Reversible morphology transitions of supramolecular polymer self-assemblies for switch-controlled drug release.

A novel method for switch-controlled drug release was developed through the reversible morphology transitions of supramolecular branched copolymer self-assemblies. The reversible transitions from vesicles to nanoparticles were successfully achieved by alternating UV and visible light irradiation to obtain morphology-controlled drug release in a switch mode.

[1]  Yanli Zhao,et al.  Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions. , 2015, Chemical reviews.

[2]  Gustavo Fernández,et al.  Strategies to create hierarchical self-assembled structures via cooperative non-covalent interactions. , 2015, Chemical Society reviews.

[3]  Xiaodong Fan,et al.  Ultrasound-driven secondary self-assembly of amphiphilic β-cyclodextrin dimers. , 2015, Chemistry.

[4]  C. S. Y. Tan,et al.  Hybrid Supramolecular and Colloidal Hydrogels that Bridge Multiple Length Scales , 2015, Angewandte Chemie.

[5]  Tingting Liu,et al.  Morphology transitions of supramolecular hyperbranched polymers induced by double supramolecular driving forces , 2015 .

[6]  Xiaodong Chen,et al.  Stimuli‐Responsive Supramolecular Interfaces for Controllable Bioelectrocatalysis , 2014 .

[7]  Feng Chen,et al.  pH and Amphiphilic Structure Direct Supramolecular Behavior in Biofunctional Assemblies , 2014, Journal of the American Chemical Society.

[8]  Xinyuan Zhu,et al.  Self-assembly of supramolecularly engineered polymers and their biomedical applications. , 2014, Chemical communications.

[9]  Yunqing Zhu,et al.  How does a tiny terminal alkynyl end group drive fully hydrophilic homopolymers to self-assemble into multicompartment vesicles and flower-like complex particles? , 2014 .

[10]  Xian‐Zheng Zhang,et al.  Switch on/off microcapsules for controllable photosensitive drug release in a ‘release-cease-recommence’ mode , 2014 .

[11]  O. Scherman,et al.  Supramolecular polymerization promoted and controlled through self-sorting. , 2014, Angewandte Chemie.

[12]  A. Meister,et al.  Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-oxazoline)s , 2014, ACS nano.

[13]  D. Qu,et al.  Multistate self-assembled micro-morphology transitions controlled by host-guest interactions. , 2014, Chemical communications.

[14]  I. Lednev,et al.  Is Supramolecular Filament Chirality the Underlying Cause of Major Morphology Differences in Amyloid Fibrils? , 2014, Journal of the American Chemical Society.

[15]  Xiaofan Ji,et al.  A Novel Diblock Copolymer with a Supramolecular Polymer Block and a Traditional Polymer Block: Preparation, Controllable Self‐Assembly in Water, and Application in Controlled Release , 2013, Advanced materials.

[16]  Yunqing Zhu,et al.  Antibacterial high-genus polymer vesicle as an "armed" drug carrier. , 2013, Journal of materials chemistry. B.

[17]  R. Vachet,et al.  Electrostatic control of peptide side-chain reactivity using amphiphilic homopolymer-based supramolecular assemblies. , 2013, Journal of the American Chemical Society.

[18]  E. Marques,et al.  Morphology, thermal behavior, and stability of self-assembled supramolecular tubules from lysine-based surfactants. , 2013, The journal of physical chemistry. B.

[19]  N. Giuseppone,et al.  Supramolecular self-assemblies as functional nanomaterials. , 2013, Nanoscale.

[20]  Jianzhong Du,et al.  Ultrasound and pH Dually Responsive Polymer Vesicles for Anticancer Drug Delivery , 2013, Scientific Reports.

[21]  Li Zhang,et al.  Solvent-polarity-tuned morphology and inversion of supramolecular chirality in a self-assembled pyridylpyrazole-linked glutamide derivative: nanofibers, nanotwists, nanotubes, and microtubes. , 2013, Chemistry.

[22]  Mian Hasnain Nawaz,et al.  Photocontrolled reversible supramolecular assemblies of a diblock azo-copolymer based on β-cyclodextrin–Azo host–guest inclusion complexation , 2013 .

[23]  O. Scherman,et al.  Supramolecular peptide amphiphile vesicles through host-guest complexation. , 2012, Angewandte Chemie.

[24]  S. Rowan,et al.  Supramolecular gels formed from multi-component low molecular weight species. , 2012, Chemical Society reviews.

[25]  Feihe Huang,et al.  Stimuli-responsive supramolecular polymeric materials. , 2012, Chemical Society reviews.

[26]  Yu Liu,et al.  Cholinesterase-responsive supramolecular vesicle. , 2012, Journal of the American Chemical Society.

[27]  Krishna Dan,et al.  Vesicular assembly and thermo-responsive vesicle-to-micelle transition from an amphiphilic random copolymer. , 2011, Chemical communications.

[28]  Y. Liu,et al.  Photo-reversible supramolecular hyperbranched polymer based on host–guest interactions , 2011 .

[29]  Renjith P. Johnson,et al.  Morphology-tunable architectures constructed by supramolecular assemblies of α-diimine compound: fabrication and application as multifunctional host systems , 2011 .

[30]  A. Nandi,et al.  Tuning of the morphology of a riboflavin-melamine equimolar supramolecular assembly by in situ silver nanoparticle formation. , 2011, Chemical communications.

[31]  Jinying Yuan,et al.  Light-controlled smart nanotubes based on the orthogonal assembly of two homopolymers. , 2011, Chemical communications.

[32]  V. Yam,et al.  Supramolecular self-assembly of amphiphilic anionic platinum(II) complexes: a correlation between spectroscopic and morphological properties. , 2011, Journal of the American Chemical Society.

[33]  R. Sougrat,et al.  From micelle supramolecular assemblies in selective solvents to isoporous membranes. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[34]  Guosong Chen,et al.  Cyclodextrin-based inclusion complexation bridging supramolecular chemistry and macromolecular self-assembly. , 2011, Chemical Society reviews.

[35]  Lixin Wu,et al.  Smart self-assemblies based on a surfactant-encapsulated photoresponsive polyoxometalate complex. , 2010, Angewandte Chemie.

[36]  Jian Ji,et al.  Photo-responsive supramolecular self-assembly and disassembly of an azobenzene-containing block copolymer , 2010 .

[37]  H. Möhwald,et al.  Recent progress in morphology control of supramolecular fullerene assemblies and its applications. , 2010, Chemical Society reviews.

[38]  Akira Harada,et al.  Photoswitchable supramolecular hydrogels formed by cyclodextrins and azobenzene polymers. , 2010, Angewandte Chemie.

[39]  T. Nakanishi Supramolecular soft and hard materials based on self-assembly algorithms of alkyl-conjugated fullerenes. , 2010, Chemical communications.

[40]  T. Fahmy,et al.  Controlling the morphology of electrospray-generated PLGA microparticles for drug delivery. , 2010, Journal of colloid and interface science.

[41]  Elena E. Dormidontova,et al.  Tunable supramolecular networks via cis-trans metal–ligand isomerization , 2010 .

[42]  Bhanu Nandan,et al.  Composition-Dependent Morphological Transitions and Pathways in Switching of Fine Structure in Thin Films of Block Copolymer Supramolecular Assemblies , 2010 .

[43]  M. Goto,et al.  Proteinase-mediated drastic morphological change of peptide-amphiphile to induce supramolecular hydrogelation. , 2010, Chemical communications.

[44]  Xi Zhang,et al.  Photocontrolled self-assembly and disassembly of block ionomer complex vesicles: a facile approach toward supramolecular polymer nanocontainers. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[45]  Xi Zhang,et al.  Tuning the Amphiphilicity of Building Blocks: Controlled Self‐Assembly and Disassembly for Functional Supramolecular Materials , 2009 .

[46]  J Fraser Stoddart,et al.  Azobenzene-based light-responsive hydrogel system. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[47]  A. Müller,et al.  Switching the morphologies of cylindrical polycation brushes by ionic and supramolecular inclusion complexes. , 2009, Journal of the American Chemical Society.

[48]  S. Rowan,et al.  Control of gel morphology and properties of a class of metallo- supramolecular polymers by good/poor solvent environments , 2009 .

[49]  Toshimi Shimizu,et al.  Supramolecular nanotube architectures based on amphiphilic molecules. , 2005, Chemical reviews.

[50]  C. Bazuin,et al.  Solvent-assisted formation of nanostrand networks from supramolecular diblock copolymer/surfactant complexes at the air/water interface. , 2005, Nano letters.

[51]  Huisheng Peng,et al.  pH-dependent self-assembly: micellization and micelle-hollow-sphere transition of cellulose-based copolymers. , 2003, Angewandte Chemie.

[52]  S. Yalkowsky,et al.  Combined effect of complexation and pH on solubilization. , 1998, Journal of pharmaceutical sciences.

[53]  Zhou,et al.  First Observation of the Molten Globule State of a Single Homopolymer Chain. , 1996, Physical review letters.

[54]  Mohammad Erfan,et al.  Changes in morphology of in situ forming PLGA implant prepared by different polymer molecular weight and its effect on release behavior. , 2009, Journal of pharmaceutical sciences.

[55]  M. Schmittel,et al.  Functional, Discrete, Nanoscale Supramolecular Assemblies , 2005 .