Micro-device combining electrophysiology and optical imaging for functional brain monitoring in freely moving animals

Monitoring brain activities in awake and freely moving status is very important in physiological and pathological studies of brain functions. In this study, we developed a new standalone micro-device combining electrophysiology and optical imaging for monitoring the cerebral blood flow and neural activities with more feasibility for freely moving animals.

[1]  Eric A Newman,et al.  Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling , 2006, The Journal of Neuroscience.

[2]  John J. McAuliffe,et al.  The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory , 2009, Anesthesia and analgesia.

[3]  J D Briers,et al.  Laser speckle contrast analysis (LASCA): a nonscanning, full-field technique for monitoring capillary blood flow. , 1996, Journal of biomedical optics.

[4]  Nitish V. Thakor,et al.  Laser speckle contrast reveals cerebral blood flow dynamics evoked by optogenetically controlled neuronal activity , 2013, Photonics West - Biomedical Optics.

[5]  D. Kleinfeld,et al.  Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  Nitish V Thakor,et al.  Chronic wide-field imaging of brain hemodynamics in behaving animals. , 2017, Biomedical optics express.

[7]  T. Poggio,et al.  Object Selectivity of Local Field Potentials and Spikes in the Macaque Inferior Temporal Cortex , 2006, Neuron.

[8]  Weizhao Zhao,et al.  Experimental intracerebral hemorrhage in the mouse: histological, behavioral, and hemodynamic characterization of a double-injection model. , 2003, Stroke.

[9]  S. Tong,et al.  Laser speckle contrast imaging of cerebral blood flow in freely moving animals. , 2011, Journal of biomedical optics.

[10]  Peng Miao,et al.  In-vivo brain blood flow imaging based on laser speckle contrast imaging and synchrotron radiation microangiography , 2014 .

[11]  C. Iadecola,et al.  Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. , 2006, Journal of applied physiology.

[12]  Nitish V. Thakor,et al.  Random process estimator for laser speckle imaging of cerebral blood flow , 2009, Optics express.

[13]  M. Carandini,et al.  Local Origin of Field Potentials in Visual Cortex , 2009, Neuron.

[14]  E. Su,et al.  Tissue plasminogen activator‐mediated PDGF signaling and neurovascular coupling in stroke , 2009, Journal of thrombosis and haemostasis : JTH.

[15]  D. Boas,et al.  Laser speckle contrast imaging in biomedical optics. , 2010, Journal of biomedical optics.

[16]  C. Stosiek,et al.  In vivo two-photon calcium imaging of neuronal networks , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Shanbao Tong,et al.  Influences of hypothermia on the cortical blood supply by laser speckle imaging. , 2009, IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[18]  S. Bressler,et al.  Response preparation and inhibition: The role of the cortical sensorimotor beta rhythm , 2008, Neuroscience.

[19]  Rajesh P. N. Rao,et al.  Electrocorticography-based brain computer Interface-the seattle experience , 2006, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[20]  R. Flink,et al.  Intraoperative electrocorticography in epilepsy surgery: useful or not? , 2003, Seizure.

[21]  S. Baker.  Oscillatory interactions between sensorimotor cortex and the periphery , 2007, Current Opinion in Neurobiology.

[22]  Ofer Levi,et al.  Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system. , 2016, Biomedical optics express.

[23]  Nitish V. Thakor,et al.  High Resolution Cerebral Blood Flow Imaging by Registered Laser Speckle Contrast Analysis , 2010, IEEE Transactions on Biomedical Engineering.

[24]  Zhen Chao,et al.  Entropy analysis reveals a simple linear relation between laser speckle and blood flow. , 2014, Optics letters.

[25]  R. Barry,et al.  A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography , 2003, Clinical Neurophysiology.