Severity of AD/HD symptoms and efficiency of attentional resource allocation

This study investigated the mechanism that underlies the inefficient allocation of attentional resources in Attention-Deficit/Hyperactivity Disorder (AD/HD). The P300 event-related brain potential (ERP) was elicited from 24 healthy adults using a visual three-stimulus oddball paradigm (standard, 70%; target, 15%; non-target, 15%) and the degree of their AD/HD symptoms was assessed by using AD/HD symptom scales. Target stimulus was a circle and standard stimulus was an "X". Two task conditions were defined according to the non-target stimulus type (typical or novel): a triangle for the typical condition and colored non-repetitive novel stimuli for the novel condition. In both conditions, target and non-target elicited P300s. A ratio of non-target P300 to target P300 amplitude was used to assess the efficiency of attentional resource allocation; low ratio indicates the efficient allocation of attentional resource. The correlation analysis revealed a strong positive correlation between the AD/HD symptom score and the P300 amplitude ratio in the typical condition (r=.80), while only a weak positive correlation was observed in the novel condition (r=.23). The present study found that the commonality of task-relevant and task-irrelevant information, rather than the stimulus novelty of task-irrelevant information, induces the inefficient allocation of attentional resources in AD/HD.

[1]  R. Barry,et al.  Auditory event-related potentials to a two-tone discrimination paradigm in attention deficit hyperactivity disorder , 1996, Psychiatry Research.

[2]  Joel T. Nigg,et al.  Neuropsychologic Theory and Findings in Attention-Deficit/Hyperactivity Disorder: The State of the Field and Salient Challenges for the Coming Decade , 2005, Biological Psychiatry.

[3]  E. John,et al.  Evoked-Potential Correlates of Stimulus Uncertainty , 1965, Science.

[4]  T W Picton,et al.  The P300 Wave of the Human Event‐Related Potential , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[5]  I. Winkler,et al.  Involuntary Attention and Distractibility as Evaluated with Event-Related Brain Potentials , 2000, Audiology and Neurotology.

[6]  P. Holcomb,et al.  Auditory event-related potentials in attention and reading disabled boys. , 1986, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[7]  E Donchin,et al.  A metric for thought: a comparison of P300 latency and reaction time. , 1981, Science.

[8]  Jaap Oosterlaan,et al.  How specific is a deficit of executive functioning for Attention-Deficit/Hyperactivity Disorder? , 2002, Behavioural Brain Research.

[9]  J. Polich,et al.  P300 from one-, two-, and three-stimulus auditory paradigms. , 1996, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[10]  A. Kok.  On the utility of P3 amplitude as a measure of processing capacity. , 2001, Psychophysiology.

[11]  G. McCarthy,et al.  Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. , 1977, Science.

[12]  D. Friedman,et al.  The novelty P3: an event-related brain potential (ERP) sign of the brain's evaluation of novelty , 2001, Neuroscience & Biobehavioral Reviews.

[13]  R. Barry,et al.  A review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials , 2003, Clinical Neurophysiology.

[14]  J. Intriligator,et al.  On the relationship between background EEG and the P300 event-related potential , 1994, Biological Psychology.

[15]  C. Neumann,et al.  Inhibitory capacity in adults with symptoms of Attention Deficit/Hyperactivity Disorder (ADHD). , 2003, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[16]  J. McGough,et al.  Diagnostic controversies in adult attention deficit hyperactivity disorder. , 2004, The American journal of psychiatry.

[17]  Dc Washington.  Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. , 1994 .

[18]  J. Polich.  Detection of change : event-related potential and fMRI findings , 2003 .

[19]  P. Wender,et al.  The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. , 1993, The American journal of psychiatry.

[20]  E. Donchin,et al.  Performance of concurrent tasks: a psychophysiological analysis of the reciprocity of information-processing resources. , 1983, Science.

[21]  J. Polich,et al.  P300, probability, and the three-tone paradigm. , 1996, Electroencephalography and clinical neurophysiology.

[22]  J. Polich,et al.  Neuropsychology and neuropharmacology of P3a and P3b. , 2006, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[23]  H. Möller,et al.  The effect of the skull on event-related P300 , 2001, Clinical Neurophysiology.

[24]  Allen Azizian,et al.  Event-related potentials as an index of similarity between words and pictures. , 2005, Psychophysiology.

[25]  R. Barkley.  Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. , 1997, Psychological bulletin.

[26]  B. J. Casey,et al.  Differential patterns of striatal activation in young children with and without ADHD , 2003, Biological Psychiatry.

[27]  E. Courchesne,et al.  Stimulus novelty, task relevance and the visual evoked potential in man. , 1975, Electroencephalography and clinical neurophysiology.

[28]  J. Polich,et al.  Cognitive and biological determinants of P300: an integrative review , 1995, Biological Psychology.

[29]  E. Donchin,et al.  Spatiotemporal analysis of the late ERP responses to deviant stimuli. , 2001, Psychophysiology.

[30]  J. Rabe-Jabłońska,et al.  [Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders]. , 1993, Psychiatria polska.

[31]  Kevin R. Murphy,et al.  Attention-deficit hyperactivity disorder : a clinical workbook , 1991 .

[32]  J. Polich,et al.  Stimulus context determines P3a and P3b. , 1998, Psychophysiology.

[33]  N. Squires,et al.  Electrophysiological correlates of categorization: P300 amplitude as index of target similarity , 2006, Biological Psychology.

[34]  J. Polich,et al.  Auditory and visual P300 topography from a 3 stimulus paradigm , 1999, Clinical Neurophysiology.