A “Trans” Perspective on the Control of Immunoglobulin C Gene Expression

The control of immunoglobulin (Ig) C gene expression is, for molecular biologists, a question DNA recombination or RNA processing, while for immunologists it is the class specificity in the antibody responses to structurally different antigens. For cell biologists, it might be a problem of regulating membrane-associated versus secretory forms of a protein, or growth versus maturation in clonal progenies. It is, overall, a question of cell differentiation, and for allofusitprovidesa very simple system-eight genes of known structure and eight products easily identifiable yet one that is most attractive, as it may offer one of the first model systems in biology in which DNA recombination is directly induced by well-defined signals. In addition, it also appears to be one of the areas in basic immunobiology closest to providing direct application of fundamental principles to clinical practice.

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