Activated Carbon / Dibutyrylchitin (DBC) as Fibrous Antibacterial Noncytotoxic Wound Dressing Material

In this study, a noncytotoxic fibrous dressing material was developed using an activated carbon nonwoven, directly overlaid with dibutyrylchitin fibres by electrospinning. This dress ing material is designed for wounds that are hard to heal. Its sorption capacity is imparted by highly adsorptive carbon fibres; when measured for distilled water, it is higher than that of commercially available silver-containing carbon dressing, and amounts to 6.63 g/g. As shown by tests, dibutyrylchitin fibres containing a bioactive substance ensure antimicrobial action showing none of the cytotoxic effects that occur in silver-containing dressings. The tests performed for this dressing material confirm that it shows no skin and eye irritating actions, no acute intra-gastric toxicity and no effect on the values of immunoglobulin E and fibrinogen concentration, which indicates that the material produces no allergic reaction.

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