Neural Expert Systems in Medical Image Interpretation: Development, Use, and Ethical Issues

In this paper, the appropriate level and role of neural network-based methodologies in the development and use of expert systems for medical image interpretation is investigated as technical, organizational, and social issues become intertwined. The notion of the information life cycle is applied to highlight ethical issues during the acquisition, processing and storage, dissemination and use of clinical information. These issues are further analyzed from a stakeholder perspective to accentuate the role of human agents in avoiding ethical risks. Relevant stakeholders, other than the key participants—namely system developers and medical users—are identified. The results of this analysis indicate that each stage of the development and use of a neural expert system entails ethical issues. Significantly, the responsibility for medical image interpretation is affected by contextual factors and should be shared amongst the main stakeholders. These conclusions are useful for the stakeholder groups that are conscious of their obligation to behave ethically and for researchers who wish to investigate further the ethical implications of artificial intelligence use in medicine. tel.: +44-1895-274000 ext. 3745, 2521; fax: +44-1895-251686 e-mail: {Nancy.Pouloudi, George.Magoulas}@brunel.ac.uk

[1]  Yukio Kurihara,et al.  Integration of medical images into the total hospital information system-experiences at Kochi Medical School , 1999, Proceedings of the 32nd Annual Hawaii International Conference on Systems Sciences. 1999. HICSS-32. Abstracts and CD-ROM of Full Papers.

[2]  Eric W. Stein,et al.  A Method to Identify Candidates for Knowledge Acquisition , 1992, J. Manag. Inf. Syst..

[3]  M. Lynne Markus,et al.  Power, politics, and MIS implementation , 1987, CACM.

[4]  James G. Anderson,et al.  Clearing the way for physicians' use of clinical information systems , 1997, CACM.

[5]  Jacobus Ridderikhoff,et al.  Who is afraid of the system? Doctors' attitude towards diagnostic systems , 1999, Int. J. Medical Informatics.

[6]  George D. Magoulas,et al.  Effective Backpropagation Training with Variable Stepsize , 1997, Neural Networks.

[7]  Harry M. Collins,et al.  Artificial experts - social knowledge and intelligent machines , 1990, Inside technology.

[8]  Kenneth M. Ford,et al.  Expertise in context: personally constructed, socially selected and reality-relevant? , 1997 .

[9]  G. D. Magoulas,et al.  Image recognition and neuronal networks: Intelligent systems for the improvement of imaging information , 2000, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy.

[10]  Nikola Kasabov,et al.  Foundations Of Neural Networks, Fuzzy Systems, And Knowledge Engineering [Books in Brief] , 1996, IEEE Transactions on Neural Networks.

[11]  Igor Aleksander,et al.  Introduction to Neural Computing , 1990 .

[12]  Tony Cornford,et al.  The spring model for knowledge-based systems analysis: a case study , 1992, DATB.

[13]  Craig Summers,et al.  Computers, ethics, and collective violence , 1992, J. Syst. Softw..

[14]  E. Mumford,et al.  Managerial expert systems and organizational change: some critical research issues , 1987 .

[15]  Brian R. Gaines,et al.  Knowledge acquisition for knowledge-based systems , 1991, IEEE Expert.

[16]  B Carroll,et al.  Artificial intelligence. Expert systems for clinical diagnosis: are they worth the effort? , 1987, Behavioral science.

[17]  Norman Mooradian,et al.  A Gift of Fire: Social, Legal, and Ethical Issues in Computing , 1998 .

[18]  Florence M. Mason,et al.  Ethics of information management , 1995 .

[19]  Anna Hart,et al.  Knowledge acquisition for expert systems , 1988 .

[20]  Jesse F. Dillard,et al.  Ethical Development of Advanced Technology: A Postmodern Stakeholder Perspective , 1999 .

[21]  George D. Magoulas,et al.  Improving the Convergence of the Backpropagation Algorithm Using Learning Rate Adaptation Methods , 1999, Neural Computation.

[22]  Dale Littler,et al.  Information technology and organizations : strategies, networks, and integration , 1997 .

[23]  James L. McClelland,et al.  Parallel distributed processing: explorations in the microstructure of cognition, vol. 1: foundations , 1986 .

[24]  Tony Cornford,et al.  Developing Information Systems , 1998 .

[25]  Vimla L. Patel,et al.  Cognitive evaluation of decision making processes and assessment of information technology in medicine , 1998, Int. J. Medical Informatics.

[26]  I M Chen,et al.  Automation of colonoscopy. Part II: Visual-control aspects. , 1998, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[27]  Carl G. Looney,et al.  Pattern recognition using neural networks , 1997 .

[28]  Ben Essex Doctors, Dilemmas, Decisions , 1994 .

[29]  Maureen Firlej,et al.  Knowledge elicitation - a practical handbook , 1991 .

[30]  Yao Wang,et al.  A wavelet-based multiresolution regularized least squares reconstruction approach for optical tomography , 1997, IEEE Transactions on Medical Imaging.

[31]  Hubert L. Dreyfus,et al.  Mind over Machine: The Power of Human Intuition and Expertise in the Era of the Computer , 1987, IEEE Expert.

[32]  Athanasia Pouloudi,et al.  Information technology for collaborative advantage in healthcare revisited , 1999, Inf. Manag..

[33]  Robert Ivor John,et al.  Application of the fuzzy ART/MAP and MinMax/MAP neural network models to radiographic image classification , 1997, Artif. Intell. Medicine.

[34]  M. Harris,et al.  Fibre optic confocal imaging (FOCI) for subsurface microscopy of the colon in vivo. , 1994, Journal of anatomy.

[35]  Annabel C. Beerel,et al.  Expert systems: strategic implications and applications , 1987 .

[36]  Ina Wagner,et al.  A web of fuzzy problems: confronting the ethical issues , 1993, CACM.

[37]  Fergus Bolger,et al.  Cognitive expertise research and knowledge engineering , 1995, The Knowledge Engineering Review.

[38]  Chee Keong Kwoh,et al.  Probabilistic reasoning from correlated objective data , 1995 .

[39]  Geoff Walsham,et al.  Interpreting Information Systems in Organizations , 1993 .

[40]  Drasko Furundzic,et al.  Neural networks approach to early breast cancer detection , 1998, J. Syst. Archit..

[41]  Yan Zhu,et al.  Computerized tumor boundary detection using a Hopfield neural network , 1997, IEEE Transactions on Medical Imaging.

[42]  Hubert L. Dreyfus,et al.  Misrepresenting Human Intelligence , 1986 .