The Magnetohydrodynamic Effect and Its Associated Material Designs for Biomedical Applications: A State‐of‐the‐Art Review

The presented article discusses recent advances in biomedical applications of classical Magnetohydrodynamics (MHD), with a focus on operating principles and associated material considerations. These applications address novel approaches to common biomedical problems from micro-particle sorting for lab-on-a-chip devices to advanced physiological monitoring techniques. 100 papers in the field of MHDs were reviewed with a focus on studies with direct biomedical applications. The body of literature was categorized into three primary areas of research including Material Considerations for MHD Applications, MHD Actuation Devices, and MHD Sensing Techniques. The state of the art in the field was examined and research topics were connected to provide a wide view of the field of biomedical MHDs. As this field develops, the need for advanced simulation and material design will continue to increase in importance in order to further expand its reach to maturity. As the field of biomedical MHDs continues to grow, advances towards micro-scale transitions will continue to be made, maintaining its clinically driven nature and moving towards real-world applications.

[1]  C. Laurencin,et al.  Biodegradable polymers as biomaterials , 2007 .

[2]  Frank G Shellock,et al.  Magnetic resonance safety update 2002: Implants and devices , 2002, Journal of magnetic resonance imaging : JMRI.

[3]  Nam-Trung Nguyen,et al.  Micromixers?a review , 2005 .

[4]  A. Lee,et al.  An AC magnetohydrodynamic micropump , 2000 .

[5]  T F Budinger,et al.  Cardiovascular alterations in Macaca monkeys exposed to stationary magnetic fields: experimental observations and theoretical analysis. , 1983, Bioelectromagnetics.

[6]  M.U. Lamperth,et al.  A Modular Approach to MRI-Compatible Robotics , 2008, IEEE Engineering in Medicine and Biology Magazine.

[7]  L. Driel-Gesztelyi.  An Introduction to Magnetohydrodynamics , 2004 .

[8]  Charles Vives,et al.  Local velocity and mass transfer measurements in molten metals using an incorporated magnet probe , 1982 .

[9]  W. Possart,et al.  Preparation of TiO2 layers on cp‐Ti and Ti6Al4V by thermal and anodic oxidation and by sol‐gel coating techniques and their characterization , 2002 .

[10]  Gerald A. Navratil,et al.  Modeling of active control of external magnetohydrodynamic instabilities , 2001 .

[11]  Albert van den Berg,et al.  A high current density DC magnetohydrodynamic (MHD) micropump. , 2005, Lab on a chip.

[12]  Alan Mathewson,et al.  Application of magnetohydrodynamic actuation to continuous flow chemistry. , 2002, Lab on a chip.

[13]  P. Dario,et al.  Design, Fabrication, and Testing of a Capsule With Hybrid Locomotion for Gastrointestinal Tract Exploration , 2010, IEEE/ASME Transactions on Mechatronics.

[14]  Shizhi Qian,et al.  Magnetohydrodynamic flow of RedOx electrolyte , 2005 .

[15]  H. Rack,et al.  Titanium alloys in total joint replacement--a materials science perspective. , 1998, Biomaterials.

[16]  D Stoianovici,et al.  Multi‐imager compatible actuation principles in surgical robotics , 2005, The international journal of medical robotics + computer assisted surgery : MRCAS.

[17]  Abraham P. Lee,et al.  An AC Magnetohydrodynamic Microfluidic Switch for Micro Total Analysis Systems , 2003 .

[18]  Darren R. Laughlin,et al.  A Magnetohydrodynamic Angular Motion Sensor for Anthropomorphic Test Device Instrumentation , 1989 .

[19]  R. Rosa.  Physical Principles of Magnetohydrodynamic Power Generation , 1961 .

[20]  Haim H. Bau,et al.  When MHD-based microfluidics is equivalent to pressure-driven flow , 2011 .

[21]  Albert Mosyak,et al.  Fluid flow in micro-channels , 2005 .

[22]  Nam-Trung Nguyen,et al.  Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale , 2012 .

[23]  R. Streicher,et al.  Joint replacement components made of hot-forged and surface-treated Ti-6Al-7Nb alloy. , 1992, Biomaterials.

[24]  Mitsuo Niinomi,et al.  Mechanical properties of biomedical titanium alloys , 1998 .

[25]  James M. Anderson,et al.  Biological Responses to Materials , 2001 .

[26]  Peter Woias,et al.  Micropumps—past, progress and future prospects , 2005 .

[27]  K. L. Dahm,et al.  The corrosion–wear behaviour of thermally oxidised CP-Ti and Ti–6Al–4V , 2004 .

[28]  L. Fu,et al.  Microfluidic Mixing: A Review , 2011, International journal of molecular sciences.

[29]  Development of an enhanced MHD micromixer based on axial flow modulation , 2010 .

[30]  H. Bau,et al.  A minute magneto hydro dynamic (MHD) mixer , 2001 .

[31]  Odette Fokapu,et al.  Effects of static magnetic field exposure on blood flow , 2009 .

[32]  Shizhi Qian,et al.  Magneto-hydrodynamic stirrer for stationary and moving fluids , 2005 .

[33]  Gari D Clifford,et al.  Comparison of three artificial models of the magnetohydrodynamic effect on the electrocardiogram , 2015, Computer methods in biomechanics and biomedical engineering.

[34]  R. Gassert,et al.  MRI/fMRI-compatible robotic system with force feedback for interaction with human motion , 2006, IEEE/ASME Transactions on Mechatronics.

[35]  Buddy D Ratner,et al.  The catastrophe revisited: blood compatibility in the 21st Century. , 2007, Biomaterials.

[36]  Minghui Yang,et al.  Platinum nanowire nanoelectrode array for the fabrication of biosensors. , 2006, Biomaterials.

[37]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[38]  A. Greiser,et al.  Detailing the use of magnetohydrodynamic effects for synchronization of MRI with the cardiac cycle: A feasibility study , 2012, Journal of magnetic resonance imaging : JMRI.

[39]  Ehud J Schmidt,et al.  3DQRS: A method to obtain reliable QRS complex detection within high field MRI using 12‐lead electrocardiogram traces , 2014, Magnetic resonance in medicine.

[40]  Sam Kassegne,et al.  High-current density DC magenetohydrodynamics micropump with bubble isolation and release system , 2008 .

[41]  Jaesung Jang,et al.  Theoretical and experimental study of MHD (magnetohydrodynamic) micropump , 2000 .

[42]  J. Louis,et al.  Fluid Dynamic Studies with a Magnetohydrodynamic Generator , 1964 .

[43]  N. Peppas,et al.  Present and future applications of biomaterials in controlled drug delivery systems. , 1981, Biomaterials.

[44]  Khellil Sefiane,et al.  Experimental investigation of self-induced thermocapillary convection for an evaporating meniscus in capillary tubes using micro-PIV , 2005 .

[45]  Sven Eckert,et al.  Velocity Measurement Techniques for Liquid Metal Flows , 2007 .

[46]  J M Marston,et al.  Electrical stimulation with Pt electrodes. V. The effect of protein on Pt dissolution. , 1980, Biomaterials.

[47]  Nobuhiko Hata,et al.  Swimming capsule endoscope using static and RF magnetic field of MRI for propulsion , 2008, 2008 IEEE International Conference on Robotics and Automation.

[48]  Nan-Chyuan Tsai,et al.  Review of MEMS-based drug delivery and dosing systems , 2007 .

[49]  Aiqin Hou,et al.  Preparation and characterization of durable antibacterial cellulose biomaterials modified with triazine derivatives , 2009 .

[50]  F G HIRSCH,et al.  The electrical conductivity of blood. I: Relationship to erythrocyte concentration. , 1950, Blood.

[51]  Frank Witte,et al.  Degradable biomaterials based on magnesium corrosion , 2008 .

[52]  Takehiko Toh,et al.  Magnetohydrodynamic calculation for electromagnetic stirring of molten metal , 1998 .

[53]  Arthur R. Weeks,et al.  Simulation of Elevated T-Waves of an ECG Inside a Static Magnetic Field (MRI) , 2008, IEEE Transactions on Biomedical Engineering.

[54]  T. Stan Gregory,et al.  Magnetohydrodynamic-Driven Design of Microscopic Endocapsules in MRI , 2015, IEEE/ASME Transactions on Mechatronics.

[55]  Bethany C Gross,et al.  Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. , 2014, Analytical chemistry.

[56]  Yu Xiang,et al.  A magneto-hydrodynamically controlled fluidic network , 2003 .

[57]  Yu Xiang,et al.  Complex magnetohydrodynamic low-Reynolds-number flows. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[58]  Etienne Burdet,et al.  A 2-DOF fMRI compatible haptic interface to investigate the neural control of arm movements , 2006, Proceedings 2006 IEEE International Conference on Robotics and Automation, 2006. ICRA 2006..

[59]  C H Lorenz,et al.  Novel real‐time R‐wave detection algorithm based on the vectorcardiogram for accurate gated magnetic resonance acquisitions , 1999, Magnetic resonance in medicine.

[60]  Alan V. Sahakian,et al.  Extraction of the magnetohydrodynamic blood flow potential from the surface electrocardiogram in magnetic resonance imaging , 2008, Medical & Biological Engineering & Computing.

[61]  Gari D Clifford,et al.  A 1.5T MRI‐conditional 12‐lead electrocardiogram for MRI and intra‐MR intervention , 2014, Magnetic resonance in medicine.

[62]  T. Chandy,et al.  Use of plasma glow for surface-engineering biomolecules to enhance bloodcompatibility of Dacron and PTFE vascular prosthesis. , 2000, Biomaterials.

[63]  M. Refojo.  Current status of biomaterials in ophthalmology. , 1982, Survey of ophthalmology.

[64]  R. White.  The effect of porosity and biomaterial on the healing and long-term mechanical properties of vascular prostheses. , 1988, ASAIO transactions.

[65]  J. Timmer,et al.  In vitro study to simulate the intracardiac magnetohydrodynamic effect , 2015, Magnetic resonance in medicine.

[66]  Peixiang Cai,et al.  A sensitive nonenzymatic glucose sensor in alkaline media with a copper nanocluster/multiwall carbon nanotube-modified glassy carbon electrode. , 2007, Analytical biochemistry.

[67]  L. Wang,et al.  A magnetohydrodynamic (MHD) microfluidic platform for cell switching , 2005, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology.

[68]  U. Frisch,et al.  Fully developed MHD turbulence near critical magnetic Reynolds number , 1981, Journal of Fluid Mechanics.

[69]  Pei-Jen Wang,et al.  Simulation of two-dimensional fully developed laminar flow for a magneto-hydrodynamic (MHD) pump. , 2004, Biosensors & bioelectronics.

[70]  R. Brown,et al.  Microbial cellulose--the natural power to heal wounds. , 2006, Biomaterials.

[71]  M. Hill,et al.  Micromixing within microfluidic devices. , 2011, Topics in current chemistry.

[72]  B. Picologlou,et al.  Techniques for Measurement of Velocity in Liquid-Metal MHD Flows , 1986 .

[73]  W. Stevenson,et al.  Left-Ventricular Mechanical Activation and Aortic-Arch Orientation Recovered from Magneto-Hydrodynamic Voltages Observed in 12-Lead ECGs Obtained Inside MRIs: A Feasibility Study , 2014, Annals of Biomedical Engineering.

[74]  Shizhi Qian,et al.  Magneto-Hydrodynamics Based Microfluidics. , 2009, Mechanics research communications.

[75]  W. Stevenson,et al.  Rapid quantification of stroke volume using magnetohydrodynamic voltages in 3T MRI: a feasibility study , 2015, Journal of Cardiovascular Magnetic Resonance.

[76]  Shizhi Qian,et al.  A magnetohydrodynamic chaotic stirrer , 2002, Journal of Fluid Mechanics.

[77]  C. Schmidt,et al.  Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. , 2001, Biomaterials.

[78]  D. Williams,et al.  The corrosion behaviour of Ti-6Al-4V, Ti-6Al-7Nb and Ti-13Nb-13Zr in protein solutions. , 1999, Biomaterials.