1 Interplay between Vascular Endothelial Growth Factor ( VEGF ) and the Nuclear factor erythroid 2-related factor-2 ( Nrf 2 ) : implications for preeclampsia *

Background: Several studies have suggested that decreasing VEGF levels might result in placental oxidative stress in preeclampsia. Results: VEGF activates Nrf2 in an ERK1/2dependent manner protecting against oxidative stress and, in turn, up-regulates VEGF expression. Conclusions: Reduced VEGF bioavailability may lead to aggregation of oxidative stress and end up in preeclampsia. Significance: Nrf2 activation might be considered as an adjunct therapeutic strategy to combat preeclampsia.