Gold nanoparticles sensing with diffusion reflection measurement as a new medical diagnostics application

The ability to quantitatively and noninvasively detect nanoparticles in vivo has important implications on their development as optical sensors for medical diagnostics. We suggest a new method for cancer detection based on diffusion reflection (DR) measurements of gold nanorods (GNR). In our talk, the ability to extract optical properties of phantoms and their GNR concentrations from DR measurements will demonstrate. We will report, for the first time, GNR detection through upper tissue-like phantom layers, as well as the detection of a tumor presented as highly concentrated GNR placed deep within a phantom.

[1]  Dror Fixler,et al.  Reflected light intensity profile of two-layer tissues: phantom experiments. , 2011, Journal of biomedical optics.

[2]  Guoqiang Yu,et al.  Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring. , 2012, Journal of biomedical optics.

[3]  B. Tromberg,et al.  Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy , 2000 .

[4]  Kort Travis,et al.  Controlled assembly of biodegradable plasmonic nanoclusters for near-infrared imaging and therapeutic applications. , 2010, ACS nano.

[5]  M Geso,et al.  Gold nanoparticles: a new X-ray contrast agent. , 2007, The British journal of radiology.

[6]  Menachem Motiei,et al.  A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods , 2012, International journal of nanomedicine.

[7]  Dror Fixler,et al.  On Phantom Experiments of the Photon Migration Model in Tissues , 2011 .

[8]  Campbell,et al.  Scattering and Imaging with Diffusing Temporal Field Correlations. , 1995, Physical review letters.

[9]  Mostafa A. El-Sayed,et al.  Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method , 2003 .

[10]  B. Tromberg,et al.  Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[11]  M. El-Sayed,et al.  Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. , 2006, Chemical Society reviews.

[12]  D. Weitz,et al.  Diffusing wave spectroscopy. , 1988, Physical review letters.

[13]  J. Ostrander,et al.  Monitoring of receptor dimerization using plasmonic coupling of gold nanoparticles. , 2011, ACS nano.

[14]  V. R. Kondepati,et al.  Recent applications of near-infrared spectroscopy in cancer diagnosis and therapy , 2008, Analytical and bioanalytical chemistry.

[15]  Wilhelm Stork,et al.  Noninvasive real-time laser Doppler flowmetry in perfusion regions and larger vessels , 1999, European Conference on Biomedical Optics.

[16]  B. Wilson,et al.  The propagation of optical radiation in tissue I. Models of radiation transport and their application , 1991, Lasers in Medical Science.

[17]  H. Dai,et al.  High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes , 2010, Nano research.

[18]  A H Hielscher,et al.  Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions. , 1997, Applied optics.

[19]  Hamootal Duadi,et al.  In‐vivo Tumor detection using diffusion reflection measurements of targeted gold nanorods – a quantitative study , 2012, Journal of biophotonics.

[20]  D. Boas,et al.  Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation , 1997 .

[21]  A. Villringer,et al.  Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[22]  Dror Fixler,et al.  Subcutaneous gold nanoroad detection with diffusion reflection measurement , 2013, Journal of biomedical optics.

[23]  E. Gratton,et al.  Noninvasive optical method of measuring tissue and arterial saturation: an application to absolute pulse oximetry of the brain. , 1999, Optics letters.

[24]  May D. Wang,et al.  In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags , 2008, Nature Biotechnology.

[25]  Li Gang,et al.  Determination of tissue optical properties from spatially resolved relative diffuse reflectance by PCA-NN , 2003, International Conference on Neural Networks and Signal Processing, 2003. Proceedings of the 2003.

[26]  Quing Zhu,et al.  Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoring. , 2007, Surgical oncology clinics of North America.

[27]  B. Pogue,et al.  Tutorial on diffuse light transport. , 2008, Journal of biomedical optics.

[28]  R Cubeddu,et al.  A solid tissue phantom for photon migration studies. , 1997, Physics in medicine and biology.

[29]  F. Jöbsis Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. , 1977, Science.

[30]  H. A. Ferwerda,et al.  Scattering and absorption of turbid materials determined from reflection measurements. 1: theory. , 1983, Applied optics.

[31]  Raoul Kopelman,et al.  Targeted gold nanoparticles enable molecular CT imaging of cancer. , 2008, Nano letters.

[32]  Qizhi Zhang,et al.  Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography , 2009, Nanotechnology.

[33]  Mostafa A. El-Sayed,et al.  Why Gold Nanoparticles Are More Precious than Pretty Gold: Noble Metal Surface Plasmon Resonance and Its Enhancement of the Radiative and Nonradiative Properties of Nanocrystals of Different Shapes , 2006 .

[34]  Menachem Motiei,et al.  Intercoupling surface plasmon resonance and diffusion reflection measurements for real‐time cancer detection , 2013, Journal of biophotonics.

[35]  P. Jain,et al.  Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. , 2006, The journal of physical chemistry. B.