Diffuse large B‐cell lymphoma presenting as miller fisher syndrome

We report a patient with diffuse large B‐cell lymphoma (DLBCL) who initially presented as Miller Fisher syndrome (MFS) responsive to high‐dose immunoglobulin treatment. Detailed investigations for the recurrence of neurological symptoms revealed DLBCL that was responsive to chemotherapy. DLBCL should be considered in the differential diagnosis of patients with MFS who have worsening of their neurological condition after initial improvement with conventional therapy. Muscle Nerve 45: 138–143, 2011

[1]  P. Pytel,et al.  Disseminated intravascular large‐cell lymphoma with initial presentation mimicking Guillain–Barré syndrome , 2010, Muscle & nerve.

[2]  A. Carpentier,et al.  Cerebrospinal fluid study in paraneoplastic syndromes , 2009, Journal of Neurology, Neurosurgery & Psychiatry.

[3]  K. Hirata,et al.  Bickerstaff's brainstem encephalitis and Fisher syndrome form a continuous spectrum , 2008, Journal of Neurology.

[4]  S. Gentile,et al.  Miller Fisher syndrome associated with Burkitt's lymphoma , 2006, European journal of neurology.

[5]  P. V. van Doorn,et al.  Distinguishing acute-onset CIDP from Guillain–Barré syndrome with treatment related fluctuations , 2005, Neurology.

[6]  D. Karcher,et al.  Lymphoma and peripheral neuropathy: A clinical review , 2005, Muscle & nerve.

[7]  K. Jellinger,et al.  Involvement of the central nervous system in malignant lymphomas , 1976, Virchows Archiv A.

[8]  A. Fung,et al.  Magnetic resonance imaging of nerve root inflammation in the Guillain-Barré syndrome , 2004, Neuroradiology.

[9]  K. Oshimi,et al.  Multifocal motor neuropathy caused by a B‐cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b , 2003, British journal of haematology.

[10]  W. Bradley,et al.  Demyelinating neuropathy in diabetes mellitus. , 2002, Archives of neurology.

[11]  H. Jasin,et al.  Vasculitis and lymph op roliferative diseases , 1996 .

[12]  J. Sabourin,et al.  Inflammatory neuromuscular disorders associated with chronic lymphoid leukemia: Evidence for clonal B cells within muscle and nerve , 1996, Journal of the Neurological Sciences.

[13]  J. Vallat,et al.  Non-Hodgkin malignant lymphomas and peripheral neuropathies--13 cases. , 1995, Brain : a journal of neurology.

[14]  R. Hughes,et al.  Effects of Lymphoma on the Peripheral Nervous System , 1994, Journal of the Royal Society of Medicine.

[15]  D. Bates,et al.  Demyelinating neuropathy due to primary IgM kappa B cell lymphoma of peripheral nerve , 1987, Neurology.

[16]  B. Zweiman,et al.  Guillain‐Barré syndrome and Hodgkin's disease: Three cases with immunological studies , 1977, Annals of neurology.

[17]  M. Fisher An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia). , 1956, The New England journal of medicine.