Associations between ambient air pollution and daily mortality among persons with congestive heart failure.

We conducted a mortality time series study to investigate the association between daily mortality for congestive heart failure (CHF), and daily concentrations of particles and gaseous pollutants in the ambient air of Montreal, Quebec, during the period 1984-1993. In addition, using data from the universal Quebec Health Insurance Plan, we identified individuals >/=65 years of age who, one year before death, had a diagnosis of CHF. Fixed-site air pollution monitors in Montreal provided daily mean levels of pollutants. We regressed the logarithm of daily counts of mortality on the daily mean levels of each pollutant, after accounting for seasonal and subseasonal fluctuations in the mortality time series, non-Poisson dispersion, weather variables, and other gaseous and particle pollutants. Using cause of death information, we did not find any associations between daily mortality for CHF and any air pollutants. The analyses of CHF defined from the medical record showed positive associations with coefficient of haze, the extinction coefficient, SO(2), and NO(2). For example, the mean percent increase in daily mortality for an increase in the coefficient of haze across the interquartile range was 4.32% (95% CI: 0.95-7.80%) and for NO(2) it was 4.08% (95% CI: 0.59-7.68%). These effects were generally higher in the warm season.

[1]  R. Burnett,et al.  Inhalation toxicology of urban ambient particulate matter: acute cardiovascular effects in rats. , 2001, Research report.

[2]  R. D. Morris,et al.  Carbon monoxide and hospital admissions for congestive heart failure: evidence of an increased effect at low temperatures. , 1998, Environmental health perspectives.

[3]  D Krewski,et al.  Association between Ambient Carbon Monoxide Levels and Hospitalizations for Congestive Heart Failure in the Elderly in 10 Canadian Cities , 1997, Epidemiology.

[4]  P. Saldiva,et al.  Pulmonary emphysema induced by passive smoking: an experimental study in rats. , 1997, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[5]  D. Giannessi,et al.  The role of endothelins and their receptors in heart failure. , 2001, Pharmacological research.

[6]  J A Hanley,et al.  Estimation of unmeasured particulate air pollution data for an epidemiological study of daily respiratory morbidity. , 1994, Environmental research.

[7]  L. Chiazze,et al.  Accuracy of death certification in an autopsied population with specific attention to malignant neoplasms and vascular diseases. , 1980, American journal of epidemiology.

[8]  B. Harris Spectral Analysis Of Time Series , 1967 .

[9]  Joel Schwartz,et al.  REVIEW OF EPIDEMIOLOGICAL EVIDENCE OF HEALTH EFFECTS OF PARTICULATE AIR POLLUTION , 1995 .

[10]  A. Lerman,et al.  Endothelin in cardiovascular disease: from atherosclerosis to heart failure. , 2000, Journal of cardiovascular pharmacology.

[11]  W. MacNee,et al.  Particulate air pollution and acute health effects , 1995, The Lancet.

[12]  R. D. Morris,et al.  Air pollution and hospital admissions for cardiovascular disease in Detroit, Michigan. , 1995, American journal of epidemiology.

[13]  R. D. Morris,et al.  Ambient air pollution and hospitalization for congestive heart failure among elderly people in seven large US cities. , 1995, American journal of public health.

[14]  J. Schwartz,et al.  Particulate air pollution and daily mortality in Detroit. , 1991, Environmental research.

[15]  U. Kodavanti,et al.  Rodent models of cardiopulmonary disease: their potential applicability in studies of air pollutant susceptibility. , 1998, Environmental health perspectives.

[16]  G. Pershagen,et al.  Effects of Ambient Air Pollution on Daily Mortality in a Cohort of Patients with Congestive Heart Failure , 2001, Epidemiology.

[17]  D. Fukai,et al.  Prognostic value of plasma soluble intercellular adhesion molecule-1 and endothelin-1 concentration in patients with chronic congestive heart failure. , 1995, The American journal of cardiology.

[18]  J. Kaski,et al.  Increased plasma endothelin levels in angina patients with rapid coronary artery disease progression. , 2001, European heart journal.

[19]  J. Schwartz,et al.  Particulate air pollution and mortality: more than the Philadelphia story. , 1995, Epidemiology.

[20]  P. Kinney,et al.  Associations of daily mortality and air pollution in Los Angeles County. , 1991, Environmental research.

[21]  D V Bates,et al.  Health indices of the adverse effects of air pollution: the question of coherence. , 1992, Environmental research.

[22]  J C Bailar,et al.  The association between daily mortality and ambient air particle pollution in Montreal, Quebec. 2. Cause-specific mortality. , 2001, Environmental research.

[23]  J. Kastrup,et al.  Plasma endothelin in congestive heart failure: a predictor of cardiac death? , 1996, Journal of cardiac failure.

[24]  O. Smiseth,et al.  Regulation of ET: pulmonary release of ET contributes to increased plasma ET levels and vasoconstriction in CHF. , 2000, American journal of physiology. Heart and circulatory physiology.

[25]  I. Adamson,et al.  Acute effects of inhaled urban particles and ozone: lung morphology, macrophage activity, and plasma endothelin-1. , 1998, The American journal of pathology.

[26]  P J Catalano,et al.  Gaseous pollutants in particulate matter epidemiology: confounders or surrogates? , 2001, Environmental health perspectives.

[27]  F. Dominici,et al.  On the use of generalized additive models in time-series studies of air pollution and health. , 2002, American journal of epidemiology.

[28]  M. Lebowitz,et al.  Air pollution and hospital admissions for cardiovascular disease. , 1998, Epidemiology.

[29]  F. Ruschitzka,et al.  Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? , 2001, Journal of the American College of Cardiology.

[30]  J C Bailar,et al.  The association between daily mortality and ambient air particle pollution in Montreal, Quebec. 1. Nonaccidental mortality. , 2001, Environmental research.

[31]  R. Burnett,et al.  The Effect of Concurvity in Generalized Additive Models Linking Mortality to Ambient Particulate Matter , 2003, Epidemiology.

[32]  Anthony L Bertapelle Spectral Analysis of Time Series. , 1979 .

[33]  M. Alderson,et al.  Accuracy of diagnosis on death certificates compared with that in hospital records. , 1967, British journal of preventive & social medicine.

[34]  J. Brook,et al.  Temporal and spatial relationships in fine particle strong acidity, sulphate, PM1O, and PM2.5 across multiple canadian locations , 1997 .

[35]  E G Luebeck,et al.  Particulate air pollution and mortality. , 1996, Epidemiology.

[36]  R. Tibshirani,et al.  Generalized Additive Models , 1991 .

[37]  R. Burnett,et al.  The Relationship Among TSP, PM10, PM2.5, and Inorganic Constituents of Atmospheric Participate Matter at Multiple Canadian Locations , 1997 .

[38]  J. Goldsmith,et al.  AIR POLLUTION AND DAILY MORTALITY , 1961, The American journal of the medical sciences.

[39]  J. Schwartz Particulate air pollution and daily mortality: a synthesis. , 1991, Public health reviews.

[40]  H. R. Anderson,et al.  Daily time series for cardiovascular hospital admissions and previous day's air pollution in London, UK. , 1997, Occupational and environmental medicine.

[41]  C. Tankersley,et al.  Air pollution and daily mortality: a hypothesis concerning the role of impaired homeostasis. , 2001, Environmental health perspectives.

[42]  C. Percy,et al.  Accuracy of cancer death certificates and its effect on cancer mortality statistics. , 1981, American journal of public health.

[43]  Halûk Özkaynak,et al.  Relationships between Aerosol Extinction Coefficients Derived from Airport Visual Range Observations and Alternative Measures of Airborne Particle Mass , 1985 .

[44]  R. Burnett,et al.  Identifying subgroups of the general population that may be susceptible to short-term increases in particulate air pollution: a time-series study in Montreal, Quebec. , 2000, Research report.

[45]  J. Schwartz,et al.  Air Pollution and Hospital Admissions for Cardiovascular Disease in Tucson , 1997, Epidemiology.

[46]  M. Goldberg Particulate air pollution and daily mortality: who is at risk? , 1996, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[47]  U. de Faire,et al.  A validation of cause-of-death certification in 1,156 deaths. , 2009, Acta medica Scandinavica.

[48]  J. Schwartz,et al.  Air pollution and daily mortality: a review and meta analysis. , 1994, Environmental research.