Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth.
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B. Thébaud | R. Ertsey | M. Nicolls | M. Rabinovitch | B. Starcher | A. Hilgendorff | Kakoli Parai | Noopur Jain | Edwin F. Navarro | Rasa Tamosiuniene | R. Bland | G. Juliana Rey-Parra | G. Rey-Parra | Anne Hilgendorff
[1] John D. Johnson,et al. Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance. , 2015, The American review of respiratory disease.
[2] D. Cornfield,et al. Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization. , 2012, American journal of physiology. Lung cellular and molecular physiology.
[3] R. Ertsey,et al. Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice. , 2011, American journal of respiratory and critical care medicine.
[4] D. Rifkin,et al. Control of lung development by latent TGF‐β binding proteins , 2011, Journal of cellular physiology.
[5] A. Majumdar,et al. Mechanical forces regulate elastase activity and binding site availability in lung elastin. , 2010, Biophysical journal.
[6] H. von Melchner,et al. Dual functions for LTBP in lung development: LTBP‐4 independently modulates elastogenesis and TGF‐β activity , 2009, Journal of cellular physiology.
[7] A. Majumdar,et al. Differential effects of static and cyclic stretching during elastase digestion on the mechanical properties of extracellular matrices. , 2007, Journal of applied physiology.
[8] R. Ertsey,et al. Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice. , 2007, American journal of physiology. Lung cellular and molecular physiology.
[9] K. Csiszȧr,et al. Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease. , 2007, American journal of physiology. Lung cellular and molecular physiology.
[10] B. Thébaud,et al. Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease. , 2007, American journal of respiratory and critical care medicine.
[11] W. Seeger,et al. Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. , 2007, American journal of physiology. Lung cellular and molecular physiology.
[12] M. Butler,et al. Elafin Prevents Lipopolysaccharide-induced AP-1 and NF-κB Activation via an Effect on the Ubiquitin-Proteasome Pathway* , 2006, Journal of Biological Chemistry.
[13] R. Yasumatsu,et al. SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia. , 2006, American journal of physiology. Lung cellular and molecular physiology.
[14] K. Chung,et al. Neutrophil-Derived Elastase Induces TGF-β1 Secretion in Human Airway Smooth Muscle via NF-κB Pathway , 2006 .
[15] A. M. Houghton,et al. Elastin fragments drive disease progression in a murine model of emphysema. , 2006, The Journal of clinical investigation.
[16] R. Pierce,et al. Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia. , 2006, American journal of respiratory and critical care medicine.
[17] M. Maurel,et al. Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase. , 2005, Biochemistry.
[18] G. Haddad,et al. Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia? , 2004, American journal of respiratory cell and molecular biology.
[19] D. Ravi,et al. Increased apoptosis and expression of p21 and p53 in premature infant baboon model of bronchopulmonary dysplasia. , 2004, Antioxidants & redox signaling.
[20] Peter P. Liu,et al. Elafin-overexpressing mice have improved cardiac function after myocardial infarction. , 2004, American journal of physiology. Heart and circulatory physiology.
[21] M. Nugent,et al. Elastase mediates the release of growth factors from lung in vivo. , 2004, American journal of respiratory cell and molecular biology.
[22] D. Webb,et al. Adenoviral Gene Delivery of Elafin and Secretory Leukocyte Protease Inhibitor Attenuates NF-κB-Dependent Inflammatory Responses of Human Endothelial Cells and Macrophages to Atherogenic Stimuli1 , 2004, The Journal of Immunology.
[23] D. Warburton,et al. Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. , 2003, The American journal of pathology.
[24] C. Haslett,et al. Regulation of Pulmonary and Systemic Bacterial Lipopolysaccharide Responses in Transgenic Mice Expressing Human Elafin , 2003, Infection and Immunity.
[25] K. Aoshiba,et al. Alveolar wall apoptosis causes lung destruction and emphysematous changes. , 2003, American journal of respiratory cell and molecular biology.
[26] M. Haniuda,et al. Serine protease inhibitors modulate chemotactic cytokine production by human lung fibroblasts in vitro. , 2003, American journal of physiology. Lung cellular and molecular physiology.
[27] M. Husain,et al. Overexpression of the Serine Elastase Inhibitor Elafin Protects Transgenic Mice From Hypoxic Pulmonary Hypertension , 2002, Circulation.
[28] D. Porteous,et al. Adenoviral Augmentation of Elafin Protects the Lung Against Acute Injury Mediated by Activated Neutrophils and Bacterial Infection1 , 2001, The Journal of Immunology.
[29] B. Szende,et al. Apoptosis in Various Organs of Preterm Infants: Histopathologic Study of Lung, Kidney, Liver, and Brain of Ventilated Infants , 2001, Pediatric Research.
[30] W. Truog,et al. Lung elastic tissue maturation and perturbations during the evolution of chronic lung disease. , 2000, Pediatrics.
[31] R. Bland,et al. Chronic Lung Disease in Early Infancy , 2000 .
[32] M. Keating,et al. Impaired distal airway development in mice lacking elastin. , 2000, American journal of respiratory cell and molecular biology.
[33] D. Carlton,et al. Chronic Lung Injury in Preterm Lambs: Abnormalities of the Pulmonary Circulation and Lung Fluid Balance , 2000, Pediatric Research.
[34] M. Rabinovitch,et al. Suppressed smooth muscle proliferation and inflammatory cell invasion after arterial injury in elafin-overexpressing mice. , 2000, The Journal of clinical investigation.
[35] A. Jobe. The New BPD: An Arrest of Lung Development , 1999, Pediatric Research.
[36] B. Yoder,et al. Neonatal chronic lung disease in extremely immature baboons. , 1999, American journal of respiratory and critical care medicine.
[37] M. Rabinovitch,et al. Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. , 1999, The Journal of clinical investigation.
[38] D. Carlton,et al. Chronic lung injury in preterm lambs. Disordered respiratory tract development. , 1999, American journal of respiratory and critical care medicine.
[39] P. Jones,et al. AML1-like transcription factor induces serine elastase activity in ovine pulmonary artery smooth muscle cells. , 1998, Circulation research.
[40] A. Husain,et al. Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia. , 1998, Human pathology.
[41] Dean Y. Li,et al. Elastin is an essential determinant of arterial morphogenesis , 1998, Nature.
[42] D. Cox,et al. α1-Proteinase Inhibitor Therapy for the Prevention of Chronic Lung Disease of Prematurity: A Randomized, Controlled Trial , 1998, Pediatrics.
[43] R. Pierce,et al. Chronic lung injury in preterm lambs: disordered pulmonary elastin deposition. , 1997, The American journal of physiology.
[44] G. Wilson,et al. Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation. , 1996, The Journal of clinical investigation.
[45] M. Rabinovitch,et al. Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix‐bound basic fibroblast growth factor , 1996, Journal of cellular physiology.
[46] Y. Itoh,et al. Preferential Inactivation of Tissue Inhibitor of Metalloproteinases-1 That Is Bound to the Precursor of Matrix Metalloproteinase 9 (Progelatinase B) by Human Neutrophil Elastase (*) , 1995, The Journal of Biological Chemistry.
[47] K. Watterberg,et al. Secretory leukocyte protease inhibitor and lung inflammation in developing bronchopulmonary dysplasia. , 1994, The Journal of pediatrics.
[48] Y. Suzuki,et al. Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed "cementoin". , 1994, Journal of biochemistry.
[49] J. Sallenave,et al. Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions. , 1993, American journal of respiratory cell and molecular biology.
[50] J. Sallenave,et al. Secretion of mucus proteinase inhibitor and elafin by Clara cell and type II pneumocyte cell lines. , 1993, American journal of respiratory cell and molecular biology.
[51] S. McGowan. Influences of endogenous and exogenous TGF-beta on elastin in rat lung fibroblasts and aortic smooth muscle cells. , 1992, The American journal of physiology.
[52] J. Tomashefski,et al. Risk factors for the degradation of lung elastic fibers in the ventilated neonate. Implications for impaired lung development in bronchopulmonary dysplasia. , 1992, The American review of respiratory disease.
[53] J. Tomashefski,et al. Morphometric analysis of the lung in bronchopulmonary dysplasia. , 1991, The American review of respiratory disease.
[54] J. Wigglesworth,et al. The effects of preterm delivery and mechanical ventilation on human lung growth. , 1987, Early human development.
[55] A. Fanaroff,et al. Altered urinary excretion of elastin cross-links in premature infants who develop bronchopulmonary dysplasia. , 1985, The American review of respiratory disease.
[56] D. Strayer,et al. Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia. , 1983, The Journal of clinical investigation.
[57] W. Scherle,et al. A simple method for volumetry of organs in quantitative stereology. , 1970, Mikroskopie.
[58] W. Northway,et al. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. , 1967, The New England journal of medicine.
[59] J. Emery,et al. The Number of Alveoli in the Terminal Respiratory Unit of Man During Late Intrauterine Life and Childhood , 1960, Archives of disease in childhood.
[60] R. Ertsey,et al. Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. , 2010, American journal of physiology. Lung cellular and molecular physiology.
[61] D. Rifkin,et al. Growth Factors , Cytokines , Cell Cycle Molecules Lung Alveolar Septation Defects in Ltbp-3-Null Mice , 2010 .
[62] R. Ertsey,et al. Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development? , 2008, American journal of physiology. Lung cellular and molecular physiology.
[63] J. Coalson. 5. PATHOLOGY OF CHRONIC LUNG DISEASE OF EARLY INFANCY , 2000 .
[64] B. Starcher,et al. Measurement of urinary desmosine as an indicator of acute pulmonary disease. , 1995, Respiration; international review of thoracic diseases.
[65] Q. Lu,et al. Transforming growth factor- (cid:1) 1 causes pulmonary microvascular endothelial cell apoptosis via ALK5 , 2022 .