Proton-transport mechanisms in cytochrome c oxidase revealed by studies of kinetic isotope effects.
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[1] A. Warshel,et al. Exploration of the cytochrome c oxidase pathway puzzle and examination of the origin of elusive mutational effects. , 2011, Biochimica et biophysica acta.
[2] J. Klinman. A new model for the origin of kinetic hydrogen isotope effects , 2010 .
[3] A. Johansson,et al. Variable proton-pumping stoichiometry in structural variants of cytochrome c oxidase. , 2010, Biochimica et biophysica acta.
[4] R. Gennis,et al. Properties of Arg481 mutants of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that neither R481 nor the nearby D-propionate of heme a3 is likely to be the proton loading site of the proton pump. , 2009, Biochemistry.
[5] R. Pomès,et al. Functional hydration and conformational gating of proton uptake in cytochrome c oxidase. , 2009, Journal of molecular biology.
[6] J. Koepke,et al. A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate. , 2008, Journal of molecular biology.
[7] R. Gennis,et al. Cytochrome c oxidase: exciting progress and remaining mysteries , 2008, Journal of bioenergetics and biomembranes.
[8] A. Stuchebrukhov,et al. Theoretical and computational analysis of the membrane potential generated by cytochrome c oxidase upon single electron injection into the enzyme. , 2008, Biochimica et biophysica acta.
[9] M. Wikström,et al. The proton donor for OO bond scission by cytochrome c oxidase , 2008, Proceedings of the National Academy of Sciences.
[10] Arieh Warshel,et al. Electrostatic basis for the unidirectionality of the primary proton transfer in cytochrome c oxidase , 2008, Proceedings of the National Academy of Sciences.
[11] P. Brzezinski,et al. Deuterium isotope effect of proton pumping in cytochrome c oxidase. , 2008, Biochimica et biophysica acta.
[12] M. Wikström,et al. Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases. , 2007, Biochimica et biophysica acta.
[13] A. Warshel,et al. Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase. , 2007, The journal of physical chemistry. B.
[14] V. Barone,et al. Effective method to compute vibrationally resolved optical spectra of large molecules at finite temperature in the gas phase and in solution. , 2007, The Journal of chemical physics.
[15] Gregory A. Voth,et al. Path‐Integral Centroid Methods in Quantum Statistical Mechanics and Dynamics , 2007 .
[16] Arieh Warshel,et al. Exploring pathways and barriers for coupled ET/PT in cytochrome c oxidase: a general framework for examining energetics and mechanistic alternatives. , 2007, Biochimica et biophysica acta.
[17] Jiali Gao,et al. A combined quantum mechanical and molecular mechanical study of the reaction mechanism and alpha-amino acidity in alanine racemase. , 2006, Journal of the American Chemical Society.
[18] Sharon Hammes-Schiffer,et al. Hybrid quantum/classical path integral approach for simulation of hydrogen transfer reactions in enzymes. , 2006, The Journal of chemical physics.
[19] A. Warshel,et al. Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.
[20] R. Gennis,et al. Transmembrane proton translocation by cytochrome c oxidase. , 2006, Biochimica et biophysica acta.
[21] P. Brzezinski,et al. Design principles of proton-pumping haem-copper oxidases. , 2006, Current opinion in structural biology.
[22] M. Wikström,et al. Towards the mechanism of proton pumping by the haem-copper oxidases. , 2006, Biochimica et biophysica acta.
[23] A. Warshel,et al. Dynamical Contributions to Enzyme Catalysis: Critical Tests of a Popular Hypothesis , 2006 .
[24] P. Adelroth,et al. Surface proton donors for the D-pathway of cytochrome c oxidase in the absence of subunit III. , 2006, Biochemistry.
[25] A. Warshel,et al. Electrostatic basis for enzyme catalysis. , 2006, Chemical reviews.
[26] S. Ferguson-Miller,et al. Energy transduction: proton transfer through the respiratory complexes. , 2006, Annual review of biochemistry.
[27] Arieh Warshel,et al. Monte Carlo simulations of proton pumps: on the working principles of the biological valve that controls proton pumping in cytochrome c oxidase. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[28] Weitao Yang,et al. Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: proton transfer in triosephosphate isomerase. , 2006, The Journal of chemical physics.
[29] R. Gennis,et al. Controlled uncoupling and recoupling of proton pumping in cytochrome c oxidase. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[30] P. Brzezinski,et al. The timing of proton migration in membrane-reconstituted cytochrome c oxidase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[31] P. Brzezinski,et al. A mechanistic principle for proton pumping by cytochrome c oxidase , 2005, Nature.
[32] R. Gennis,et al. Transmembrane Charge Separation during the Ferryl-oxo → Oxidized Transition in a Nonpumping Mutant of Cytochrome c Oxidase* , 2004, Journal of Biological Chemistry.
[33] S. Hammes-Schiffer,et al. Proton-coupled electron transfer in soybean lipoxygenase. , 2004, Journal of the American Chemical Society.
[34] M. Wikström. Cytochrome c oxidase: 25 years of the elusive proton pump. , 2004, Biochimica et biophysica acta.
[35] J. Hosler. The influence of subunit III of cytochrome c oxidase on the D pathway, the proton exit pathway and mechanism-based inactivation in subunit I. , 2004, Biochimica et biophysica acta.
[36] A. Warshel,et al. Simulations of the large kinetic isotope effect and the temperature dependence of the hydrogen atom transfer in lipoxygenase. , 2004, Journal of the American Chemical Society.
[37] A. Puustinen,et al. The catalytic cycle of cytochrome c oxidase is not the sum of its two halves. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[38] R. Gennis,et al. Redox-coupled proton translocation in biological systems: Proton shuttling in cytochrome c oxidase , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[39] M. Blomberg,et al. Theoretical Study of the Energetics of Proton Pumping and Oxygen Reduction in Cytochrome Oxidase , 2003 .
[40] P. Brzezinski,et al. Redox-driven proton pumping by heme-copper oxidases. , 2003, Biochimica et biophysica acta.
[41] P. Brzezinski,et al. Subunit III of cytochrome c oxidase of Rhodobacter sphaeroides is required to maintain rapid proton uptake through the D pathway at physiologic pH. , 2003, Biochemistry.
[42] S. Ferguson-Miller,et al. A role for subunit III in proton uptake into the D pathway and a possible proton exit pathway in Rhodobacter sphaeroides cytochrome c oxidase. , 2003, Biochemistry.
[43] A. Katsonouri,et al. Intramolecular proton-transfer reactions in a membrane-bound proton pump: the effect of pH on the peroxy to ferryl transition in cytochrome c oxidase. , 2003, Biochemistry.
[44] R. Gennis,et al. A Mutation in Subunit I of Cytochrome Oxidase from Rhodobacter sphaeroides Results in an Increase in Steady-State Activity but Completely Eliminates Proton Pumping† , 2002 .
[45] J. Klinman,et al. Environmentally coupled hydrogen tunneling , 2002 .
[46] E. Bamberg,et al. Reduction of cytochrome c oxidase by a second electron leads to proton translocation , 2002, Nature.
[47] A. Warshel,et al. Dynamics of biochemical and biophysical reactions: insight from computer simulations , 2001, Quarterly Reviews of Biophysics.
[48] P. Agarwal,et al. Hydride transfer in liver alcohol dehydrogenase: quantum dynamics, kinetic isotope effects, and role of enzyme motion. , 2001, Journal of the American Chemical Society.
[49] Manuela M. Pereira,et al. A novel scenario for the evolution of haem-copper oxygen reductases. , 2001, Biochimica et biophysica acta.
[50] S. Yoshikawa,et al. Reaction Mechanism of Bovine Heart Cytochrome c Oxidase , 2000 .
[51] A. Puustinen,et al. The role of the D- and K-pathways of proton transfer in the function of the haem-copper oxidases. , 2000, Biochimica et biophysica acta.
[52] R. Gennis,et al. Proton transfer from glutamate 286 determines the transition rates between oxygen intermediates in cytochrome c oxidase. , 2000, Biochimica et biophysica acta.
[53] E. Bamberg,et al. Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificans. , 2000, Biochemistry.
[54] P. Brzezinski,et al. Localized control of proton transfer through the D-pathway in cytochrome c oxidase: application of the proton-inventory technique. , 2000, Biochemistry.
[55] P. Brzezinski,et al. The onset of the deuterium isotope effect in cytochrome c oxidase. , 2000, Biochemistry.
[56] R. Gennis,et al. Mutations in the putative H-channel in the cytochrome c oxidase from Rhodobacter sphaeroides show that this channel is not important for proton conduction but reveal modulation of the properties of heme a. , 2000, Biochemistry.
[57] M. Bratton,et al. Suicide inactivation of cytochrome c oxidase: catalytic turnover in the absence of subunit III alters the active site. , 1999, Biochemistry.
[58] H. Michel,et al. Cytochrome c oxidase: catalytic cycle and mechanisms of proton pumping--a discussion. , 1999, Biochemistry.
[59] P. Brzezinski,et al. Factors determining electron-transfer rates in cytochrome c oxidase: investigation of the oxygen reaction in the R. sphaeroides enzyme. , 1998, Biochimica et biophysica acta.
[60] R. Gennis,et al. Single electron reduction of cytochrome c oxidase compound F: resolution of partial steps by transient spectroscopy. , 1998, Biochemistry.
[61] P. Brzezinski,et al. Pathways of Proton Transfer in Cytochrome c Oxidase , 1998, Journal of bioenergetics and biomembranes.
[62] S. Schwartz,et al. Large kinetic isotope effects in enzymatic proton transfer and the role of substrate oscillations. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[63] R. Gennis,et al. The roles of the two proton input channels in cytochrome c oxidase from Rhodobacter sphaeroides probed by the effects of site-directed mutations on time-resolved electrogenic intraprotein proton transfer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[64] M. Wikström,et al. Translocation of electrical charge during a single turnover of cytochrome-c oxidase , 1997 .
[65] Arieh Warshel,et al. How Important Are Quantum Mechanical Nuclear Motions in Enzyme Catalysis , 1996 .
[66] R. Gennis,et al. Rapid purification of wildtype and mutant cytochrome c oxidase from Rhodobacter sphaeroides by Ni2+‐NTA affinity chromatography , 1995, FEBS letters.
[67] A. Warshel,et al. Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches , 1993 .
[68] Arieh Warshel,et al. A Quantized Classical Path Approach for Calculations of Quantum Mechanical Rate Constants , 1993 .
[69] G. Babcock,et al. Oxygen activation and the conservation of energy in cell respiration , 1992, Nature.
[70] Arieh Warshel,et al. Computer Modeling of Chemical Reactions in Enzymes and Solutions , 1991 .
[71] Arieh Warshel,et al. Simulations of quantum mechanical corrections for rate constants of hydride-transfer reactions in enzymes and solutions , 1991 .
[72] J. Hynes,et al. Molecular‐dynamics simulation for a model nonadiabatic proton transfer reaction in solution , 1991 .
[73] A. Warshel,et al. Quantum corrections for rate constants of diabatic and adiabatic reactions in solutions , 1990 .
[74] G. Voth,et al. Rigorous formulation of quantum transition state theory and its dynamical corrections , 1989 .
[75] M J Gillan,et al. Quantum-classical crossover of the transition rate in the damped double well , 1987 .
[76] A. Warshel,et al. Simulation of the dynamics of electron transfer reactions in polar solvents: Semiclassical trajectories and dispersed polaron approaches , 1986 .
[77] Arieh Warshel,et al. Dynamics of reactions in polar solvents. Semiclassical trajectory studies of electron-transfer and proton-transfer reactions , 1982 .
[78] Richard Phillips Feynman,et al. Statistical Mechanics: A Set of Lectures , 1972 .
[79] James Hemp,et al. Diversity of the heme-copper superfamily in archaea: insights from genomics and structural modeling. , 2008, Results and problems in cell differentiation.
[80] I. Belevich,et al. Molecular mechanism of proton translocation by cytochrome c oxidase. , 2008, Antioxidants & redox signaling.
[81] M. Brunori,et al. Cytochrome c oxidase, ligands and electrons. , 2005, Journal of inorganic biochemistry.
[82] R. Gennis. Coupled proton and electron transfer reactions in cytochrome oxidase. , 2004, Frontiers in bioscience : a journal and virtual library.
[83] Judith P Klinman,et al. Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics. , 2002, European journal of biochemistry.
[84] R. Gennis,et al. A mutation in subunit I of cytochrome oxidase from Rhodobacter sphaeroides results in an increase in steady-state activity but completely eliminates proton pumping. , 2002, Biochemistry.
[85] J. Ulstrup,et al. Proton and hydrogen atom tunnelling in hydrolytic and redox enzyme catalysis , 1999 .
[86] P. Brzezinski,et al. The Deuterium Isotope Effect as a Tool to Investigate Enzyme Catalysis: Proton‐Transfer Control Mechanisms in Cytochrome c Oxidase , 1999 .
[87] P. Rich,et al. Cytochrome c Oxidase , 1997 .
[88] P. Rich. Towards an understanding of the chemistry of oxygen reduction and proton translocation in the iron-copper respiratory oxidases , 1995 .
[89] R. Schowen,et al. [29] Solvent isotope effects on enzyme systems , 1982 .
[90] A. Warshel. Interpretation of resonance Raman spectra of biological molecules. , 1977, Annual review of biophysics and bioengineering.
[91] A. Rahman,et al. Computation of intensities of vibrational spectra of electronic bands in diatomic molecules. II , 1954 .