Retinotopic organization of human visual cortex: departures from the classical model.

Retinotopic mapping strategies similar to those used for invasive electrophysiological studies to identify multiple visual areas in monkeys have been adapted for noninvasive studies in humans, using magnetic recordings of brain activity in conjunction with anatomical magnetic resonance imaging. The retinotopic organization of the primary visual area (V1) in the left hemisphere of human subjects was examined by presenting a small patterned stimuli near the vertical and horizontal meridians in the lower right visual field. In contrast with the classical model of V1 retinotopy, our results suggest that the representation of the horizontal meridian does not necessarily correspond in a one-to-one manner with the base of the calcarine fissure and that some lower field stimuli can activate regions in the lower bank of the fissure. The results also indicate significant individual variability in the details of how V1 maps around the calcarine fissure.

[1]  H Spekreijse,et al.  The extrastriate generators of the EP to checkerboard onset. A source localization approach. , 1991, Electroencephalography and clinical neurophysiology.

[2]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[3]  D. Ts'o,et al.  Functional organization of primate visual cortex revealed by high resolution optical imaging. , 1990, Science.

[4]  N. J. David,et al.  Occipital lobe infarctions , 1981, Neurology.

[5]  P. S. Lewis,et al.  Monte Carlo Analysis of Localization Errors in Magnetoencephalography , 1989 .

[6]  W. Dobelle,et al.  Phosphenes produced by electrical stimulation of human occipital cortex, and their application to the development of a prosthesis for the blind , 1974, The Journal of physiology.

[7]  B. Cragg.  The topography of the afferent projections in the circumstriate visual cortex of the monkey studied by the Nauta method. , 1969, Vision research.

[8]  J. E. Glynn,et al.  Numerical Recipes: The Art of Scientific Computing , 1989 .

[9]  Frederick C. Cordes,et al.  The Vertebrate Visual System, Stephen Polyak (Ed.). the University of Chicago Press, Chicago (1957), 1390, 546 illustrations, index, bibliography. Price: $45.00. , 1958 .

[10]  Jonathan D. Cohen,et al.  Functional topographic mapping of the cortical ribbon in human vision with conventional MRI scanners , 1993, Nature.

[11]  R. Ilmoniemi,et al.  Estimates of visually evoked cortical currents. , 1992, Electroencephalography and clinical neurophysiology.

[12]  S. Zeki.  Functional specialisation in the visual cortex of the rhesus monkey , 1978, Nature.

[13]  John S. George,et al.  MRIVIEW: An interactive computational tool for investigation of brain structure and function , 1993, Proceedings Visualization '93.

[14]  W. H. Dobelle,et al.  The topography and variability of the primary visual cortex in man. , 1974, Journal of neurosurgery.

[15]  S. Supek,et al.  Simulation studies of multiple dipole neuromagnetic source localization: model order and limits of source resolution , 1993, IEEE Transactions on Biomedical Engineering.

[16]  S. Zeki.  Representation of central visual fields in prestriate cortex of monkey. , 1969, Brain research.

[17]  M. Hämäläinen,et al.  Feasibility of the homogeneous head model in the interpretation of neuromagnetic fields. , 1987, Physics in medicine and biology.

[18]  D. V. van Essen,et al.  The pattern of interhemispheric connections and its relationship to extrastriate visual areas in the macaque monkey , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[19]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  C J Aine,et al.  Temporal dynamics of visual-evoked neuromagnetic sources: effects of stimulus parameters and selective attention. , 1995, The International journal of neuroscience.

[21]  A. Cowey,et al.  The ganglion cell and cone distributions in the monkey's retina: Implications for central magnification factors , 1985, Vision Research.

[22]  Ronald P. Crick,et al.  The Representation of the Visual Field , 1983 .

[23]  Karl J. Friston,et al.  A direct demonstration of functional specialization in human visual cortex , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[24]  R. W. Russell,et al.  Correlation of CAT scan and visual field defects in vascular lesions of the posterior visual pathways. , 1979, Journal of neurology, neurosurgery, and psychiatry.

[25]  A. Cowey,et al.  The ganglion cell and cone distributions in the monkey's retina: Implications for central magnification factors , 1986, Behavioural Brain Research.

[26]  B.N. Cuffin,et al.  Effects of head shape on EEGs and MEGs , 1990, IEEE Transactions on Biomedical Engineering.

[27]  Richard S. J. Frackowiak,et al.  Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. , 1993, Cerebral cortex.

[28]  J M K SPALDING,et al.  WOUNDS OF THE VISUAL PATHWAY , 1952, Journal of neurology, neurosurgery, and psychiatry.

[29]  B. Rosen,et al.  Functional mapping of the human visual cortex by magnetic resonance imaging. , 1991, Science.

[30]  S. Clarke,et al.  Occipital cortex in man: Organization of callosal connections, related myelo‐ and cytoarchitecture, and putative boundaries of functional visual areas , 1990, The Journal of comparative neurology.

[31]  D. Whitteridge,et al.  The representation of the visual field on the cerebral cortex in monkeys , 1961, The Journal of physiology.

[32]  J. Horton,et al.  The representation of the visual field in human striate cortex. A revision of the classic Holmes map. , 1991, Archives of ophthalmology.

[33]  G. Holmes.  Ferrier Lecture - The organization of the visual cortex in man , 1945, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[34]  D. V. van Essen,et al.  Retinotopic organization of human visual cortex mapped with positron- emission tomography , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.