Resilin-based Materials for Biomedical Applications.

Resilin, an insect structural protein, exhibits rubber-like elasticity characterized by low stiffness, high extensibility, efficient energy storage, and exceptional resilience and fatigue lifetime. The outstanding mechanical properties of natural resilin have motivated recent research in the engineering of resilin-like polypeptide-based biomaterials, with a wide range of applications including use as bio-rubbers, nanosprings, elements in biosensors, and tissue engineering scaffolds.

[1]  D. Kaplan,et al.  Expression, cross-linking and characterization of recombinant chitin binding resilin , 2009, Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC).

[2]  C. Elvin,et al.  Self-organization, interfacial interaction and photophysical properties of gold nanoparticle complexes derived from resilin-mimetic fluorescent protein rec1-resilin. , 2011, Biomaterials.

[3]  Jeffrey M. Caves,et al.  Deformation responses of a physically cross-linked high molecular weight elastin-like protein polymer. , 2008, Biomacromolecules.

[4]  A. Bausch,et al.  Towards constructing extracellular matrix-mimetic hydrogels: an elastic hydrogel constructed from tandem modular proteins containing tenascin FnIII domains. , 2013, Acta biomaterialia.

[5]  Bennet-Clark Tymbal mechanics and the control of song frequency in the cicada Cyclochila australasiae , 1997, The Journal of experimental biology.

[6]  Kristi L Kiick,et al.  Manipulation of hydrogel assembly and growth factor delivery via the use of peptide-polysaccharide interactions. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[7]  Hongbin Li,et al.  Polyprotein of GB1 is an ideal artificial elastomeric protein. , 2007, Nature materials.

[8]  S. O. Andersen,et al.  Tentative identification of a resilin gene in Drosophila melanogaster. , 2001, Insect biochemistry and molecular biology.

[9]  Misook Kim,et al.  A synthetic resilin is largely unstructured. , 2008, Biophysical journal.

[10]  H. Tao,et al.  Protein‐Protein Nanoimprinting of Silk Fibroin Films , 2013, Advanced materials.

[11]  D. Dudek,et al.  Designed biomaterials to mimic the mechanical properties of muscles , 2010, Nature.

[12]  Duilio Cascio,et al.  Structure of a 16-nm Cage Designed by Using Protein Oligomers , 2012, Science.

[13]  Kristi L Kiick,et al.  Elastomeric polypeptide-based biomaterials. , 2010, Journal of polymer science. Part A, Polymer chemistry.

[14]  A. Huxley,et al.  On the structure of resilin , 1965 .

[15]  Kenneth Bailey,et al.  Amino acid composition of a new rubber-like protein, resilin , 1961 .

[16]  Sarah C. Heilshorn,et al.  Independent tuning of multiple biomaterial properties using protein engineering , 2009 .

[17]  K. Matyjaszewski,et al.  Polymer science : a comprehensive reference , 2012 .

[18]  Paulo J. Fonseca,et al.  Asymmetry of tymbal action and structure in a cicada: a possible role in the production of complex songs , 1998, The Journal of experimental biology.

[19]  R. Lyons,et al.  High yield expression of recombinant pro-resilin: lactose-induced fermentation in E. coli and facile purification. , 2007, Protein expression and purification.

[20]  David A Tirrell,et al.  Comparative cell response to artificial extracellular matrix proteins containing the RGD and CS5 cell-binding domains. , 2004, Biomacromolecules.

[21]  Xinqiao Jia,et al.  Tunable mechanical stability and deformation response of a resilin-based elastomer. , 2011, Biomacromolecules.

[22]  Kevin M. Cherry,et al.  Characterization of resilin-based materials for tissue engineering applications. , 2012, Biomacromolecules.

[23]  Eileen Ingham,et al.  Production of self-assembling biomaterials for tissue engineering , 2009, Trends in biotechnology.

[24]  K. Kiick Peptide- and protein-mediated assembly of heparinized hydrogels. , 2008, Soft matter.

[25]  C. Elvin,et al.  Physical approaches for fabrication of organized nanostructure of resilin-mimetic elastic protein rec1-resilin. , 2009, Biomaterials.

[26]  Xinqiao Jia,et al.  Resilin-Like Polypeptide Hydrogels Engineered for Versatile Biological Functions. , 2013, Soft matter.

[27]  F. Sbrana,et al.  Multiscale characterization of a chimeric biomimetic polypeptide for stem cell culture , 2012, Bioinspiration & biomimetics.

[28]  T. Vuocolo,et al.  Synthesis and properties of crosslinked recombinant pro-resilin , 2005, Nature.

[29]  C. Elvin,et al.  A genetically engineered protein responsive to multiple stimuli. , 2011, Angewandte Chemie.

[30]  David A Tirrell,et al.  Protein engineering approaches to biomaterials design. , 2005, Current opinion in biotechnology.

[31]  T. Weis-Fogh A Rubber-Like Protein in Insect Cuticle , 1960 .

[32]  K. Kiick,et al.  Resilin-Based Hybrid Hydrogels for Cardiovascular Tissue Engineering. , 2013, Macromolecules.

[33]  Jiyuan Yang,et al.  Smart self-assembled hybrid hydrogel biomaterials. , 2012, Angewandte Chemie.

[34]  Ralph Müller,et al.  Repair of bone defects using synthetic mimetics of collagenous extracellular matrices , 2003, Nature Biotechnology.

[35]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[36]  Horst Kessler,et al.  RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. , 2003, Biomaterials.

[37]  Karl Fischer,et al.  Temperature triggered self-assembly of polypeptides into multivalent spherical micelles. , 2008, Journal of the American Chemical Society.

[38]  H. Blau,et al.  Protein‐Engineered Biomaterials to Generate Human Skeletal Muscle Mimics , 2012, Advanced healthcare materials.

[39]  A. Chilkoti,et al.  Biomedical and Biotechnological Applications of Elastin-Like Polypeptides , 2007 .

[40]  B. Olsen,et al.  Solid-state nanostructured materials from self-assembly of a globular protein-polymer diblock copolymer. , 2011, ACS nano.

[41]  Brigida Bochicchio,et al.  Molecular and Supramolecular Structural Studies on Significant Repetitive Sequences of Resilin , 2009, Chembiochem : a European journal of chemical biology.

[42]  Ji Seok Lee,et al.  Two-component protein-engineered physical hydrogels for cell encapsulation , 2009, Proceedings of the National Academy of Sciences.

[43]  David L Kaplan,et al.  Recombinant exon-encoded resilins for elastomeric biomaterials. , 2011, Biomaterials.

[44]  A. Chilkoti,et al.  Digital switching of local arginine density in a genetically encoded self-assembled polypeptide nanoparticle controls cellular uptake. , 2012, Nano letters.

[45]  T. Weis-Fogh,et al.  Biology and physics of locust flight. V. Strength and elasticity of locust cuticle , 1962, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[46]  G. Fields,et al.  Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides. , 1996, Biopolymers.

[47]  T. Weis-Fogh Thermodynamic properties of resilin, a rubber-like protein , 1961 .

[48]  J. Hubbell,et al.  Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: systematic modulation of a synthetic cell-responsive PEG-hydrogel. , 2008, Biomaterials.

[49]  E. Furst,et al.  Growth factor mediated assembly of cell receptor-responsive hydrogels. , 2007, Journal of the American Chemical Society.

[50]  R. Lyons,et al.  Purification of recombinant protein by cold‐coacervation of fusion constructs incorporating resilin‐inspired polypeptides , 2012, Biotechnology and bioengineering.

[51]  Jason A Burdick,et al.  Hydrophilic elastomeric biomaterials based on resilin-like polypeptides. , 2009, Soft matter.

[52]  R. Lyons,et al.  Comparisons of recombinant resilin-like proteins: repetitive domains are sufficient to confer resilin-like properties. , 2009, Biomacromolecules.

[53]  Massimo Vassalli,et al.  Design and production of a chimeric resilin-, elastin-, and collagen-like engineered polypeptide. , 2011, Biomacromolecules.

[54]  S. Heilshorn,et al.  Multifunctional Materials through Modular Protein Engineering , 2012, Advanced materials.

[55]  Dan W. Urry,et al.  Circular dichroism and absorption of the polytetrapeptide of elastin: A polymer model for the β-turn , 1974 .

[56]  Brigida Bochicchio,et al.  Investigating by CD the molecular mechanism of elasticity of elastomeric proteins. , 2008, Chirality.

[57]  S. M. Partridge,et al.  The chemistry of connective tissues. 3. Composition of the soluble proteins derived from elastin. , 1955, The Biochemical journal.

[58]  T. Weis-Fogh Molecular interpretation of the elasticity of resilin, a rubber-like protein , 1961 .

[59]  C. Elvin,et al.  A pH-responsive interface derived from resilin-mimetic protein Rec1-resilin. , 2010, Biomaterials.

[60]  K. Kiick Biosynthetic Methods for the Production of Advanced Protein‐Based Materials , 2007 .

[61]  H. Bennet-Clark THE FIRST DESCRIPTION OF RESILIN , 2007, Journal of Experimental Biology.