T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells
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A. Sher | W. Leonard | P. Monk | A. Cope | M. Arno | T. Woodruff | J. Köhl | R. Spolski | A. Klos | M. Cooper | L. O’Neill | A. Robertson | Rosanne Spolski | H. Lachmann | Rebecca C. Coll | Zu-Xi Yu | K. Mayer-Barber | B. Afzali | C. Kemper | E. West | P. Dutow | Neill | G. Arbore | C. Rheinheimer | O. LukeA.
[1] B. Ryffel,et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation , 2015, Nature Immunology.
[2] M. Kolev,et al. Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses , 2015, Immunity.
[3] C. Dinarello,et al. Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance , 2015, Proceedings of the National Academy of Sciences.
[4] K. Schroder,et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases , 2015, Nature Medicine.
[5] J. Köhl,et al. Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse , 2015, The Journal of Immunology.
[6] M. Kolev,et al. Complement — tapping into new sites and effector systems , 2014, Nature Reviews Immunology.
[7] K. Reymann,et al. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy , 2014, Kidney international.
[8] A. Sher,et al. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk , 2014, Nature.
[9] Markus F. Neurath,et al. Cytokines in inflammatory bowel disease , 2014, Nature Reviews Immunology.
[10] John D Lambris,et al. Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release , 2014, The Journal of Immunology.
[11] Hongyu Zhao,et al. Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. , 2014, Immunity.
[12] Xin Geng,et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection , 2013, Nature.
[13] T. Reinheckel,et al. Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation , 2013, Immunity.
[14] P. Dasgupta,et al. CD46: the 'multitasker' of complement proteins. , 2013, The international journal of biochemistry & cell biology.
[15] D. Fairlie,et al. C5a, but not C5a‐des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2 , 2013, Immunology and cell biology.
[16] W. Leonard,et al. Interleukin-21 Is a Critical Cytokine for the Generation of Virus-Specific Long-Lived Plasma Cells , 2013, Journal of Virology.
[17] X. Chen,et al. IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells , 2013, The Journal of experimental medicine.
[18] T. Woodruff,et al. C5L2: a controversial receptor of complement anaphylatoxin, C5a , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[19] J. Licht,et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. , 2013, Immunity.
[20] B. Ksander,et al. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. , 2013, Investigative ophthalmology & visual science.
[21] M. Heneka,et al. NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice , 2012, Nature.
[22] G. Kolios,et al. Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis , 2012, Mucosal Immunology.
[23] C. Floudas,et al. De novo protein design of agonists and antagonists of C5a receptors , 2012 .
[24] Graham M Lord,et al. The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells , 2012, Immunity.
[25] H. Lehr,et al. Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors , 2012, Digestive Diseases.
[26] L. O’Neill,et al. Biochemical regulation of the inflammasome , 2012, Critical reviews in biochemistry and molecular biology.
[27] Burkhard Becher,et al. IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells , 2012, The Journal of experimental medicine.
[28] J. V. Sarma,et al. New developments in C5a receptor signaling. , 2012, Cell health and cytoskeleton.
[29] S. Bonardelli,et al. Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up , 2012, International journal of applied & basic medical research.
[30] T. Miwa,et al. C5aR Expression in a Novel GFP Reporter Gene Knockin Mouse: Implications for the Mechanism of Action of C5aR Signaling in T Cell Immunity , 2012, The Journal of Immunology.
[31] D. Jarrossay,et al. Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β , 2012, Nature.
[32] E. Marcotte,et al. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses , 2012, Nature Reviews Genetics.
[33] N. Scarmeas,et al. The good, bad, and ugly? , 2012, Neurology.
[34] P. Menu,et al. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly , 2011, Clinical and experimental immunology.
[35] M. McDermott,et al. Inflammasomes and autoimmunity. , 2011, Trends in molecular medicine.
[36] R. Guimarães,et al. Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil , 2010, Autoimmunity.
[37] Graham M Lord,et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells , 2010, Nature Immunology.
[38] John D Lambris,et al. Complement: a key system for immune surveillance and homeostasis , 2010, Nature Immunology.
[39] Brigitta Stockinger,et al. Effector T cell plasticity: flexibility in the face of changing circumstances , 2010, Nature Immunology.
[40] Kate Schroder,et al. The NLRP3 Inflammasome: A Sensor for Metabolic Danger? , 2010, Science.
[41] C. Mackay,et al. The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction* , 2009, The Journal of Biological Chemistry.
[42] K. Mills,et al. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. , 2009, Immunity.
[43] Helen J. Lachmann,et al. In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes , 2009, The Journal of experimental medicine.
[44] W. Paul,et al. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation , 2009, Proceedings of the National Academy of Sciences.
[45] P. Monk,et al. The human complement fragment receptor, C5L2, is a recycling decoy receptor , 2009, Molecular immunology.
[46] D. Gerlier,et al. Human C3 Deficiency Associated with Impairments in Dendritic Cell Differentiation, Memory B Cells, and Regulatory T Cells1 , 2008, The Journal of Immunology.
[47] C. Gabay,et al. IL‐1, IL‐18, and IL‐33 families of cytokines , 2008, Immunological reviews.
[48] G. Dubyak,et al. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. , 2008, Immunity.
[49] P. Söderkvist,et al. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). , 2007, Rheumatology.
[50] K. Tracey,et al. IL-1α and IL-1β Are Endogenous Mediators Linking Cell Injury to the Adaptive Alloimmune Response1 , 2007, The Journal of Immunology.
[51] G. Meiffren,et al. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. , 2006, The Journal of clinical investigation.
[52] K. Mills,et al. A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis , 2006, The Journal of experimental medicine.
[53] Pixu Liu,et al. An Anti-inflammatory Function for the Complement Anaphylatoxin C5a-binding Protein, C5L2* , 2005, Journal of Biological Chemistry.
[54] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[55] F. Martinon,et al. NLRs join TLRs as innate sensors of pathogens. , 2005, Trends in immunology.
[56] P. Monk,et al. C5a Mutants Are Potent Antagonists of the C5a Receptor (CD88) and of C5L2 , 2004, Journal of Biological Chemistry.
[57] P. Monk,et al. The C terminus of the human C5a receptor (CD88) is required for normal ligand‐dependent receptor internalization , 1997, European journal of immunology.
[58] C. Dinarello,et al. Biologic basis for interleukin-1 in disease. , 1996, Blood.
[59] H. Okamura,et al. Cloning of a new cytokine that induces IFN-γ production by T cells , 1995, Nature.
[60] P. Handford,et al. The CD 46-Jagged 1 interaction is critical for human TH 1 immunity , 2012 .
[61] J. V. Sarma,et al. New developments in C 5 a receptor signaling , 2012 .
[62] Scott W. Cousins,et al. Implications for Age-Related Macular Degeneration , 2010 .
[63] K. Tracey,et al. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. , 2007, Journal of immunology.
[64] G. Meiffren,et al. Alterations in CD 46-mediated Tr 1 regulatory T cells in patients with multiple sclerosis , 2006 .
[65] P. Monk,et al. Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.