T-cell antigen receptor expression in the thymus.

[1]  F. Alt,et al.  A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes , 1986, Nature.

[2]  J. Seidman,et al.  Identification of a putative second T-cell receptor , 1986, Nature.

[3]  J. Coligan,et al.  Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex , 1986, Nature.

[4]  P. Musiani,et al.  Proliferation of phenotypically immature human thymocytes with and without interleukin 2 receptors. , 1986, Journal of immunology.

[5]  E. Reinherz,et al.  The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[6]  E. Reinherz,et al.  Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes. , 1986, Science.

[7]  L. Hood,et al.  The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. , 1986, Annual review of immunology.

[8]  A. Weiss,et al.  The role of the T3/antigen receptor complex in T-cell activation. , 1986, Annual review of immunology.

[9]  H. Boehmer,et al.  Requirements for growth of immature thymocytes from fetal and adult mice in vitro , 1986, European journal of immunology.

[10]  M. Crumpton,et al.  Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[11]  P. Marrack,et al.  Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ , 1985, Cell.

[12]  M. Minden,et al.  Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor α-chain , 1985, Nature.

[13]  T. Mak,et al.  Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer , 1985, Nature.

[14]  E. Rothenberg,et al.  Differentiation and cell division in the mammalian thymus. , 1985, Developmental biology.

[15]  Mark M. Davis,et al.  Variability and repertoire size of T-cell receptor Vα gene segments , 1985, Nature.

[16]  T. Strom,et al.  The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1. , 1985, Journal of immunology.

[17]  M. Toribio,et al.  Interleukin 2 promotes growth and cytolytic activity in human T3+4-8- thymocytes. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[18]  E. Reinherz,et al.  Clonal analysis of B cell growth and differentiation activities induced from T lymphocytes upon triggering of T3-Ti and T11 pathways. , 1985, Journal of immunology.

[19]  B. Haynes,et al.  Human T cell antigen expression during the early stages of fetal thymic maturation. , 1985, Journal of immunology.

[20]  E. Reinherz,et al.  Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[21]  E. Gelfand,et al.  Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones , 1985, Nature.

[22]  L. Hood,et al.  The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments , 1985, Nature.

[23]  I. Trowbridge,et al.  Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor β-chain gene , 1985, Nature.

[24]  Mark M. Davis,et al.  Expression of genes of the T-cell antigen receptor complex in precursor thymocytes , 1985, Nature.

[25]  E. Reinherz,et al.  Molecular analysis of T cell receptor (Ti) variable region (V) gene expression. Evidence that a single Ti beta V gene family can be used in formation of V domains on phenotypically and functionally diverse T cell populations , 1985, The Journal of experimental medicine.

[26]  H. Snodgrass,et al.  Expression of T-cell antigen receptor genes during fetal development in the thymus , 1985, Nature.

[27]  M. Minden,et al.  Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[28]  J. Yagüe,et al.  Rearrangement of T-cell receptor beta-chain genes during T-cell development. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[29]  J. Allison,et al.  Identification of antigen receptor-associated structures on murine T cells , 1985, Nature.

[30]  J. Lowenthal,et al.  Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells , 1985, Nature.

[31]  S. Tonegawa,et al.  Developmental regulation of T-cell receptor gene expression , 1985, Nature.

[32]  E. Reinherz.  A molecular basis for thymic selection: regulation of T11 induced thymocyte expansion by the T3-Ti antigen/MHC receptor pathway. , 1985, Immunology today.

[33]  J. Imboden,et al.  Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores , 1985, The Journal of experimental medicine.

[34]  H. Oettgen,et al.  The T3/T cell receptor complex: antigenic distinction between the two 20‐kd T3 (T3‐delta and T3‐epsilon) subunits. , 1985, The EMBO journal.

[35]  J. Strominger,et al.  Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunit , 1985, Cell.

[36]  P. Golstein,et al.  Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester , 1985, Nature.

[37]  E. Reinherz,et al.  Production and characterization of antibody probes directed at constant regions of the α and β subunit of the human T cell receptor , 1985, European journal of immunology.

[38]  L. Hood,et al.  Diversity and structure of genes of the α family of mouse T-cell antigen receptor , 1985, Nature.

[39]  S. Tonegawa,et al.  Unusual organization and diversity of T-cell receptor a-chain genes , 1985, Nature.

[40]  S. Tonegawa,et al.  Limited diversity of the rearranged T-cell γ gene , 1985, Nature.

[41]  F. Alt.  Immunology: Exclusive immunoglobulin genes , 1984, Nature.

[42]  E. Reinherz,et al.  Genes encoding the Ti β subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression , 1984, Cell.

[43]  B. Fowlkes,et al.  Cell Surface Antigen Expression on Thymocytes: Development and Phenotypic Differentiation of Intrathymic Subsets , 1984, Immunological reviews.

[44]  K. Shortman,et al.  T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants , 1984, Immunological reviews.

[45]  Michael J. Berridge,et al.  Inositol trisphosphate, a novel second messenger in cellular signal transduction , 1984, Nature.

[46]  E. Reinherz,et al.  Homology of Ti α-subunit of a T-cell antigen–MHC receptor with immunoglobulin , 1984, Nature.

[47]  E. Reinherz,et al.  Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[48]  A. Weiss,et al.  Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line , 1984, The Journal of experimental medicine.

[49]  J. Freed,et al.  Immunoglobulin-like nature of the α-chain of a human T-cell antigen/MHC receptor , 1984, Nature.

[50]  Mark M. Davis,et al.  Structure, expression and divergence of T-cell receptor β-chain variable regions , 1984, Nature.

[51]  Mark M. Davis,et al.  A third type of murine T-cell receptor gene , 1984, Nature.

[52]  S. Tonegawa,et al.  A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes , 1984, Nature.

[53]  Y. Nishizuka.  Turnover of inositol phospholipids and signal transduction. , 1984, Science.

[54]  P. Marrack,et al.  The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells , 1984, Cell.

[55]  E. Reinherz,et al.  Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex , 1984, The Journal of experimental medicine.

[56]  Mark M. Davis,et al.  Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes , 1984, Nature.

[57]  J. Mclean,et al.  Identification of shared antigenic determinants of the putative human T lymphocyte antigen receptor , 1984, The Journal of experimental medicine.

[58]  Tak W. Mak,et al.  Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide , 1984, Cell.

[59]  F. Alt,et al.  Ordered rearrangement of immunoglobulin heavy chain variable region segments. , 1984, The EMBO journal.

[60]  L. Hood,et al.  The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene , 1984, Cell.

[61]  Mark M. Davis,et al.  Somatic recombination in a murine T-cell receptor gene , 1984, Nature.

[62]  B. Haynes,et al.  Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment , 1984, The Journal of experimental medicine.

[63]  G. Church,et al.  Genomic sequencing. , 1993, Methods in molecular biology.

[64]  Mark M. Davis,et al.  Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins , 1984, Nature.

[65]  E. Reinherz,et al.  Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[66]  Tak W. Mak,et al.  A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains , 1984, Nature.

[67]  J. Yagüe,et al.  Primary structure of human T-cell receptor α-chain , 1984, Nature.

[68]  S. Orkin,et al.  Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex , 1984, Nature.

[69]  S. Tonegawa,et al.  Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences , 1984, Nature.

[70]  E. Reinherz,et al.  Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes. , 1983, Science.

[71]  R. Germain,et al.  Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[72]  E. Reinherz,et al.  The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors , 1983, Cell.

[73]  E. Reinherz,et al.  Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen , 1983, The Journal of experimental medicine.

[74]  E. Reinherz,et al.  Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones , 1983, The Journal of experimental medicine.

[75]  E. Reinherz,et al.  Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor , 1983, Nature.

[76]  J. Borst,et al.  The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins. , 1983, The Journal of biological chemistry.

[77]  P. Marrack,et al.  The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody , 1983, The Journal of experimental medicine.

[78]  M. Loken,et al.  A clone-specific monoclonal antibody that inhibits cytolysis of a cytolytic T cell clone , 1983, The Journal of experimental medicine.

[79]  A. Kraft,et al.  Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane , 1983, Nature.

[80]  E. Reinherz,et al.  Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex , 1983, The Journal of experimental medicine.

[81]  J. Allison,et al.  Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. , 1982, Journal of immunology.

[82]  E. Reinherz,et al.  Acquisition of immune competence by a subset of human cortical thymocytes expressing mature T cell antigens. , 1982, Journal of immunology.

[83]  S. Mizel.  Interleukin l and T Cell Activation , 1982 .

[84]  H. Macdonald,et al.  Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of “mature” thymocytes as analyzed by monoclonal antibodies and flow microfluorometry , 1982, The Journal of experimental medicine.

[85]  L. Herzenberg,et al.  A human T lymphocyte differentiation marker defined by monoclonal antibodies that block E-rosette formation. , 1981, Journal of immunology.

[86]  M. Lipinski,et al.  Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man , 1981, The Journal of experimental medicine.

[87]  E. Jenkinson,et al.  Embryology of the lymphoid system. , 1981, Progress in allergy.

[88]  E. Reinherz,et al.  A monoclonal antibody blocking human T cell function , 1980, European journal of immunology.

[89]  E. Reinherz,et al.  Location of T cell and major histocompatibility complex antigens in the human thymus , 1980, The Journal of experimental medicine.

[90]  D. Longo,et al.  T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells , 1980, Nature.

[91]  Ellis L. Reinherz,et al.  The differentiation and function of human T lymphocytes , 1980, Cell.

[92]  I. Weissman,et al.  Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice , 1980, European journal of immunology.

[93]  J. D. De Mey,et al.  OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties. , 1980, Journal of immunology.

[94]  K. Shortman,et al.  The differentiation of T lymphocytes. V. Evidence for intrathymic death of most thymocytes. , 1979, Thymus.

[95]  P. Fink,et al.  The Influence of Thymus H‐2 Antigens on the Specificity of Maturing Killer and Helper Cells , 1978, Immunological reviews.

[96]  O. Stutman.  Intrathymic and Extrathymic T Cell Maturation , 1978, Immunological reviews.

[97]  R. Zinkernagel,et al.  On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? , 1978, The Journal of experimental medicine.

[98]  Irving L. Weissman,et al.  Development and Function of Subpopulations of Thymocytes and T Lymphocytes (Part 1 of 2) , 1976 .

[99]  H Cantor,et al.  Development and function of subpopulations of thymocytes and T lymphocytes. , 1976, Progress in allergy.

[100]  H. Mcdevitt,et al.  Histocompatibility-linked immune response genes. , 1972, Science.

[101]  R. Zinkernagel,et al.  Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system , 1974, Nature.

[102]  R. Aspinall,et al.  Renewal and fate in the mammalian thymus: Mechanisms and inferences of thymocytokinetics , 1972, European journal of immunology.

[103]  N. K. Jerne,et al.  The somatic generation of immune recognition , 1971, European journal of immunology.

[104]  M. Papiernik.  Correlation of lymphocyte transformation and morphology in the human fetal thymus. , 1970, Blood.