The concept of regulation for human body temperature

Abstract 1. 1.The regulated variable of human temperature regulation is certainly not a locally defined single temperature, it is probably not heat flow and not mean body temperature, but it seems to be a flexible and adaptable integrative temperature signal according to a distributed parameter control strategy. 2. 2.The regulator does not need any explicit reference, neither in the form of a neuronal signal nor in the form of the indifferent zone. 3. 3.Negative feedback is simply achieved by an odd number of negative input/output relations of the subsystems in the closed loop.