Hereditary hemolytic anemia due to glucose-6-phosphate dehydrogenase Torrance: a new variant.

Abstract A new variant of glucose-6-phosphate dehydrogenase (G-6-PD) associated with nonspherocytic hemolytic anemia in a Caucasian kindred of Mohawk Indian-Irish ancestry is reported. This variant (G-6-PD Torrance) resembles G-6-PD Chicago but has the unique property of losing most of its activity at pH 8 on dialysis even in the presence of 10 μM TPN. However, it can be reactivated in vitro by 200 μM TPN in the presence of appropriate hydrogen and Mg ++ ion concentrations.

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