Analysis of COVID-19 Prevention and Control Effects Based on the SEITRD Dynamic Model and Wuhan Epidemic Statistics

Since December 2019, millions of people worldwide have been diagnosed with COVID-19, which has caused enormous losses. Given that there are currently no effective treatment or prevention drugs, most countries and regions mainly rely on quarantine and travel restrictions to prevent the spread of the epidemic. How to find proper prevention and treatment methods has been a hot topic of discussion. The key to the problem is to understand when these intervention measures are the best strategies for disease control and how they might affect disease dynamics. In this paper, we build a transmission dynamic model in combination with the transmission characteristics of COVID-19. We thoroughly study the dynamical behavior of the model and analyze how to determine the relevant parameters, and how the parameters influence the transmission process. Furthermore, we subsequently compare the impact of different control strategies on the epidemic, the variables include intervention time, control duration, control intensity, and other model parameters. Finally, we can find a better control method by comparing the results under different schemes and choose the proper preventive control strategy according to the actual epidemic stage and control objectives.

[1]  Yong Han Kang,et al.  Optimal strategy of vaccination & treatment in an SIR epidemic model , 2017, Math. Comput. Simul..

[2]  Md. Haider Ali Biswas,et al.  A SEIR model for control of infectious diseases with constraints , 2014 .

[3]  TRANSMISSION DYNAMICS AND CONTROL STRATEGIES OF COVID-19 IN WUHAN, CHINA , 2020 .

[4]  Marta C. González,et al.  Hand-hygiene mitigation strategies against global disease spreading through the air transportation network , 2019, bioRxiv.

[5]  C. Zheng,et al.  Stabilization and Optimal Control of the SEITR Epidemic Model with Vaccination , 2018, 2018 37th Chinese Control Conference (CCC).

[6]  Jianhong Wu,et al.  Estimation of the Transmission Risk of the 2019-nCoV and Its Implication for Public Health Interventions , 2020, Journal of clinical medicine.

[7]  G. P. Samanta,et al.  Stability analysis and optimal control of an epidemic model with vaccination , 2015 .

[8]  B. Allegranzi,et al.  'Clean care for all - it's in your hands': the 5th May 2019 World Health Organization SAVE LIVES: Clean Your Hands campaign. , 2019, The Journal of hospital infection.

[9]  Qingchu Wu,et al.  Responsive immunization and intervention for infectious diseases in social networks , 2014, Chaos.

[10]  Soyoung Kim,et al.  Mathematical model and intervention strategies for mitigating tuberculosis in the Philippines. , 2018, Journal of theoretical biology.

[11]  Eunha Shim,et al.  Optimal strategies of social distancing and vaccination against seasonal influenza. , 2013, Mathematical biosciences and engineering : MBE.

[12]  Anupama Sharma,et al.  Stability analysis and optimal control of an epidemic model with awareness programs by media , 2015, Biosyst..

[13]  Seid Miad Zandavi,et al.  Forecasting the Spread of Covid-19 Under Control Scenarios Using LSTM and Dynamic Behavioral Models , 2020, ArXiv.

[14]  Fatih Safa Erenay,et al.  Optimal distribution of the influenza vaccine , 2014, Proceedings of the Winter Simulation Conference 2014.

[15]  Zhi-Hong Guan,et al.  Epidemic spreading on networks with overlapping community structure , 2012 .

[16]  G. Leung,et al.  Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study , 2020, The Lancet.

[17]  P. Colaneri,et al.  Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy , 2020, Nature Medicine.

[18]  Shicheng Yu,et al.  Estimation of incubation period distribution of COVID-19 using disease onset forward time: a novel cross-sectional and forward follow-up study , 2020, Science Advances.

[19]  Anuj Kumar,et al.  Vaccination and treatment as control interventions in an infectious disease model with their cost optimization , 2017, Commun. Nonlinear Sci. Numer. Simul..

[20]  J. Remon,et al.  One-step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[21]  Kazeem O. Okosun,et al.  Optimal control strategies and cost-effectiveness analysis of a malaria model , 2013, Biosyst..

[22]  Yu Jiang,et al.  A time delay dynamical model for outbreak of 2019-nCoV and the parameter identification , 2020, Journal of Inverse and Ill-posed Problems.

[23]  T. K. Kar,et al.  Stability analysis and optimal control of an SIR epidemic model with vaccination , 2011, Biosyst..

[24]  Eunok Jung,et al.  Mathematical model of transmission dynamics and optimal control strategies for 2009 A/H1N1 influenza in the Republic of Korea. , 2017, Journal of theoretical biology.

[25]  G. Leung,et al.  Nowcasting and forecasting the Wuhan 2019-nCoV outbreak , 2020 .

[26]  Mel Krajden,et al.  Modeling Control Strategies of Respiratory Pathogens , 2005, Emerging infectious diseases.

[27]  A. M. Edwards,et al.  Estimating the impact of COVID-19 control measures using a Bayesian model of physical distancing , 2020, medRxiv.

[28]  L. Yang,et al.  Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak , 2020, International Journal of Infectious Diseases.

[29]  J. Wang,et al.  Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of China’s Prevention and Control Strategy for the COVID-19 Epidemic , 2020, International journal of environmental research and public health.