Crystallographic Insight Into the Mechanism of Drug-Induced Topoisomerase I DNA Damage
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A. Burgin | L. Stewart | B. Staker | M. Feese
[1] Lance Stewart,et al. The mechanism of topoisomerase I poisoning by a camptothecin analog , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[2] J. Verweij,et al. Modulation of camptothecin analogs in the treatment of cancer: a review , 2001, Anti-cancer drugs.
[3] J. Champoux. Structure‐Based Analysis of the Effects of Camptothecin on the Activities of Human Topoisomerase I , 2000, Annals of the New York Academy of Sciences.
[4] M. Manfait,et al. Kinetics of in Vitro Hydrolysis of Homocamptothecins As Measured by Fluorescence , 2000, Annals of the New York Academy of Sciences.
[5] S. Shuman,et al. Catalytic mechanism of DNA topoisomerase IB. , 2000, Molecular cell.
[6] Y. Pommier,et al. Substitutions of Asn-726 in the Active Site of Yeast DNA Topoisomerase I Define Novel Mechanisms of Stabilizing the Covalent Enzyme-DNA Intermediate* , 2000, The Journal of Biological Chemistry.
[7] M. Bjornsti,et al. Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity. , 1999, Molecular pharmacology.
[8] J. Champoux,et al. A Functional Linker in Human Topoisomerase I Is Required for Maximum Sensitivity to Camptothecin in a DNA Relaxation Assay* , 1999, The Journal of Biological Chemistry.
[9] R. Kiss,et al. Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties. , 1999, Cancer research.
[10] S. Hecht,et al. Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex. , 1999, Biochemistry.
[11] Y. Pommier,et al. Modulation in kinetics of lactone ring hydrolysis of camptothecins upon interaction with topoisomerase I cleavage sites on DNA. , 1998, Biochemistry.
[12] J. Champoux,et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. , 1998, Science.
[13] W G Hol,et al. A model for the mechanism of human topoisomerase I. , 1998, Science.
[14] L. Liu,et al. Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis. , 1997, Biochemical pharmacology.
[15] G. Ireton,et al. Biochemical and Biophysical Analyses of Recombinant Forms of Human Topoisomerase I (*) , 1996, The Journal of Biological Chemistry.
[16] H. Nash,et al. A novel suicide substrate for DNA topoisomerases and site-specific recombinases. , 1995, Nucleic acids research.
[17] A. Mildvan,et al. Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions. , 1994, Biochemistry.
[18] Eric Patterson,et al. Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites , 1991, Nucleic Acids Res..
[19] L. Liu,et al. DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. , 1989, Science.
[20] J. Wang,et al. Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin. , 1989, Cancer research.
[21] L. Liu,et al. DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. , 1989, Cancer research.
[22] R. Hertzberg,et al. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex. , 1989, Biochemistry.
[23] K. Kohn,et al. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. , 1989, Cancer research.
[24] R. Hertzberg,et al. Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. , 1989, Journal of medicinal chemistry.
[25] J. Wang,et al. DNA topoisomerase-targeting antitumor drugs can be studied in yeast. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[26] R. Hertzberg,et al. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. , 1985, The Journal of biological chemistry.
[27] Wolfram Saenger,et al. Principles of Nucleic Acid Structure , 1983 .
[28] A. McPhail,et al. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2 , 1966 .
[29] J. Champoux. DNA topoisomerases: structure, function, and mechanism. , 2001, Annual review of biochemistry.
[30] M. Bjornsti,et al. Drug-induced stabilization of covalent DNA topoisomerase I-DNA intermediates. DNA cleavage assays. , 2001, Methods in molecular biology.
[31] L. Liu,et al. Tumor cell death induced by topoisomerase-targeting drugs. , 2001, Annual review of pharmacology and toxicology.
[32] L. Shen. DNA-unwinding test using eukaryotic DNA topoisomerase I. , 2001, Methods in molecular biology.
[33] Y. Pommier,et al. Topoisomerase I-mediated DNA damage. , 2001, Advances in cancer research.
[34] L. Liu,et al. DNA topoisomerases: essential enzymes and lethal targets. , 1994, Annual review of pharmacology and toxicology.