The frequency of thyroid autoimmunity in behcet's disease in mid-anatolian region of Turkey

Aim: Behcet’s disease is considered a vasculitis triggered by immunological mechanisms; however its pathogenesis has not been elucidated. The thyroid autoimmune disease frequently coexists with various autoimmune conditions. Studies on the effect of Behcet’s disease on this gland are limited. The present study aimed to examine the presence of thyroid autoimmunity in Behset’s Disease, which has been recently regarded as an autoimmune disease. Material and Methods: The study included 45 patients diagnosed with Behcet’s disease according to the criteria of the International Study Group, and 42 healthy individuals. The levels of FT3, FT4, TSH, thyroglobulin autoantibody (anti-TG) and anti-thyroid peroxidase antibody (anti-TPO), and results of thyroid ultrasonography were examined in all patients and healthy individuals. Results: No significant difference was found in the levels of FT3, TSH and thyroid autoantibodies (anti-TG, anti-TPO) of thyroid function tests between the two groups. FT4 levels were significantly higher in patients with Behcet’s disease compared to the control group (p=0.029). Conclusion: The present study showed that there was no concomitant autoimmune thyroid disease in patients with Behcet’s disease. However, we believe that the vasculitis process might have an impact on parenchyma of the thyroid since FT4 levels were significantly higher in patients, and thus parenchyma of the thyroid should be examined thoroughly in patients with Behcet’s disease.

[1]  A. Antonelli,et al.  Incidence of thyroid disorders in systemic sclerosis: results from a longitudinal follow-up. , 2013, The Journal of clinical endocrinology and metabolism.

[2]  K. Kayataş,et al.  Thyroid Autoimmunity and Behçet's Disease: Is There a Significant Association? , 2013, TheScientificWorldJournal.

[3]  B. Begović,et al.  Association between Vitiligo and Thyroid Autoimmunity , 2011, Journal of thyroid research.

[4]  S. Gangemi,et al.  Urticaria and thyroid autoimmunity. , 2011, Thyroid : official journal of the American Thyroid Association.

[5]  Z. Tazi-Mezalek,et al.  [Vascular involvement in Behcet's disease]. , 2009, La Revue de medecine interne.

[6]  G. Harifi,et al.  [Primary Gougerot-Sjögren syndrome and Behçet disease: association or coincidence?]. , 2009, Presse medicale.

[7]  E. Thomas,et al.  ALOPECIA AREATA AND AUTOIMMUNITY: A CLINICAL STUDY , 2008, Indian journal of dermatology.

[8]  E. Kasumagić-Halilović.  Thyroid autoimmunity in patients with alopecia areata. , 2008, Acta dermatovenerologica Croatica : ADC.

[9]  R. Ersoy,et al.  The Thyroid in Behcet ’ s Disease : Hormonal and Ultrasonographic Findings , 2007 .

[10]  N. Onsun,et al.  Association between chronic urticaria and thyroid autoimmunity. , 2006, European journal of dermatology : EJD.

[11]  Sung Bin Cho,et al.  Coexistence of Behçet's Disease and Autoimmune Disease: Clinical Features of 11 Cases , 2005, The Journal of dermatology.

[12]  A. Gül.  Behçet's disease as an autoinflammatory disorder. , 2005, Current drug targets. Inflammation and allergy.

[13]  E. Iliev,et al.  Thyroid autoimmunity in children and adolescents with alopecia areata , 2004, International journal of dermatology.

[14]  M. Rottem.  Chronic urticaria and autoimmune thyroid disease: is there a link? , 2003, Autoimmunity reviews.

[15]  G. Deleonardi,et al.  Thyroid autoimmunity in chronic urticaria. , 2001, Allergy and asthma proceedings.

[16]  K. Aksu,et al.  Thyroid functions in Behçet's disease. , 1999, Clinical endocrinology.

[17]  H. Yazici.  The place of Behçet's syndrome among the autoimmune diseases. , 1997, International reviews of immunology.

[18]  Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease. , 1990, Lancet.

[19]  E. Atra,et al.  [Behcet's syndrome]. , 1968, Revista paulista de medicina.