OXIDATIVE PHOSPHORYLATION IN MUSCLE MITOCHONDRIA AND ITS POSSIBLE REGULATION

As my work has been done on liver mitochondria, rather than on heart muscle, it becomes incumbent upon me to compare the work on liver mitochondria with that reported on heart mitochondria, also called sarcosomes. Oxidative phosphorylation per se, will not be covered as, a t present, the subject is too abstruse and controversial, and the mechanisms are still sought. I shall emphasize the regulation of oxidation through the coupled oxidative phosphorylation system, a process well known in liver mitochondria and somewhat less well known in heart muscle mitochondria, and consider how this regulation might be reflected in the work of the heart. First I shall discuss briefly the known rudiments of phosphorylation as coupled to substrate oxidation and to electron transport. The sequence of reactions in the respiratory chain, as given below, is known chiefly through the work of Chance and Williams,' while the positions in this chain where ATP is formed are known primarily through the experiments of Lehningerm2

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