Contribution of the K88 antigen of Escherichia coli to enteropathogenicity; protection against disease by neutralizing the adhesive properties of K88 antigen.

The adhesive properties of K88 antigen and its contribution to the enteropathogenic character of K88-positive Escherichia coliare briefly discussed. Factors that may be involved in the protection of piglets from dams vaccinated with bacteria-free K88 antigen have been examined, and on the basis of in vitro tests, it is concluded that a significant protective effect is due to an antiadhesive factor in the colostrum of vaccinated sows. Am. J. Clin. Nutr. 27: 1441-1449, 1974. The recognition of microbial virulence deter- minants and their role in the pathogenesis of enteric disease may provide a more rational basis for studies of the protective response of the host. In addition, investigations of the biological activities of virulence determinants could lead to improved methods of protection that render the bacteria less able to colonize the host tissue. We have used this approach to disease control in an investigation of mortality caused by Escherichla coil in piglets, part of

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