Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
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K. Knobeloch | M. Prinz | Werner Müller | A. Dahl | U. Ravens | C. Günther | C. Poulet | R. Naumann | K. Frenzel | M. Lesche | S. Lienenklaus | N. Zeller | Axel Roers | R. Behrendt | A. Gerbaulet | Katrin Peschke | M. Achleitner | S. Ada | Kathrin Frenzel
[1] V. Hornung,et al. Human plasmacytoid dendritic cells elicit a Type I Interferon response by sensing DNA via the cGAS‐STING signaling pathway , 2016, European journal of immunology.
[2] Nan Yan,et al. Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice , 2015, The Journal of Immunology.
[3] M. Cancro,et al. Nucleic Acid–Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation , 2015, The Journal of Immunology.
[4] Zhijian J. Chen,et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases , 2015, Proceedings of the National Academy of Sciences.
[5] Elizabeth E Gray,et al. Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome , 2015, The Journal of Immunology.
[6] Y. Crow,et al. Aicardi–Goutières syndrome and the type I interferonopathies , 2015, Nature Reviews Immunology.
[7] Yanbin Zhang,et al. Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA* , 2015, The Journal of Biological Chemistry.
[8] T. Hollis,et al. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease , 2015, Proceedings of the National Academy of Sciences.
[9] A. Bowie,et al. DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease , 2015, Glia.
[10] Xiaoming Zhan,et al. MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses , 2014, Science.
[11] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[12] G. Barber,et al. Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING , 2014, The Journal of Immunology.
[13] V. D’Agati,et al. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus , 2014, The Journal of experimental medicine.
[14] Jonathan L. Schmid-Burgk,et al. TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner , 2014, The Journal of Immunology.
[15] C. Günther,et al. Deregulated type I IFN response in TREX1-associated familial chilblain lupus. , 2014, The Journal of investigative dermatology.
[16] C. Johansen,et al. Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA , 2014, The Journal of Immunology.
[17] A. Celada,et al. The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation , 2013, The Journal of Immunology.
[18] T. Luedde,et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation , 2013, Nature Neuroscience.
[19] Zhijian J. Chen,et al. Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects , 2013, Science.
[20] J. Rehwinkel,et al. SAMHD1-dependent retroviral control and escape in mice , 2013, Retrovirology.
[21] D. Bonthron,et al. SAMHD1‐dependent retroviral control and escape in mice , 2013, The EMBO journal.
[22] Werner Müller,et al. Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response , 2013, Cell reports.
[23] S. Zelenay,et al. Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage , 2013, Cell.
[24] Wei Shi,et al. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..
[25] Zhijian J. Chen,et al. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.
[26] A. Mildner,et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. , 2013, Immunity.
[27] D. Stetson,et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. , 2012, Immunity.
[28] M. Wabl,et al. An autoimmune disease prevented by anti-retroviral drugs , 2011, Retrovirology.
[29] M. Christmann,et al. Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage , 2010, Nucleic acids research.
[30] F. Watt,et al. Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis , 2010, Nature Protocols.
[31] Serban Nacu,et al. Fast and SNP-tolerant detection of complex variants and splicing in short reads , 2010, Bioinform..
[32] G. Barber,et al. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity , 2009, Nature.
[33] K. Rajewsky,et al. Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-β In Vivo1 , 2009, The Journal of Immunology.
[34] G. Barber,et al. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling , 2008, Nature.
[35] T. Heidmann,et al. Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity , 2008, Cell.
[36] B. Becher,et al. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. , 2008, Immunity.
[37] S. Pillai,et al. Peripheral B cell subsets. , 2008, Current opinion in immunology.
[38] D. Barnes,et al. Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease , 2007, Cell.
[39] James B. Mitchell,et al. Effects of Gamma Radiation on FcεRI and TLR-Mediated Mast Cell Activation1 , 2007, The Journal of Immunology.
[40] Jos Jonkers,et al. Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues. , 2007, Physiological genomics.
[41] J. Lieberman,et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus , 2007, Nature Genetics.
[42] B. Reizis,et al. Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen , 2007, The Journal of experimental medicine.
[43] J. Lieberman,et al. A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus , 2007, Journal of Molecular Medicine.
[44] V. Pascual,et al. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. , 2006, Immunity.
[45] D. Barnes,et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus , 2006, Nature Genetics.
[46] R. Braren,et al. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation , 2006, The Journal of cell biology.
[47] D. Barnes,et al. Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis , 2004, Molecular and Cellular Biology.
[48] G. Courtois,et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 , 2002, Nature.
[49] Dan J. Mazur,et al. Excision of 3′ Termini by the Trex1 and TREX2 3′→5′ Exonucleases , 2001, The Journal of Biological Chemistry.
[50] O. Kretz,et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety , 1999, Nature Genetics.
[51] V. Luria,et al. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase , 1998, Transgenic Research.
[52] B. A. French,et al. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. , 1997, The Journal of clinical investigation.
[53] K. Rajewsky,et al. B lymphocyte-specific, Cre-mediated mutagenesis in mice. , 1997, Nucleic acids research.
[54] G. Bishop,et al. CpG motifs in bacterial DNA trigger direct B-cell activation , 1995, Nature.
[55] U. Ravens,et al. Alpha adrenoceptor stimulation reduces outward currents in rat ventricular myocytes. , 1989, The Journal of pharmacology and experimental therapeutics.
[56] K. Hartmann,et al. Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation. , 2015, Methods in molecular biology.
[57] Wei Zhang,et al. Photosensitivity in rheumatic diseases. , 2004, The journal of investigative dermatology. Symposium proceedings.
[58] K. Rajewsky,et al. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. , 1995, Nucleic acids research.
[59] Excision of 3 * Termini by the Trex1 and TREX2 3 * 3 5 * Exonucleases CHARACTERIZATION OF THE RECOMBINANT PROTEINS* , 2022 .