Biosynthesis of methylmercury compounds by the intestinal flora of the rat.

The contents of the rat cecum and, to a lesser extent, those of the small intestine, synthesized methylmercury from mercuric chloride labeled with Hg 203 in vitro under aerobic or anaerobic conditions. The rate of formation was approximately 18 ng/g cecal contents/20 hr. The synthesis of methylmercury was inhibited by antibiotics and by filtration of the cecal contents through membrane filters, indicating that the bacterial flora of the gut participates in the reaction. Pure cultures of bacteria, isolated from the intestinal tract of the rat, could methylate mercuric chloride. It was estimated that the total amount of methylmercury synthesized from ingested inorganic mercury in man in approximately 400 ng/day.

[1]  S. Jensen,et al.  Biological Methylation of Mercury in Aquatic Organisms , 1969, Nature.

[2]  D. Burkitt,et al.  Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease. , 1972, Lancet.

[3]  B. Drasar.  Cultivation of anaerobic intestinal bacteria. , 1967, The Journal of pathology and bacteriology.

[4]  I. Rowland,et al.  The methylation of mercuric chloride by human intestinal bacteria , 1975, Experientia.

[5]  J. Wood,et al.  Synthesis of Methyl-mercury Compounds by Extracts of a Methanogenic Bacterium , 1968, Nature.

[6]  G. Westöö,et al.  Determination of methylmercury compounds in foodstuffs. I. Methylmercury compounds in fish, identification and determination. , 1966, Acta chemica Scandinavica.

[7]  N Imura,et al.  Chemical Methylation of Inorganic Mercury with Methylcobalaiin, a Vitamin B12 Analog , 1971, Science.

[8]  M. Yamada.  Formation of methylmercury compounds from inorganic mercury by Clostridium cochlearium , 1972 .

[9]  T. Clarkson.  Epidemiological and experimental aspects of lead and mercury contamination of food. , 1971, Food and cosmetics toxicology.

[10]  B. McBride,et al.  Biosynthesis and degradation of methylmercury in human faeces , 1975, Nature.

[11]  I. Ihse,et al.  Methylation of inorganic mercury in experimental jejunal blind-loop. , 1973, Scandinavian journal of gastroenterology.

[12]  J. O. Tatton,et al.  Pesticide residues in the total diet in England and Wales, 1966-1967. IV.-Mercury content of the total diet. , 1970 .

[13]  J. O. Snihs,et al.  Metabolism of methyl mercury (203Hg) compounds in man. , 1969, Archives of environmental health.

[14]  H. Neujahr,et al.  Methylation of mercury compounds by methylcobalamin. , 1971, Biochemistry.

[15]  I. Rowland.  Metabolism of di-(2-ethylhexyl) phthalate by the contents of the alimentary tract of the rat. , 1974, Food and cosmetics toxicology.

[16]  H. Smith,et al.  OBSERVATIONS ON THE FLORA OF THE ALIMENTARY TRACT OF ANIMALS AND FACTORS AFFECTING ITS COMPOSITION. , 1965, The Journal of pathology and bacteriology.

[17]  B. Drasar,et al.  CHAPTER 10 – The Significance of the Gut Flora in Safety Testing of Food Additives , 1970 .