et al.  The mammalian cutaneous permeability barrier: defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition. , 1978 .

[20]  G. Piérard.  What Does “Dry Skin” Mean? , 1987, International journal of dermatology.

[21]  Preparation and characterization of a reconstituted stratum corneum film as a model membrane for skin transport , 2004, Archives of Dermatological Research.

[22]  P. Elias,et al.  Epidermal lipids, barrier function, and desquamation. , 1983, The Journal of investigative dermatology.

[23]  K. Resing,et al.  Independent regulation of two cytoplasmic processing stages of the intermediate filament-associated protein filaggrin and role of Ca2+ in the second stage. , 1993, The Journal of biological chemistry.

[24]  P. Wertz,et al.  Free sphingosines in porcine epidermis. , 1989, Biochimica et biophysica acta.

[25]  James T. Elder,et al.  Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin. , 1988, The Journal of investigative dermatology.

[26]  A Lundström,et al.  Stratum corneum chymotryptic enzyme: a proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation. , 1991, Acta dermato-venereologica.

[27]  E. H. Gans,et al.  Effect of lipids on the aggregation and permeability of human stratum corneum. , 1982, The Journal of investigative dermatology.

[28]  H. Maibach,et al.  Ethnic difference of varied stratum corneum function in relation to stratum corneum lipids , 1993 .

[29]  A. Balmain,et al.  Protein synthesis during fetal development of mouse epidermis. I. The appearance of "histidine-rich protein". , 1977, Developmental biology.

[30]  I. Scott.  Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis and the resulting accumulation of urocanic acid. , 1981, The Biochemical journal.

[31]  G. Imokawa,et al.  Selective recovery of deranged water-holding properties by stratum corneum lipids. , 1986, The Journal of investigative dermatology.

[32]  U. Siegenthaler,et al.  Studies on contact sensitivity to chromium in the guinea pig. The role of valence in the formation of the antigenic determinant. , 1983, The Journal of investigative dermatology.

[33]  C. Prottey.  ESSENTIAL FATTY ACIDS AND THE SKIN , 1976, The British journal of dermatology.

[34]  A M Kligman,et al.  Age-associated changes in stratum corneum lipids and their relation to dryness. , 1988, Dermatologica.

[35]  K. Feingold.  The regulation and role of epidermal lipid synthesis. , 1991, Advances in lipid research.

[36]  K. Holbrook,et al.  Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules. , 1985, The Journal of investigative dermatology.

[37]  A. Matoltsy,et al.  Studies of the epidermal water barrier. II. Investigation of the chemical nature of the water barrier. , 1968, The Journal of investigative dermatology.

[38]  T. Egelrud,et al.  The dependence of detergent-induced cell dissociation in non-palmo-plantar stratum corneum on endogenous proteolysis. , 1990, The Journal of investigative dermatology.

[39]  D. Downing,et al.  Inhibition of prostaglandin biosynthesis by eicosa-5,8,11,14-tetraynoic acid. , 1970, Biochimica et biophysica acta.

[40]  P. Wertz,et al.  Covalently bound lipids of human stratum corneum. , 1989, The Journal of investigative dermatology.

[41]  P. Elias,et al.  Membrane alterations during cornification of mammalian squamous epithelia: A freeze‐fracture, tracer, and thin‐section study , 1977, The Anatomical record.

[42]  P A Bowser,et al.  Isolation, barrier properties and lipid analysis of stratum compactum, a discrete region of the stratum corneum , 1985, The British journal of dermatology.

[43]  R. Marks,et al.  Age-Related Changes in Stratum Corneum, Structure and Function , 1983 .

[44]  P. Elias,et al.  Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin. , 1993, Archives of dermatology.

[45]  Gf Odland,et al.  The structure of the skin , 1991 .

[46]  P. Elias,et al.  The permeability barrier in mammalian epidermis , 1975, The Journal of cell biology.

[47]  P. Wertz,et al.  Free sphingosine in human epidermis. , 1990, The Journal of investigative dermatology.

[48]  A. Fulmer,et al.  Stratum corneum lipid abnormalities in surfactant-induced dry scaly skin. , 1986, The Journal of investigative dermatology.

[49]  C. Harding,et al.  Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. , 1986, Developmental biology.

[50]  S. White,et al.  Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. , 1991, The Journal of investigative dermatology.

[51]  M Kawashima,et al.  Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? , 1991, The Journal of investigative dermatology.

[52]  C. Harding,et al.  Studies on the synthesis and degradation of a high molecular weight, histidine-rich phosphoprotein from mammalian epidermis. , 1981, Biochimica et biophysica acta.

[53]  H. Tagami,et al.  Stratum corneum hydration and amino acid content in xerotic skin , 1989, The British journal of dermatology.

[54]  P. Wertz,et al.  Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis. , 1984, The Journal of investigative dermatology.

[55]  J. Harper,et al.  The quantification of free sphingosine in the stratum corneum of patients with hereditary ichthyosis , 1993, The British journal of dermatology.

[56]  M. Kawai,et al.  Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin , 2004, Archives of Dermatological Research.

[57]  P. Wertz,et al.  Ceramides of pig epidermis: structure determination. , 1983, Journal of lipid research.

[58]  C. Prottey.  Investigation of functions of essential fatty acids in the skin , 1977, The British journal of dermatology.

[59]  R O Potts,et al.  The influence of stratum corneum morphology on water permeability. , 1991, The Journal of investigative dermatology.

[60]  R. White,et al.  Location and nature of the epidermal permeability barrier , 1986, International journal of cosmetic science.

[61]  M. Fartasch,et al.  Structural relationship between epidermal lipid lamellae, lamellar bodies and desmosomes in human epidermis: an ultrastructural study , 1993, The British journal of dermatology.

[62]  U. Houtsmuller,et al.  Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. , 1985, Biochimica et biophysica acta.

[63]  J. Lévêque,et al.  Stratum corneum lipids in skin xerosis. , 1989, Dermatologica.

[64]  N. Delapp,et al.  Gamma glutamyl peptidase: a novel enzyme from hairless mouse epidermis. , 1988, The Journal of investigative dermatology.

[65]  I. H. Blank,et al.  Factors which influence the water content of the stratum corneum. , 1952, The Journal of investigative dermatology.

[66]  R. R. Brenner,et al.  POSITION OF EICOSATRIENOIC ACID IN THE PHOSPHATIDYLCHOLINE AND PHOSPHATIDYLETHANOLAMINE FROM RATS DEFICIENT IN ESSENTIAL FATTY ACIDS. , 1963, Biochimica et biophysica acta.

[67]  R. White,et al.  1-(3'-O-acyl)-beta-glucosyl-N-dihydroxypentatriacontadienoylsphingosine, a major component of the glucosylceramides of pig and human epidermis. , 1978, Biochimica et biophysica acta.

[68]  P. Wertz,et al.  Molecular models of the intercellular lipid lamellae in mammalian stratum corneum. , 1989, The Journal of investigative dermatology.

[69]  J. Lonsdale-Eccles,et al.  A phosphorylated keratohyalin-derived precursor of epidermal stratum corneum basic protein. , 1980, The Journal of biological chemistry.

[70]  G. Burr,et al.  Nutrition classics from The Journal of Biological Chemistry 82:345-67, 1929. A new deficiency disease produced by the rigid exclusion of fat from the diet. , 1929, Nutrition reviews.

[71]  E. Jellum,et al.  The concentration of pyroglutamic acid (2-pyrrolidone-5-carboxylic acid) in normal and psoriatic epidermis, determined on a microgram scale by gas chromatography. , 1973, Clinica chimica acta; international journal of clinical chemistry.

[72]  S. Rajaraman,et al.  Endogenous lectin from terminally differentiated epidermal cells. , 1986, Differentiation; research in biological diversity.

[73]  G. M. Gray,et al.  isolation and , 2022 .

[74]  G. Burr,et al.  ON THE NATURE AND RÔLE OF THE FATTY ACIDS ESSENTIAL IN NUTRITION , 1930 .

[75]  P. Wertz,et al.  Lipid composition of cohesive and desquamated corneocytes from mouse ear skin. , 1986, The Journal of investigative dermatology.

[76]  J. Barrett,et al.  Pyrrolidone carboxylic acid synthesis in guinea pig epidermis. , 1983, The Journal of investigative dermatology.

[77]  M. Iwamori,et al.  Activation of keratinization of keratinocytes from fetal rat skin with N-(O-linoleoyl) omega-hydroxy fatty acyl sphingosyl glucose (lipokeratinogenoside) as a marker of epidermis. , 1990, Biochemical and biophysical research communications.

[78]  C. Harding,et al.  Histidine-rich proteins (filaggrins): structural and functional heterogeneity during epidermal differentiation. , 1983, Journal of molecular biology.

[79]  P. Elias,et al.  Membrane structural alterations in murine stratum corneum: relationship to the localization of polar lipids and phospholipases. , 1988, The Journal of investigative dermatology.

[80]  B. Dale,et al.  Evidence of a precursor form of stratum corneum basic protein in rat epidermis. , 1979, Biochemistry.

[81]  F. Inagaki,et al.  Structure determination of glucosyl beta 1-N-(omega-O-linoleoyl)-acylsphingosines of human epidermis. , 1989, Journal of Biochemistry (Tokyo).

[82]  U. Houtsmuller,et al.  Effects of topical application of fatty acids. , 1981, Progress in lipid research.

[83]  J. Tabachnick,et al.  Studies on the biochemistry of epidermis. IV. The free amino acids, ammonia, urea, and pyrrolidone carboxylic acid content of conventional and germ-free albino guina pig epidermia. , 1970, The Journal of investigative dermatology.

[84]  P. Elias,et al.  Lamellar bodies as delivery systems of hydrolytic enzymes: Implications for normal and abnormal desquamation , 1992, The British journal of dermatology.

[85]  M. Press,et al.  Correction of the cutaneous manifestations of essential fatty acid deficiency in man by application of sunflower-seed oil to the skin. , 1975, The Journal of investigative dermatology.

[86]  P. Wertz,et al.  Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat. , 1983, Biochimica et biophysica acta.

[87]  R. White,et al.  Identification, isolation and characterization of epidermal lipids containing linoleic acid. , 1985, Biochimica et biophysica acta.

[88]  P. Elias,et al.  Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses. , 1992, The Journal of investigative dermatology.

[89]  G. Burch,et al.  DIFFERENTIAL ROLES OF LAYERS OF HUMAN EPIGASTRIC SKIN ON DIFFUSION RATE OF WATER , 1944 .

[90]  M. Williams,et al.  Lipids in normal and pathological desquamation. , 1991, Advances in lipid research.

[91]  T. Murozuka,et al.  Immunochemical comparison of histidine-rich protein in keratohyalin granules and cornified cells. , 1979, Biochimica et biophysica acta.

[92]  J. Strauss,et al.  Human stratum corneum polar lipids and desquamation , 2004, Archives of Dermatological Research.

[93]  S. Rajaraman,et al.  Glycoproteins modulate adhesion in terminally differentiated keratinocytes , 1988, Cell and Tissue Research.

[94]  M. Lindberg,et al.  Membrane-coating granules in "dry" non-eczematous skin of patients with atopic dermatitis. A quantitative electron microscopic study. , 1987, Acta dermato-venereologica.

[95]  R. Presland,et al.  Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus. , 1992, The Journal of biological chemistry.

[96]  P. Wertz,et al.  Acylglucosylceramides of pig epidermis: structure determination. , 1983, Journal of lipid research.

[97]  K. Holbrook,et al.  Assembly of stratum corneum basic protein and keratin filaments in macrofibrils , 1978, Nature.

[98]  P. Wertz,et al.  Composition and morphology of epidermal cyst lipids. , 1987, The Journal of investigative dermatology.

[99]  P. Wertz,et al.  Evidence that the corneocyte has a chemically bound lipid envelope. , 1987, The Journal of investigative dermatology.

[100]  J. Middleton.  THE MECHANISM OF WATER BINDING IN STRATUM CORNEUM , 1968, The British journal of dermatology.

[101]  I. Bernstein,et al.  Histidine-rich proteins as molecular markers of epidermal differentiation. , 1978, The Journal of biological chemistry.

[102]  P. Wertz,et al.  Glycolipids in mammalian epidermis: structure and function in the water barrier. , 1982, Science.

[103]  U. Houtsmuller.  Columbinic acid, a new type of essential fatty acid. , 1981, Progress in lipid research.

[104]  G. M. Gray,et al.  Lipid compositions of cells isolated from pig, human, and rat epidermis. , 1975, Journal of lipid research.

[105]  W. Idler,et al.  FURTHER CHARACTERIZATION OF BOVINE KERATOHYALIN , 1972, The Journal of cell biology.