The molecular basis of blood coagulation

Humans require a robust hemostatic response to prevent exsanguination following injury. The host defense to tissue damage is tripartite and well orchestrated, with critical contributions by cooperating platelets, endothelial cells, and the circulating coagulation proteins. The blood coagulation cascade is an intricately complex web of positive and negative feedback loops finely tuned to ensure hemostasis without spontaneous hemorrhage or thrombosis. Here we focus on the molecular basis of blood coagulation with particular attention to the biochemistry and regulation of this pathway as it relates to humans in health and disease.

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