Absolute configuration of the four stereoisomers of valnoctamide (2-ethyl-3-methyl valeramide), a potentially new stereospecific antiepileptic and CNS drug

[1]  H. Nau,et al.  Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid , 1998, Epilepsy Research.

[2]  E. Perucca,et al.  Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and in patients with epilepsy , 1997, Clinical pharmacology and therapeutics.

[3]  E. J. Ariëns.  Nonchiral, homochiral and composite chiral drugs. , 1993, Trends in pharmacological sciences.

[4]  K. Mori,et al.  Synthesis of the three stereoisomers of auxin-glutaric acid to confirm the non-existence of Kögl's auxin-a and -b , 1991 .

[5]  G. Tucker,et al.  Enantiomer specific pharmacokinetics. , 1990, Pharmacology & therapeutics.

[6]  M. Eichelbaum,et al.  Pharmacokinetic and pharmacodynamic consequences of stereoselective drug metabolism in man. , 1988, Biochemical pharmacology.

[7]  Davidr . Evans,et al.  Contrasteric carboximide hydrolysis with lithium hydroperoxide , 1987 .

[8]  B. Koppenhoefer,et al.  A Useful Route to (R)-Alkyloxiranes of Defined Enantiomeric Purity from (S)-Amino Acids , 1982 .

[9]  Davidr . Evans,et al.  Asymmetric alkylation reactions of chiral imide enolates. A practical approach to the enantioselective synthesis of .alpha.-substituted carboxylic acid derivatives , 1982 .

[10]  P. Pfeffer,et al.  .alpha. Anions of carboxylic acids. II. Formation and alkylation of .alpha.-metalated aliphatic acids , 1972 .

[11]  H. Brown,et al.  Oxidation of secondary alcohols in diethyl ether with aqueous chromic acid. Convenient procedure for the preparation of ketones in high epimeric purity , 1971 .