A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells.

[1]  K. Borden,et al.  Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? , 2010, Leukemia & lymphoma.

[2]  Ling Peng,et al.  Triazole nucleoside derivatives bearing aryl functionalities on the nucleobases show antiviral and anticancer activity. , 2010, Mini reviews in medicinal chemistry.

[3]  J. Neyts,et al.  S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus. , 2010, Bioorganic & medicinal chemistry letters.

[4]  J. Iovanna,et al.  N-aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer. , 2010, Bioorganic & medicinal chemistry letters.

[5]  K. Borden,et al.  Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer , 2009, Journal of oncology.

[6]  J. Iovanna,et al.  Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer. , 2009, Journal of medicinal chemistry.

[7]  J. Iovanna,et al.  Cu-mediated Selective N-arylation of Aminotriazole Acyclonucleosides , 2009 .

[8]  B. Leber,et al.  Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. , 2009, Blood.

[9]  N. Lemoine,et al.  Pancreatic cancer: molecular pathogenesis and new therapeutic targets , 2009, Nature Reviews Gastroenterology &Hepatology.

[10]  F. Rivera,et al.  Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy. , 2009, Cancer treatment reviews.

[11]  S. Maehara,et al.  Interferon-gamma down-regulates heat shock protein 27 of pancreatic cancer cells and helps in the cytotoxic effect of gemcitabine. , 2009, Pancreas.

[12]  J. Iovanna,et al.  Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity. , 2009, Journal of medicinal chemistry.

[13]  R. Berardi,et al.  Pancreatic cancer: progress in cancer therapy. , 2008, Critical reviews in oncology/hematology.

[14]  J. Neyts,et al.  Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication. , 2008, Bioorganic & medicinal chemistry letters.

[15]  Fanqi Qu,et al.  Bitriazolyl Acyclonucleosides with Antiviral Activity against Tobacco Mosaic Virus , 2008 .

[16]  Fanqi Qu,et al.  Synthesis of nucleoside analogues with aromatic systems appended on the triazole nucleobase , 2008 .

[17]  S. Maehara,et al.  Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. , 2007, International journal of oncology.

[18]  S. Simon,et al.  Hsp27 (HspB1) and αB‐crystallin (HspB5) as therapeutic targets , 2007 .

[19]  E. Rauzy,et al.  Synthesis of bitriazolyl nucleosides and unexpectedly different reactivity of azidotriazole nucleoside isomers in the Huisgen reaction. , 2007, Organic & biomolecular chemistry.

[20]  G. Quéléver,et al.  Direct synthesis of 5-aryltriazole acyclonucleosides via Suzuki coupling in aqueous solution , 2007 .

[21]  Q. Liao,et al.  Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus. , 2006, Bioorganic & medicinal chemistry letters.

[22]  E. Mini,et al.  Cellular pharmacology of gemcitabine. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[23]  E. Clercq,et al.  Acyclic nucleoside phosphonates: a key class of antiviral drugs , 2005, Nature Reviews Drug Discovery.

[24]  J. Hoofnagle,et al.  Mechanism of action of interferon and ribavirin in treatment of hepatitis C , 2005, Nature.

[25]  Fanqi Qu,et al.  PHOTOLABELING PROBES OF RIBAVIRIN AND EICAR , 2005, Nucleosides, nucleotides & nucleic acids.

[26]  Ling Peng,et al.  Synthesis of Bitriazolyl Compounds via Huisgen Reaction. , 2005 .

[27]  Fanqi Qu,et al.  Design, Synthesis, and Characterization of Photolabeling Probes for the Study of the Mechanisms of the Antiviral Effects of Ribavirin , 2004 .

[28]  C. Concannon,et al.  On the role of Hsp27 in regulating apoptosis , 2004, Apoptosis.

[29]  K. Schulze-Osthoff,et al.  Ribavirin and Alpha Interferon Enhance Death Receptor-Mediated Apoptosis and Caspase Activation in Human Hepatoma Cells , 2003, Antimicrobial Agents and Chemotherapy.

[30]  L. Agrofoglio,et al.  Palladium-assisted routes to nucleosides. , 2003, Chemical reviews.

[31]  E. Negishi,et al.  Palladium-catalyzed alkynylation. , 2003, Chemical reviews.

[32]  Michal Hocek.  Syntheses of Purines Bearing Carbon Substituents in Positions 2, 6 or 8 by Metal- or Organometal-Mediated C−C Bond-Forming Reactions , 2003 .

[33]  E. Negishi,et al.  Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives. , 2001, Organic letters.

[34]  L. Hertel,et al.  Action of 2',2'-difluorodeoxycytidine on DNA synthesis. , 1991, Cancer research.

[35]  D. J. Bauer,et al.  Modifications on the heterocyclic base of acyclovir: syntheses and antiviral properties. , 1985, Journal of medicinal chemistry.

[36]  R. J. Bauer,et al.  Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[37]  R. K. Robins,et al.  Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides , 1972 .

[38]  R. K. Robins,et al.  Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide , 1972, Science.