Glucose‐sensitive holographic sensors

Holographic sensors for monitoring glucose were fabricated from hydrogel films containing chemical ligands based on phenylboronic acid. The films were transformed into reflection holograms using a diffusion method coupled with exposure to laser light. The diffraction wavelength of the holograms was used to monitor the swelling of the hydrogel film in the presence of glucose. Fully reversible changes in diffraction wavelength were demonstrated, highlighting the potential for using these holograms as glucose sensors. Copyright © 2004 John Wiley & Sons, Ltd.

[1]  W. Scouten,et al.  Synthesis and structural investigation of two potential boronate affinity chromatography ligands catechol [2-(diisopropylamino)carbonyl]phenylboronate and catechol [2-(diethylamino)carbonyl, 4-methyl]phenylboronate , 1995 .

[2]  W. H. Elliott,et al.  Data for Biochemical Research , 1986 .

[3]  J. Frederiksen,et al.  A New Glucose-Selective Fluorescent Bisboronic Acid. First Report of Strong α-Furanose Complexation in Aqueous Solution at Physiological pH1 , 1999 .

[4]  Michael S Freund,et al.  Potentiometric saccharide detection based on the pK(a) changes of poly(aniline boronic acid). , 2002, Journal of the American Chemical Society.

[5]  T. Okano,et al.  Glucose-Responsive Gel from Phenylborate Polymer and Poly (Vinyl Alcohol): Prompt Response at Physiological pH Through the Interaction of Borate with Amino Group in the Gel , 1997, Pharmaceutical Research.

[6]  Jeff Blyth,et al.  pH-sensitive holographic sensors. , 2003, Analytical chemistry.

[7]  Jeff Blyth,et al.  A Holographic Alcohol Sensor , 1999 .

[8]  S. Shinkai,et al.  Novel nucleotide‐responsive hydrogels designed from copolymers of boronic acid and cationic units and their applications as a QCM resonator system to nucleotide sensing , 2000 .

[9]  C. Lowe,et al.  A holographic sensor based on a rationally designed synthetic polymer , 1998, Journal of molecular recognition : JMR.

[10]  Igor K Lednev,et al.  Photonic crystal carbohydrate sensors: low ionic strength sugar sensing. , 2003, Journal of the American Chemical Society.

[11]  C. Lowe,et al.  A hologram biosensor for proteases , 1996 .

[12]  C. Lowe,et al.  Holographic sensor for water in solvents. , 1996, Analytical chemistry.

[13]  T. Okano,et al.  Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH , 1995 .

[14]  C. Lowe,et al.  A Holographic Sensor for Proteases , 1995 .