Differential tissue specific, temporal and spatial expression patterns of the Aggrecan gene is modulated by independent enhancer elements

[1]  Xingkai Zhang,et al.  Hypoxia-inducible factor-lα mediates aggrecan and collagen Π expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration. , 2017, Biochemical and biophysical research communications.

[2]  E. Furlong,et al.  Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements , 2017, Genes & development.

[3]  Jonathan M. Cairns,et al.  Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters , 2016, Cell.

[4]  Siyu Zhu,et al.  Systematic Reconstruction of Molecular Cascades Regulating GP Development Using Single-Cell RNA-Seq. , 2016, Cell reports.

[5]  L. Zon,et al.  Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. , 2016, Developmental cell.

[6]  Steven J. M. Jones,et al.  SOX9 modulates the expression of key transcription factors required for heart valve development , 2015, Development.

[7]  A. Jolma,et al.  DNA-dependent formation of transcription factor pairs alters their binding specificity , 2015, Nature.

[8]  R. O’Keefe,et al.  Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9 , 2015, Bone Research.

[9]  A. McMahon,et al.  Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. , 2015, Cell reports.

[10]  V. Lefebvre,et al.  The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis , 2015, Nucleic acids research.

[11]  M. Pellegrini,et al.  Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. , 2014, Developmental cell.

[12]  Y. Izumi,et al.  A candidate enhancer element responsible for high-level expression of the aggrecan gene in chondrocytes. , 2014, Journal of biochemistry.

[13]  Stephen C. J. Parker,et al.  Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants , 2013, Proceedings of the National Academy of Sciences.

[14]  R. O’Keefe,et al.  RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. , 2013, Arthritis and rheumatism.

[15]  Ke Liu,et al.  Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development , 2013, Proceedings of the National Academy of Sciences.

[16]  Jianning Tao,et al.  Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9 , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  R. Atit,et al.  Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification , 2012, Development.

[18]  S. Fisher,et al.  Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage. , 2012, Matrix biology : journal of the International Society for Matrix Biology.

[19]  Lee E. Edsall,et al.  A map of the cis-regulatory sequences in the mouse genome , 2012, Nature.

[20]  T. Honjo,et al.  Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development , 2012, Development.

[21]  V. Lefebvre,et al.  Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. , 2012, Developmental cell.

[22]  Scott Barolo,et al.  Shadow enhancers: Frequently asked questions about distributed cis‐regulatory information and enhancer redundancy , 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

[23]  R. Schwanbeck,et al.  Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation , 2011, Cell Death and Differentiation.

[24]  G. K. Davis,et al.  Phenotypic robustness conferred by apparently redundant transcriptional enhancers , 2010, Nature.

[25]  B. de Crombrugghe,et al.  The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template , 2010, Nucleic acids research.

[26]  T. Honjo,et al.  RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development , 2010, Development.

[27]  M. Groudine,et al.  Enhancers: the abundance and function of regulatory sequences beyond promoters. , 2010, Developmental biology.

[28]  K. Yutzey,et al.  Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development , 2009, Proceedings of the National Academy of Sciences.

[29]  V. Lefebvre,et al.  L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer , 2008, Molecular and Cellular Biology.

[30]  R. Lovell-Badge,et al.  Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer , 2008, Nature.

[31]  C. W. Ragsdale,et al.  Aggrecan is expressed by embryonic brain glia and regulates astrocyte development. , 2008, Developmental biology.

[32]  B. Bernard,et al.  Proteoglycan expression patterns in human hair follicle , 2007, The British journal of dermatology.

[33]  C. Little,et al.  Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. , 2007, The Journal of clinical investigation.

[34]  Brendan H. Lee,et al.  Dominance of SOX9 function over RUNX2 during skeletogenesis , 2006, Proceedings of the National Academy of Sciences.

[35]  Alan M. Moses,et al.  In vivo enhancer analysis of human conserved non-coding sequences , 2006, Nature.

[36]  U. Dohrmann,et al.  Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern. , 2006, Developmental biology.

[37]  Alexander E. Kel,et al.  TRANSFAC® and its module TRANSCompel®: transcriptional gene regulation in eukaryotes , 2005, Nucleic Acids Res..

[38]  Y. Henrotin,et al.  Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. , 2005, Osteoarthritis and cartilage.

[39]  L. Grosenick,et al.  Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages , 2007, Nature.

[40]  M. Wegner,et al.  Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia. , 2003, Human molecular genetics.

[41]  B. de Crombrugghe,et al.  Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. , 2003, Nucleic acids research.

[42]  Yoshihiko Yamada,et al.  Chondrodysplasia of gene knockout mice for aggrecan and link protein , 2002, Glycoconjugate Journal.

[43]  David S. Latchman,et al.  Transcriptional Gene Regulation in Eukaryotes , 2001 .

[44]  Véronique Lefebvre,et al.  A new long form of Sox5 (L‐Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene , 1998, The EMBO journal.

[45]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[46]  L. Sandell,et al.  In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth , 1994, Microscopy research and technique.

[47]  T. Hardingham,et al.  Proteoglycans: many forms and many functions , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[48]  V. Hascall,et al.  Correlated metabolism of proteoglycans and hyaluronic acid in bovine cartilage organ cultures. , 1988, The Journal of biological chemistry.

[49]  G. Kollias,et al.  Position-independent, high-level expression of the human β-globin gene in transgenic mice , 1987, Cell.

[50]  W. C. Forrester,et al.  Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. , 1987, Nucleic acids research.

[51]  D. Heinegård,et al.  The role of the cartilage matrix in osteoarthritis , 2011, Nature Reviews Rheumatology.

[52]  A. Yee,et al.  Structure and function of aggrecan , 2002, Cell Research.

[53]  D. Heinegård,et al.  Age-related changes in the synthesis and mRNA expression of decorin and aggrecan in human meniscus and articular cartilage. , 2001, Osteoarthritis and cartilage.