Hyperprolactinemia in systemic lupus erythematosus: association with disease activity.

This study was designed to determine the prevalence and clinical significance of hyperprolactinemia in systemic lupus erythematosus (SLE) and other rheumatic diseases. Basal levels of prolactin were determined in 130 nonselected sera from patients with rheumatic diseases including 45 with SLE, 31 with rheumatoid arthritis, 23 with osteoarthritis, 18 with fibromyalgia, and 13 with polymyalgia rheumatica. Serum samples of 28 healthy subjects were used as normal controls. Serum prolactin was measured by radioimmunoassay. ANA, anti-DNA, RNP, Sm, Ro, La, and anticardiolipin antibodies were determined by standard techniques. Elevated serum levels of prolactin (PRL greater than 20 ng/ml) were found in a subset of SLE patients. In addition, a direct correlation with clinical disease and serological (ANA) activity was also found. These findings suggest a potential role for this immunoregulatory hormone in SLE pathogenesis.

[1]  I. Chikanza,et al.  Hypothalamic-pituitary mediated modulation of immune function: prolactin as a neuroimmune peptide. , 1991, British journal of rheumatology.

[2]  L. Espinoza,et al.  Anticardiolipin antibodies in polymyalgia rheumatica-Giant cell arteritis: Association with severe vascular complications☆ , 1991 .

[3]  C. Lavalle,et al.  Prolactin, immunoregulation, and autoimmune diseases. , 1991, Seminars in arthritis and rheumatism.

[4]  C. Lavalle,et al.  Prolactin and gonadal hormones during pregnancy in systemic lupus erythematosus. , 1991, The Journal of rheumatology.

[5]  V. Nassonova,et al.  Prolactin levels in men with SLE and RA. , 1990, The Journal of rheumatology.

[6]  J. Copeland,et al.  Analysis of risk factors for acute allograft rejection after heart transplantation. , 1990, The Journal of heart transplantation.

[7]  F. Salaffi,et al.  Neuroendocrinologic findings in primary fibromyalgia (soft tissue chronic pain syndrome) and in other chronic rheumatic conditions (rheumatoid arthritis, low back pain) , 1990, The Journal of rheumatology.

[8]  P. Limburg,et al.  Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. A long-term, prospective study. , 1990, Arthritis and rheumatism.

[9]  T. Saruta,et al.  Effect of Captopril on Plasma Prolactin in Patients with Essential Hypertension , 1990, Angiology.

[10]  D. Larson,et al.  Freund's complete adjuvant induces ornithine decarboxylase activity in the central nervous system of male rats and triggers the release of pituitary hormones , 1990, Journal of Neuroimmunology.

[11]  A. Mastro,et al.  Prolactin induction of interleukin-2 receptors on rat splenic lymphocytes. , 1990, Endocrinology.

[12]  B. Gellersen,et al.  Regulation of prolactin secretion in the human B-lymphoblastoid cell line IM-9-P3 by dexamethasone but not other regulators of pituitary prolactin secretion. , 1989, Endocrinology.

[13]  D. Russell.  New aspects of prolactin and immunity: a lymphocyte-derived prolactin-like product and nuclear protein kinase C activation. , 1989, Trends in pharmacological sciences.

[14]  J. Holaday,et al.  Rapid release of multiple hormones from rat pituitaries perifused with recombinant interleukin-1. , 1989, Life sciences.

[15]  B. Gellersen,et al.  A human B-lymphoblastoid cell line produces prolactin. , 1988, Endocrinology.

[16]  R. Nussenblatt,et al.  Therapy for human autoimmune uveitis with low-dose cyclosporine plus bromocriptine. , 1988, Transplantation proceedings.

[17]  Steĭnberg Ad,et al.  Pathogenesis of systemic lupus erythematosus. , 1988 .

[18]  M. Liang,et al.  The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. , 1988, Arthritis and rheumatism.

[19]  J. Holaday,et al.  Suppression of macrophage activation and T-lymphocyte function in hypoprolactinemic mice. , 1988, Science.

[20]  A. Goldstein,et al.  Stimulation of in vivo antibody production and concanavalin-A-induced mouse spleen cell mitogenesis by prolactin. , 1987, Immunopharmacology.

[21]  C. Zukoski,et al.  Concanavalin A-stimulated murine splenocytes produce a factor with prolactin-like bioactivity and immunoreactivity. , 1987, Biochemical and biophysical research communications.

[22]  R. Paniagua,et al.  Correlation study between prolactin and androgens in male patients with systemic lupus erythematosus. , 1987, The Journal of rheumatology.

[23]  R. Moskowitz,et al.  Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. , 1986, Arthritis and rheumatism.

[24]  D. Alarcón-Segovia,et al.  T-cell dysregulation in patients with hyperprolactinemia: effect of bromocriptine treatment. , 1986, Clinical immunology and immunopathology.

[25]  G. Bynke,et al.  Endogenous iridocyclitis relieved during treatment with bromocriptine. , 1985, American journal of ophthalmology.

[26]  T. Moore,et al.  Use of the HEp-2 cell substrate in the detection of antinuclear antibodies in juvenile rheumatoid arthritis. , 1984, Arthritis and rheumatism.

[27]  D. Alarcón-Segovia.  The pathogenesis of immune dysregulation in systemic lupus erythematosus. A troika. , 1984, The Journal of rheumatology.

[28]  F. Wolfe,et al.  Psychological status in primary fibrositis and fibrositis associated with rheumatoid arthritis. , 1984, The Journal of rheumatology.

[29]  A. Walker,et al.  Chloroquine affects prolactin secretion and Golgi morphology in the mammotroph. , 1984, Endocrinology.

[30]  S. Asa,et al.  Immunomodulation by bromocriptine. , 1983, Immunopharmacology.

[31]  Chang Rj.  Hyperprolactinemia and menstrual dysfunction. , 1983 .

[32]  M. Mucci,et al.  Thyroid autoimmunity in hyperprolactinaemic disorders. , 1983, Acta endocrinologica.

[33]  P. Limburg,et al.  B cell activity in systemic lupus erythematosus: depressed in vivo humoral immune response to a primary antigen (haemocyanin) and increased in vitro spontaneous immunoglobulin synthesis. , 1983, Clinical and experimental immunology.

[34]  H. R. Smith,et al.  Autoimmunity--a perspective. , 1983, Annual review of immunology.

[35]  J F Fries,et al.  The 1982 revised criteria for the classification of systemic lupus erythematosus. , 1982, Arthritis and rheumatism.

[36]  J. Kremer,et al.  Non-organic non-psychotic psychopathology (NONPP) in patients with systemic lupus erythematosus. , 1981, Seminars in arthritis and rheumatism.

[37]  M. Yunus,et al.  Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls. , 1981, Seminars in arthritis and rheumatism.

[38]  P. Wood,et al.  An evaluation of criteria for polymyalgia rheumatica. , 1979, Annals of the rheumatic diseases.

[39]  S. Yen,et al.  Circulating prolactin levels during the menstrual cycle: episodic release and diurnal variation. , 1973, American journal of obstetrics and gynecology.

[40]  P. Hwang,et al.  A radioimmunoassay for human prolactin. , 1971, Proceedings of the National Academy of Sciences of the United States of America.