Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans

Current implantable devices that allow for recording and stimulation of brain activity in humans are not inherently designed for research and thus lack programmable control and integration with wearable sensors. We developed a platform that enables wireless and programmable intracranial electroencephalographic recording and deep brain stimulation integrated with wearable technologies. This methodology, when used in freely moving humans with implanted neural devices, can provide an ecologically valid environment conducive to elucidating the neural mechanisms underlying naturalistic behaviors and developing viable therapies for neurologic and psychiatric disorders.

[1]  A. Benabid,et al.  Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. , 1987, Applied neurophysiology.

[2]  Ignatius McGovern,et al.  Pupil , 2016, The Medical journal of Australia.

[3]  Markus E. Testorf,et al.  Cognitive tasks and human ambulatory electrocorticography using the RNS System , 2019, Journal of Neuroscience Methods.

[4]  J. Gybels,et al.  Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder , 1999, The Lancet.

[5]  Georgia Ramantani,et al.  Correlation of invasive EEG and scalp EEG , 2016, Seizure.

[6]  Arne D. Ekstrom,et al.  Specific responses of human hippocampal neurons are associated with better memory , 2015, Proceedings of the National Academy of Sciences.

[7]  Zahra M. Aghajan,et al.  Theta Oscillations in the Human Medial Temporal Lobe during Real-World Ambulatory Movement , 2016, Current Biology.

[8]  Krishna V Shenoy,et al.  ERAASR: an algorithm for removing electrical stimulation artifacts from multielectrode array recordings , 2017, bioRxiv.

[9]  Josef Parvizi,et al.  Promises and limitations of human intracranial electroencephalography , 2018, Nature Neuroscience.

[10]  Jeannie-Marie S. Leoutsakos,et al.  A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease , 2016, Journal of Alzheimer's disease : JAD.

[11]  Andreas Bulling,et al.  Pupil: an open source platform for pervasive eye tracking and mobile gaze-based interaction , 2014, UbiComp Adjunct.

[12]  Amir Rastegarnia,et al.  Methods for artifact detection and removal from scalp EEG: A review , 2016, Neurophysiologie Clinique/Clinical Neurophysiology.

[13]  A. Schulze-Bonhage Brain stimulation as a neuromodulatory epilepsy therapy , 2017, Seizure.

[14]  A. Destée,et al.  Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. , 2005, The New England journal of medicine.

[15]  M. Zaitsev,et al.  Motion artifacts in MRI: A complex problem with many partial solutions , 2015, Journal of magnetic resonance imaging : JMRI.

[16]  Nicholas R. Hasulak,et al.  Hippocampal gamma predicts associative memory performance as measured by acute and chronic intracranial EEG , 2018, Scientific Reports.

[17]  K. Ressler,et al.  Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic , 2007, Nature Neuroscience.