Effect of doxycycline concentrations in chicken tissues as a consequence of permanent exposure to enrofloxacin traces in drinking water

Abstract Introduction: The main problem in poultry farming is the difficulty in producing food of animal origin without using antibacterial agents. Because most antibacterial compounds are dispensed in water, some water supply systems can be contaminated by antibiotics which are then administered to the animals unintentionally. This can lead to unexpected increases in antibiotic residues in food of animal origin. The aim of the present study was to determine whether the constant exposure of chicken broilers to enrofloxacin affects the withdrawal time of a therapeutic doxycycline that is intentionally administered to the chickens. Material and Methods: The concentrations of doxycycline, enrofloxacin, and ciprofloxacin were determined by LC-MS/MS in muscles and liver of the chickens. Results: Doxycycline residue concentrations in the chicken tissues from the group that received trace amounts of enrofloxacin were nearly 50% greater than those of the group that received only doxycycline. Conclusion: These results indicated that constant exposure to enrofloxacin in trace amounts significantly influences the residual doxycycline concentration in chicken tissues.

[1]  M. Landoni,et al.  The use of antimicrobial agents in broiler chickens. , 2015, Veterinary journal.

[2]  A. Gajda,et al.  Doxycycline depletion and residues in eggs after oral administration to laying hens , 2015, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[3]  A. Gajda,et al.  LC-MS/MS analysis of doxycycline residues in chicken tissues after oral administration , 2014 .

[4]  A. Posyniak,et al.  Multi-residue determination of antibiotics in fish by liquid chromatography-tandem mass spectrometry , 2013, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[5]  G. Christodoulopoulos,et al.  RESIDUES DEPLETION STUDY AND WITHDRAWAL PERIOD DETERMINATION OF SULPHADIAZINE AND TRIMETHOPRIM PREMIX IN PIGS , 2013 .

[6]  S. Croubels,et al.  Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due to cross-contamination of feed , 2012, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[7]  D. Donoghue,et al.  The relationship between blood and muscle samples to monitor for residues of the antibiotic enrofloxacin in chickens. , 2011, Poultry science.

[8]  A. Amer,et al.  Pharmacokinetic and tissue distribution of doxycycline in broiler chickens pretreated with either: diclazuril or halofuginone. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[9]  P. Charles,et al.  Safety and Efficacy Review of Doxycycline , 2009 .

[10]  J. Castañon,et al.  History of the use of antibiotic as growth promoters in European poultry feeds. , 2007, Poultry science.

[11]  T. Ogata,et al.  Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in dogs. , 2005, American journal of veterinary research.

[12]  V. Sureshkumar,et al.  Interaction between enrofloxacin and monensin in broiler chickens. , 2004, Veterinary and human toxicology.

[13]  J. Blondeau.  Fluoroquinolones: mechanism of action, classification, and development of resistance. , 2004, Survey of ophthalmology.

[14]  M. Atef,et al.  Influence of aflatoxin B1 on the kinetic disposition, systemic bioavailability and tissue residues of doxycycline in chickens , 2002, British poultry science.

[15]  M. Rantala,et al.  Efficacy and pharmacokinetics of enrofloxacin and flunixin meglumine for treatment of cows with experimentally induced Escherichia coli mastitis. , 2002, Journal of veterinary pharmacology and therapeutics.

[16]  R. Stahlmann.  Clinical toxicological aspects of fluoroquinolones. , 2002, Toxicology letters.

[17]  D. Kennedy,et al.  Regulatory problems caused by contamination, a frequently overlooked cause of veterinary drug residues. , 2000, Journal of chromatography. A.

[18]  R. Renterghem,et al.  Validation of HPLC method of analysis of tetracycline residues in eggs and broiler meat and its application to a feeding trial. , 1999 .

[19]  C. V. Van Peteghem,et al.  Liquid chromatographic separation of doxycycline and 4-epidoxycycline in a tissue depletion study of doxycycline in turkeys. , 1998, Journal of chromatography. B, Biomedical sciences and applications.

[20]  V. Pm,et al.  In vitro and in vivo study of the effects of enrofloxacin on hepatic cytochrome P-450. Potential for drug interactions. , 1996 .

[21]  P. de Backer,et al.  Validation of a high-performance liquid chromatographic method for the determination of doxycycline in turkey plasma. , 1996, Journal of chromatography. B, Biomedical applications.

[22]  S. Bertini,et al.  Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the beagle dog. , 1995, Journal of veterinary pharmacology and therapeutics.

[23]  R. Polk,et al.  Pharmacokinetic Drug Interactions with Antimicrobial Agents , 1993, Clinical pharmacokinetics.

[24]  M. J. Novotny,et al.  Effect of enrofloxacin on digoxin clearance and steady-state serum concentrations in dogs. , 1991, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[25]  A. Posyniak,et al.  Liquid chromatography-tandem mass spectrometry multiclass method for the determination of antibiotics residues in water samples from water supply systems in food-producing animal farms. , 2015, Chemosphere.

[26]  M. Pigłowski.  The Alert Notifications for Products from the European Economic Area and other Countries in the Rapid Alert System for Food and Feed (RASFF) , 2015 .

[27]  A. Posyniak,et al.  Multiresidue determination of antibiotics in fish samples by liquid chromatography-tandem mass spectrometry. [Conference poster]. , 2012 .

[28]  A. Gajda,et al.  MULTI-CLASS PROCEDURE FOR ANALYSIS OF ANTIBACTERIAL COMPOUNDS IN ANIMAL TISSUES BY LIQUID CHROMATOGRAPHY- TANDEM MASS SPECTROMETRY , 2011 .

[29]  S. Soback,et al.  Interaction of Fluoroquinolones and Certain Ionophores in Broilers: Effect on Blood Levels and Hepatic Cytochrome P450 Monooxygenase Activity , 2001, Drug metabolism and drug interactions.

[30]  J. Babish,et al.  In vitro and in vivo study of the effects of enrofloxacin on hepatic cytochrome P-450. Potential for drug interactions. , 1996, Veterinary and human toxicology.

[31]  A. J. Wright,et al.  The fluoroquinolones , 1991, Mayo Clinic proceedings.