Mitochondrial diabetes is associated with insulin resistance in subcutaneous adipose tissue but not with increased liver fat content

[1]  H. Lamb,et al.  Liver Fat Content in Type 2 Diabetes: Relationship With Hepatic Perfusion and Substrate Metabolism , 2010, Diabetes.

[2]  S. Dimauro,et al.  A novel POLG gene mutation in 4 children with Alpers-like hepatocerebral syndromes. , 2010, Archives of neurology.

[3]  Ping-Chih Ho,et al.  A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160 , 2009, Cell metabolism.

[4]  H. Gin,et al.  The clinical variability of maternally inherited diabetes and deafness is associated with the degree of heteroplasmy in blood leukocytes. , 2009, The Journal of clinical endocrinology and metabolism.

[5]  P. Iozzo,et al.  m.3243A>G Mutation in Mitochondrial DNA Leads to Decreased Insulin Sensitivity in Skeletal Muscle and to Progressive β-Cell Dysfunction , 2009, Diabetes.

[6]  Leif Groop,et al.  Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes , 2009, Diabetes Care.

[7]  T. Lehtimäki,et al.  Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects , 2009, Annals of medicine.

[8]  M. Czech,et al.  Paradoxical Effect of Mitochondrial Respiratory Chain Impairment on Insulin Signaling and Glucose Transport in Adipose Cells* , 2008, Journal of Biological Chemistry.

[9]  P. Iozzo,et al.  Inverse association between liver fat content and hepatic glucose uptake in patients with type 2 diabetes mellitus. , 2008, Metabolism: clinical and experimental.

[10]  B. S. Mohammed,et al.  Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. , 2008, Gastroenterology.

[11]  Leena Peltonen,et al.  Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity , 2008, PLoS medicine.

[12]  A. Kotronen,et al.  Fatty Liver: A Novel Component of the Metabolic Syndrome , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[13]  P. Bénit,et al.  Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes , 2007, Cell.

[14]  P. Iozzo,et al.  Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs. , 2007, Gastroenterology.

[15]  M. Schwartz,et al.  Muscle phenotype and mutation load in 51 persons with the 3243A>G mitochondrial DNA mutation. , 2006, Archives of neurology.

[16]  H. Westerblad,et al.  Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance. , 2006, Biochemical and biophysical research communications.

[17]  Kohjiro Ueki,et al.  Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. , 2006, The Journal of clinical investigation.

[18]  P. Iozzo,et al.  18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  P. Scifo,et al.  Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes , 2005, Diabetologia.

[20]  K. Kotani,et al.  Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. , 2005, American journal of physiology. Endocrinology and metabolism.

[21]  R. Huupponen,et al.  Increased fat mass compensates for insulin resistance in abdominal obesity and type 2 diabetes: a positron-emitting tomography study. , 2005, Diabetes.

[22]  S. Grundy,et al.  Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. , 2005, American journal of physiology. Endocrinology and metabolism.

[23]  E. Ravussin,et al.  Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus , 2004, International Journal of Obesity.

[24]  G. Nijpels,et al.  Mitochondrial diabetes: molecular mechanisms and clinical presentation. , 2004, Diabetes.

[25]  M. Danna,et al.  Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes. , 2003, American journal of physiology. Endocrinology and metabolism.

[26]  P. Iozzo,et al.  Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes. , 2003, Diabetes care.

[27]  P. Iozzo,et al.  Insulin-mediated hepatic glucose uptake is impaired in type 2 diabetes: evidence for a relationship with glycemic control. , 2003, The Journal of clinical endocrinology and metabolism.

[28]  Juhani Knuuti,et al.  Insulin stimulates liver glucose uptake in humans: an 18F-FDG PET Study. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[29]  John Wilding,et al.  Obesity and Diabetes , 2010, Experimental and Clinical Endocrinology & Diabetes.

[30]  T. Funahashi,et al.  Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. , 2003, The Journal of clinical endocrinology and metabolism.

[31]  R. Huupponen,et al.  Human adipose tissue glucose uptake determined using [18F]-fluoro-deoxy-glucose ([18F]FDG) and PET in combination with microdialysis , 2001, Diabetologia.

[32]  P. Reiss,et al.  Lipodystrophy in HIV-1-positive patients is associated with insulin resistance in multiple metabolic pathways , 2001, AIDS.

[33]  P. Arner,et al.  Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects. , 2000, Diabetes.

[34]  K. Majamaa,et al.  Epidemiology of A3243G, the mutation for mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes: prevalence of the mutation in an adult population. , 1998, American journal of human genetics.

[35]  R M Peshock,et al.  Prediction of total subcutaneous abdominal, intraperitoneal, and retroperitoneal adipose tissue masses in men by a single axial magnetic resonance imaging slice. , 1997, The American journal of clinical nutrition.

[36]  S. Kalhan,et al.  Hepatic insulin action in adolescents with insulin-dependent diabetes mellitus: relationship with long-term glycemic control. , 1993, Metabolism: clinical and experimental.

[37]  R. Sokol,et al.  Liver involvement in Alpers disease. , 1991, The Journal of pediatrics.