90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy

This feasibility study demonstrates 90Y quantitative bremsstrahlung imaging of patients undergoing high-dose myeloablative 90Y-ibritumomab treatment. Methods: The study includes pretherapy 111In SPECT/CT and planar whole-body (WB) imaging at 7 d and therapy 90Y SPECT/CT at 6 d and 90Y WB imaging at 1 d. Time–activity curves and organ-absorbed doses derived from 90Y SPECT images were compared with pretherapy 111In estimates. Organ activities derived from 90Y WB images at the first day were compared with corresponding pretherapy estimates. Results: Pretherapy 111In images from 3 patients were similar to the 90Y images. Differences between absorbed-dose estimates from pretherapy 111In and 90Y therapy were within 25%, except for the lungs. Corresponding activity differences derived from WB images were within 25%. Differences were ascribed to incomplete compensation methods and real differences in pharmacokinetics between pretherapy and therapy. Conclusion: Quantitative bremsstrahlung imaging to estimate organ activities and absorbed doses is feasible.

[1]  M Ljungberg,et al.  Evaluation of quantitative 90Y SPECT based on experimental phantom studies , 2008, Physics in medicine and biology.

[2]  Eric C Frey,et al.  A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT , 2005, Physics in medicine and biology.

[3]  K Erlandsson,et al.  Registration of emission and transmission whole-body scintillation-camera images. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  Michael Ljungberg,et al.  A new method to obtain transmission images for planar whole-body activity quantification. , 2005, Cancer biotherapy & radiopharmaceuticals.

[5]  Kenneth F. Koral,et al.  Volume reduction versus radiation dose for tumors in previously untreated lymphoma patients who received iodine‐131 tositumomab therapy , 2002, Cancer.

[6]  M. Ljungberg,et al.  A Monte Carlo program for the simulation of scintillation camera characteristics. , 1989, Computer methods and programs in biomedicine.

[7]  S. A. Bush,et al.  Follow-up of relapsed B-cell lymphoma patients treated with iodine-131-labeled anti-CD20 antibody and autologous stem-cell rescue. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  M Ljungberg,et al.  Registration of serial SPECT/CT images for three-dimensional dosimetry in radionuclide therapy , 2009, Physics in medicine and biology.

[9]  B. Tsui,et al.  A new method for modeling the spatially-variant, object-dependent scatter response function in SPECT , 1996, 1996 IEEE Nuclear Science Symposium. Conference Record.

[10]  Michael Ljungberg,et al.  An activity quantification method based on registration of CT and whole-body scintillation camera images, with application to 131I. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  R. J. Ott,et al.  IEEE Nuclear Science Symposium , 2005 .

[12]  T. Illidge,et al.  Antibody-induced intracellular signaling works in combination with radiation to eradicate lymphoma in radioimmunotherapy. , 2004, Blood.

[13]  P Segars,et al.  Evaluation of quantitative planar 90Y bremsstrahlung whole-body imaging , 2009, Physics in medicine and biology.

[14]  Michael Ljungberg,et al.  The LundADose method for planar image activity quantification and absorbed-dose assessment in radionuclide therapy. , 2005, Cancer biotherapy & radiopharmaceuticals.

[15]  Paul A. Viola,et al.  Multi-modal volume registration by maximization of mutual information , 1996, Medical Image Anal..

[16]  Guy Marchal,et al.  Multimodality image registration by maximization of mutual information , 1997, IEEE Transactions on Medical Imaging.