Stem Cell Therapy for Bone and Cartilage Defects â Can Culture-expansion be Avoided?

Copyright: © 2014 Jones E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Skeletal tissues including bone and cartilage experience significant mechanical stresses following normal physical activity. In bone, resultant microcracks are continuously repaired as a result of coordinated activity of osteoblasts, their progenitors – multipotential stromal/stem cells (MSCs) and osteo clasts, the bone-resorbing cells [1]. Physiological cartilage repair mechanisms are less well understood, but could be potentially mediated by MSCs present in cartilage superficial layer [2,3], synovium [4,5] or synovial fluid [6,7].

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