Characterization and detection of experimental rat gliomas using magnetic resonance imaging

Two different experimental rat brain tumours (F98 glioma and 9L glioma) were characterized using T1 and T2, apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR). Even though both tumours appeared homogenous at the early stage of growth, significant differences were measured for all parametric images between tumours and normal brain tissue. Irrespective of the sequence used, tumour lesion/normal parenchyma contrast for the non-infiltrative 9L was twice that of the infiltrative F98 glioma. The use of spin preparation via an inversion pulse in a fast spin echo sequence increases contrast by a factor of 20–30.

[1]  R. Steen,et al.  Precise and accurate measurement of proton T1 in human brain in vivo: Validation and preliminary clinical application , 1994, Journal of magnetic resonance imaging : JMRI.

[2]  T L Chenevert,et al.  Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[3]  J. E. Tanner,et al.  Spin diffusion measurements : spin echoes in the presence of a time-dependent field gradient , 1965 .

[4]  E. Perkins,et al.  Sequential Imaging and Volumetric Analysis of an Intracerebral C6 Glioma by Means of a Clinical MRI System , 1999, Journal of Neuro-Oncology.

[5]  Risto A Kauppinen,et al.  Monitoring cytotoxic tumour treatment response by diffusion magnetic resonance imaging and proton spectroscopy , 2002, NMR in biomedicine.

[6]  K. Hossmann,et al.  In vivo relaxometry of three brain tumors in the rat: Effect of Mn‐TPPS, a tumor‐selective contrast agent , 1993, Journal of magnetic resonance imaging : JMRI.

[7]  R. Damadian.  Tumor Detection by Nuclear Magnetic Resonance , 1971, Science.

[8]  Franklyn A. Howe,et al.  Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted 1H-NMR spectroscopy in vivo , 1999 .

[9]  M Hoehn-Berlage,et al.  Quantitative diffusion MR imaging of cerebral tumor and edema. , 1994, Acta neurochirurgica. Supplementum.

[10]  M Hoehn-Berlage,et al.  High resolution quantitative relaxation and diffusion mri of three different experimental brain tumors in rat , 1995, Magnetic resonance in medicine.

[11]  F. Franconi,et al.  High‐field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour , 2000, NMR in biomedicine.

[12]  M. Fukui,et al.  Apparent diffusion coefficient (ADC) and magnetization transfer contrast (MTC) mapping of experimental brain tumor. , 1997, Acta neurochirurgica. Supplement.

[13]  J. Pipe,et al.  Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo. , 1996, British Journal of Cancer.

[14]  S. Rajan,et al.  MRI characterization of 9L-glioma in rat brain at 4.7 Tesla. , 1990, Magnetic resonance imaging.

[15]  P. Parizel,et al.  Gadolinium‐DOTA Enhanced MR Imaging of Intracranial Lesions , 1989, Journal of computer assisted tomography.

[16]  Jan Wolber,et al.  Diffusion MRI for prediction of response of rectal cancer to chemoradiation , 2002, The Lancet.

[17]  F. Franconi,et al.  Therapeutic efficacy of 5‐fluorouracil‐loaded microspheres on rat glioma: a magnetic resonance imaging study , 2001, NMR in biomedicine.

[18]  B Quesson,et al.  Magnetization transfer fast imaging of implanted glioma in the rat brain at 4.7 T: Interpretation using a binary spin‐bath model , 1997, Journal of magnetic resonance imaging : JMRI.