Synthetic Strategies and Pharmacological Activities of Chromene and Its Derivatives: An Overview

[1]  M. Ghadermazi,et al.  New advances in catalytic performance of erbium‐folic acid‐coated CoFe 2 O 4 complexes for green one‐pot three‐component synthesis of pyrano[2,3‐ d ]pyrimidinone and dihydropyrano[3,2‐ c ]chromenes compounds in water , 2021 .

[2]  Anamika,et al.  Ferrocene-Functionalized Dithiocarbamate Zinc(II) Complexes as Efficient Bifunctional Catalysts for the One-Pot Synthesis of Chromene and Imidazopyrimidine Derivatives via Knoevenagel Condensation Reaction. , 2021, Inorganic chemistry.

[3]  Feng Sha,et al.  Concise Synthesis of Chromene/Chromane-Type Aryne Precursors and Their Applications. , 2021, The Journal of organic chemistry.

[4]  Monika Gupta,et al.  Hybrid ceria and chitosan supported nickel nanoparticles: A recyclable nanocatalytic system in the reduction of nitroarenes and the synthesis of benzopyran derivatives in green solvent , 2021 .

[5]  Guilherme A. M. Jardim,et al.  A green metal-free “one-pot” microwave assisted synthesis of 1,4-dihydrochromene triazoles , 2021, RSC advances.

[6]  S. Patil,et al.  Biowaste-Derived Heterogeneous Catalyst for the One-Pot Multicomponent Synthesis of Diverse and Densely Functionalized 2-Amino-4H-Chromenes , 2021 .

[7]  Dhurke Kashinath,et al.  Synthesis of 4 H ‐chromene‐isoxazole hybrids via ortho ‐hydroxy directing cyclization of isoxazole‐styrenes and Michael addition of imino‐chromenes in aqueous medium , 2021 .

[8]  T. Syrovets,et al.  Synthesis, Cytotoxic Activity, Crystal Structure, DFT Studies and Molecular Docking of 3-Amino-1-(2,5-dichlorophenyl)-8-methoxy-1H-benzo[f]chromene-2-carbonitrile , 2021, Crystals.

[9]  Nipun Patel,et al.  Highly efficient and green synthesis of spiro[indoline-3,9′-xanthene]trione and spiro[chromene-4,3′-indoline]-3-carbonitrile derivatives in water catalyzed by graphene oxide-supported dicationic ionic liquid , 2021, Research on Chemical Intermediates.

[10]  Layla A. Taib,et al.  Solvent‐free synthesis of compounds containing chromene core catalyzed by novel Brønsted acidic ionic liquids ‐ClO 4 , 2021 .

[11]  S. Patil,et al.  A synergetic role of Aegle marmelos fruit ash in the synthesis of biscoumarins and 2-amino-4H-chromenes , 2021, Research on Chemical Intermediates.

[12]  M. Ramana,et al.  Synthesis, Molecular Docking, In Vitro Anti-Bacterial, and Anti-Cancer Activities of Some Novel Oxo-Spiro Chromene Schiff’s Bases , 2021 .

[13]  C. Mukhopadhyay,et al.  Ultrasonication under catalyst-free condition: an advanced synthetic technique toward the green synthesis of bioactive heterocycles , 2021 .

[14]  D. Joshi,et al.  Facile Access to 3,4-Disubstituted 2H-Chromenes via Domino [4+2] Annulation , 2021 .

[15]  Shahrzad Abdolmohammadi,et al.  An Efficient Synthesis of Some New Chromene Derivatives Catalyzed by Ag2Cr2O7 Nanoparticles , 2020, Polycyclic Aromatic Compounds.

[16]  Zoleikha Hajizadeh,et al.  Green and eco-friendly mica/Fe3O4 as an efficient nanocatalyst for the multicomponent synthesis of 2-amino-4H-chromene derivatives , 2020, Green Chemistry Letters and Reviews.

[17]  M. Kamali SnCl2⋅2H2O catalyzed one-pot three components synthesis of pyrano[4,3-b]chromenes and chromeno[4,3-b]chromenes , 2020 .

[18]  I. Yavari,et al.  Choline chloride/pentaerythritol: a deep eutectic solvent for the synthesis of pyran and chromene derivatives , 2020, Journal of the Iranian Chemical Society.

[19]  Ahmed E. M. Mekky,et al.  Efficient synthesis and characterization of novel bis(chromenes) and bis(benzo[f]chromenes) linked to thiazole units , 2020, Synthetic Communications.

[20]  B. Maleki,et al.  Facile Protocol for the Synthesis of 2-Amino-4H-Chromene Derivatives using Choline Chloride/Urea , 2020 .

[21]  H. Madkour,et al.  Synthesis of new benzo[f]chromene-based heterocycles targeting anti-proliferative activity , 2020, Journal of the Iranian Chemical Society.

[22]  F. Behbahani,et al.  γ-Fe2O3@Si-(CH2)3@mel@(CH2)4SO3H as a magnetically bifunctional and retrievable nanocatalyst for green synthesis of benzo[c]acridine-8(9H)-ones and 2-amino-4H-chromenes , 2020 .

[23]  Anlian Zhu,et al.  Biocompatible Ionic Liquid Promote One-Pot Synthesis of 2-Amino-4H-Chromenes Under Ambient Conditions , 2020, Catalysis Letters.

[24]  Jintae Lee,et al.  2H/4H-Chromenes—A Versatile Biologically Attractive Scaffold , 2020, Frontiers in Chemistry.

[25]  Qiong Tang,et al.  One-Pot Access to Diverse Functionalized Pyran Annulated Heterocyclic Systems Using SCMNPs@BPy-SO3H as a Novel Magnetic Nanocatalyst , 2020 .

[26]  A. Maleki,et al.  Synthesis of Core‐Shell Magnetic Supramolecular Nanocatalysts based on Amino‐Functionalized Calix[4]arenes for the Synthesis of 4H ‐Chromenes by Ultrasonic Waves , 2020, ChemistryOpen.

[27]  Liu Zhang,et al.  Synthesis of substituted 2H‐chromenes catalyzed by lipase immobilized on magnetic multiwalled carbon nanotubes , 2020, Biotechnology and applied biochemistry.

[28]  A. Zare,et al.  Efficient production of 2-amino-4H-chromenes and 14-aryl-14H-dibenzo[a, j]xanthenes catalyzed by N, N-diethyl-N-sulfoethanaminium hydrogen sulfate , 2020 .

[29]  Bhimrao M. Patil,et al.  Averrhoa bilimbi in Organic Transformation:A Highly Efficient and Green Biosurfactant for the Synthesis of Multi-Functional Chromenes and Xanthenes , 2020, Current Science.

[30]  J. Przepiórski,et al.  Basic-carbon nanocatalysts in the efficient synthesis of chromene derivatives. Valorization of both PET residues and mineral sources , 2020 .

[31]  M. Alfaifi,et al.  In vitro anticancer activity of pyrano[3, 2-c]chromene derivatives with both cell cycle arrest and apoptosis induction , 2020, Medicinal Chemistry Research.

[32]  Z. Moussa,et al.  Synthesis, Biological Assessment, and Structure Activity Relationship Studies of New Flavanones Embodying Chromene Moieties , 2020, Molecules.

[33]  R. Kant,et al.  Design, synthesis and evaluation of 4H-Chromene-4-one analogues as potential Anti-bacterial and Anti-fungal agents , 2020 .

[34]  R. Ramesh,et al.  An Organocatalytic Cascade Synthesis of Diverse 1H-Pyrazolo[1,2-b]phthalazine-2-carboxamide,1H-Pyrazolo[1,2-b]phthalazine, 4H-Pyrano[2,3-c]pyrazole and 4H-Benzo[g]chromenes via Multicomponent Reactions , 2020 .

[35]  R. Baharfar,et al.  Fe3O4@SiO2@D-NHCS-Tr as Efficient and Reusable Catalyst for the Synthesis of indol-3-yl-4H-chromene via a Multi-Component Reaction Under Solvent-Free Conditions , 2020 .

[36]  A. Cahyana,et al.  The Utilization of Fe3O4 Nanocatalyst in Modifying Cinnamaldehyde Compound to Synthesis 2-Amino-4H-Chromene Derivative , 2020 .

[37]  Deepak R. Mishra,et al.  Microwave‐assisted rapid and efficient synthesis of chromene‐fused pyrrole derivatives through multicomponent reaction and evaluation of antibacterial activity with molecular docking investigation , 2020 .

[38]  M. Mphahlele,et al.  Exploring Biological Activity of 4-Oxo-4H-furo[2,3-h]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15 , 2019, Biomolecules.

[39]  Hany E. A. Ahmed,et al.  First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents. , 2019, Bioorganic chemistry.

[40]  A. Abd-El-Aziz,et al.  First Example of Cationic Cyclopentadienyliron Based Chromene Complexes and Polymers: Synthesis, Characterization, and Biological Applications , 2019, Journal of Inorganic and Organometallic Polymers and Materials.

[41]  B. Mirza,et al.  A Novel, Efficient, and Recoverable Basic Fe3O4@C Nano-Catalyst for Green Synthesis of 4H-Chromenes in Water via One-Pot Three Component Reactions , 2019, Polycyclic Aromatic Compounds.

[42]  Salehe Sabouri,et al.  Synthesis and In Vitro Antiproliferative Effects of New Dihydropyrano[3,2-b]Chromene Derivatives , 2019, Polycyclic Aromatic Compounds.

[43]  F. Shirini,et al.  A Facile Green Synthesis of Chromene Derivatives as Antioxidant and Antibacterial Agents Through a Modified Natural Soil , 2019, ChemistrySelect.

[44]  E. Ezzatzadeh,et al.  Four-component green synthesis of benzochromene derivatives using nano-KF/clinoptilolite as basic catalyst: study of antioxidant activity , 2019, Molecular Diversity.

[45]  F. Shirini,et al.  Poly(4-Vinylpyridine) (P4VPy): A Basic Catalyst for Facile Synthesis of Biscoumarin and Dihydropyrano[3,2-c]Chromene Derivatives in Aqueous Media , 2019, Polycyclic Aromatic Compounds.

[46]  A. Harrath,et al.  Three‐component, one‐pot synthesis of pyrano[3,2‐c]chromene derivatives catalyzed by ammonium acetate: Synthesis, characterization, cation binding, and biological determination , 2019 .

[47]  A. Sivakumar,et al.  An eco-friendly catalytic system for multicomponent, one-pot synthesis of novel spiro-chromeno indoline-triones and their anti-prostate cancer potentials evaluated via alkaline phosphatase inhibition mechanism. , 2018, Bioorganic chemistry.

[48]  S. Ahmadi,et al.  A Facile and Promising Synthetic Strategy toward Functionalized 2H-Chromenes from Aryl Propargyl Ethers. A Review , 2018, Organic Preparations and Procedures International.

[49]  Wen Yang,et al.  Asymmetric synthesis and biological evaluation of 3-nitro-2H-chromenes as potential antibacterial agents , 2018, Tetrahedron Letters.

[50]  F. Tavakoli,et al.  Recent Advances in the MCRs Synthesis of Chromenes: A Review , 2018, Current Organic Chemistry.

[51]  A. Abdelazeem,et al.  Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities. , 2018, European journal of medicinal chemistry.

[52]  Y. Uesawa,et al.  3-(E)-Styryl-2H-chromene derivatives as potent and selective monoamine oxidase B inhibitors. , 2018, Bioorganic chemistry.

[53]  Zhiye Hu,et al.  Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction. , 2018, Organic and biomolecular chemistry.

[54]  Suneel S. Dodamani,et al.  Green, unexpected synthesis of bis-coumarin derivatives as potent anti-bacterial and anti-inflammatory agents. , 2018, European journal of medicinal chemistry.

[55]  M. H. Elnagdi,et al.  Recent developments in the enantioselective synthesis of polyfunctionalized pyran and chromene derivatives , 2017 .

[56]  M. Amini,et al.  Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety. , 2017, Bioorganic & medicinal chemistry.

[57]  F. Sen,et al.  One-pot three-component synthesis of 2-Amino-4H-Chromene derivatives by using monodisperse Pd nanomaterials anchored graphene oxide as highly efficient and recyclable catalyst , 2017 .

[58]  A. Elwahy,et al.  Synthesis and Anti‐influenza Virus Activity of Novel bis(4H‐chromene‐3‐carbonitrile) Derivatives , 2017 .

[59]  D. Touboul,et al.  Regiospecific synthesis, antibacterial and anticoagulant activities of novel isoxazoline chromene derivatives , 2017 .

[60]  B. P. Repsold,et al.  Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease. , 2017, European journal of medicinal chemistry.

[61]  R. Azimi,et al.  Efficient synthesis of 9,10-dihydropyrano[2,3-h]chromene-2,8-dione derivatives in ionic liquid and the study of their antioxidant activity , 2017, Natural product research.

[62]  D. A. Abou El Ella,et al.  Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers. , 2016, European journal of medicinal chemistry.

[63]  A. Brito,et al.  Biological importance of structurally diversified chromenes. , 2016, European journal of medicinal chemistry.

[64]  V. Zarubaev,et al.  Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes. , 2016, Bioorganic & medicinal chemistry.

[65]  L. Saso,et al.  Medicinal Chemistry Research Antiproliferative and Antioxidative Effects of Novel Hydrazone Derivatives Bearing Coumarin and Chromene Moiety , 2022 .

[66]  A. Shafiee,et al.  Hetero-annulated coumarins as new AChE/BuChE inhibitors: synthesis and biological evaluation , 2016, Medicinal Chemistry Research.

[67]  Raman Sandhiya,et al.  Synthesis and antioxidant properties of novel 2H-chromene-3-carboxylate and 3-acetyl-2H-chromene derivatives , 2016 .

[68]  J. Muthukumaran,et al.  Synthesis, in vitro and in silico anti-proliferative activity of 4-aryl-4H-chromene derivatives , 2016, Medicinal Chemistry Research.

[69]  F. Hatamjafari Glutamic Acid as an Environmentally Friendly Catalyst for One-Pot Synthesis of 4H-Chromene Derivatives and Biological Activity , 2016 .

[70]  Manish P. Patel,et al.  PS-TBD triggered general protocol for the synthesis of 4H-chromene, pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities , 2016 .

[71]  Feng-Cheng Liu,et al.  Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives , 2016, Research on Chemical Intermediates.

[72]  Eugenia Marqués-López,et al.  Enantioselective Organocatalyzed Synthesis of 2-Amino-3-cyano-4H-chromene Derivatives , 2015, Symmetry.

[73]  H. Meshram,et al.  A simple and efficient one-pot synthesis of 2-alkyl/aryl/pyridyl substituted 2H-chromenes , 2015 .

[74]  J. Shim,et al.  Construction of Diverse and Functionalized 2H-Chromenes by Organocatalytic Multicomponent Reactions , 2015 .

[75]  D. Rawat,et al.  Facile construction of 3-indolochromenes and 3-indoloxanthenes via EDDF catalyzed one-pot three component reactions , 2015 .

[76]  B. Bruin,et al.  Catalytic Synthesis of 2H-Chromenes , 2015 .

[77]  A. Shafiee,et al.  Synthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2H-chromene derivatives as potent anti-breast cancer agents. , 2014, European journal of medicinal chemistry.

[78]  R. Pratap,et al.  Natural and synthetic chromenes, fused chromenes, and versatility of dihydrobenzo[h]chromenes in organic synthesis. , 2014, Chemical reviews.

[79]  Wenjian Tang,et al.  New 2H-chromene-3-carboxamide derivatives: design, synthesis and use as inhibitors of hMAO. , 2014, European journal of medicinal chemistry.

[80]  C. Ganesh Kumar,et al.  Synthesis of novel 1,2,3-triazole/isoxazole functionalized 2H-Chromene derivatives and their cytotoxic activity. , 2014, Bioorganic & medicinal chemistry letters.

[81]  蒋敏,et al.  Synthesis of 2,2-difluoro-2H-chromenes through the tandem reaction of ethyl 3-bromo-3,3-difluoropropionate with salicylaldehyde derivatives , 2013 .

[82]  S. M. Zachariah,et al.  PHARMACOLOGICAL ACTIVITIES OF CHROMENE DERIVATIVES: AN OVERVIEW , 2013 .

[83]  Ramin Miri,et al.  2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents. , 2013, European journal of medicinal chemistry.

[84]  K. Parang,et al.  4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities , 2012, DARU Journal of Pharmaceutical Sciences.

[85]  F. A. Amer,et al.  Synthesis and Antioxidant and Antitumor Activity of Novel Pyridine, Chromene, Thiophene and Thiazole Derivatives , 2012, Archiv der Pharmazie.

[86]  Arunasree M. Kalle,et al.  Ultrasound mediated catalyst free synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-ones leading to novel quinoline derivatives: their evaluation as potential anti-cancer agents. , 2012, Bioorganic & medicinal chemistry.

[87]  C. Conti,et al.  New 4H-chromen-4-one and 2H-chromene derivatives as anti-picornavirus capsid-binders. , 2010, Bioorganic & medicinal chemistry.

[88]  Kumudini M. Meepagala,et al.  New class of algicidal compounds and fungicidal activities derived from a chromene amide of Amyris texana. , 2010, Journal of agricultural and food chemistry.

[89]  Samaneh Heydari,et al.  Chromene‐Based Synthetic Chalcones as Potent Antileishmanial Agents: Synthesis and Biological Activity , 2010, Chemical biology & drug design.

[90]  S. Solujic,et al.  Design of Novel 4-Hydroxy-chromene-2-one Derivatives as Antimicrobial Agents , 2010, Molecules.

[91]  Philip D. Campbell,et al.  Synthesis of function-oriented 2-phenyl-2H-chromene derivatives using L-pipecolinic acid and substituted guanidine organocatalysts. , 2010, Tetrahedron letters.

[92]  Atul Kumar,et al.  Diversity oriented synthesis of benzoxanthene and benzochromene libraries via one-pot, three-component reactions and their anti-proliferative activity. , 2010, Journal of combinatorial chemistry.

[93]  Y. Mély,et al.  Efficient synthesis of ratiometric fluorescent nucleosides featuring 3-hydroxychromone nucleobases. , 2009 .

[94]  P. T. Perumal,et al.  Synthesis of Novel 3-Bromo-2H-chromene Derivatives: Palladium-Mediated IntramolecularCyclization of Aryl Propargyl Ethers , 2009 .

[95]  T. Evans,et al.  A Forward Chemical Screen Using Zebrafish Embryos with Novel 2‐Substituted 2H‐Chromene Derivatives , 2009, Chemical biology & drug design.

[96]  Yong Tang,et al.  Unexpected tandem ylide annulation reaction for controllable synthesis of 2H-chromenes and 4H-chromenes. , 2006, Organic letters.

[97]  Mohamed M. Abdulla,et al.  4‐Chloro‐2,2‐disubstituted Chromen‐3‐carboxaldehyde: Synthesis of some Fused Polycyclic Heterocycles as Anti‐inflammatory, Analgesic, Anticonvulsant, and Antiparkinsonian Agents , 2006, Archiv der Pharmazie.

[98]  W. V. Otterlo,et al.  Ring-closing metathesis for the synthesis of 2H- and 4H-chromenes , 2005 .

[99]  G. E. Ali,et al.  Synthesis and antimicrobial evaluation of naphtho[2,1-b]pyrano[2,3-d]pyrimidine and pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives. , 2004, Acta pharmaceutica.

[100]  S. Soignet,et al.  Risk/benefit profile of arsenic trioxide. , 2001, The oncologist.

[101]  Helen J. Mitchell,et al.  Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans , 2000 .

[102]  A. Henriques,et al.  Two chromene derivatives from Calyptranthes tricona. , 2000, Phytochemistry.

[103]  N. Chudgar,et al.  New fluorescent mesogens with benzopyran-4[H] one heterocyclic moiety , 1995 .

[104]  G. Trivedi,et al.  Synthesis of 2, 2-Dimethyl-2H-chromenes via a Palladium (II) Catalysed Reaction , 1990 .