Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals

Monitoring (currently invasive) of cerebral venous blood oxygenation is a key to avoiding hypoxia-induced brain injury resulting in death or severe disability. Noninvasive, optoacoustic monitoring of cerebral venous blood oxygenation can potentially replace existing invasive methods. To the best of our knowledge, we report for the first time noninvasive monitoring of cerebral venous blood oxygenation through intact scalp that was validated with invasive, “gold standard” measurements. We performed an in vivo study in the sheep superior sagittal sinus (SSS), a large midline cerebral vein, using our novel, multi-wavelength optoacoustic system. The study results demonstrated that: 1) the optoacoustic signal from the sheep SSS is detectable through the thick, intact scalp and skull; 2) the SSS signal amplitude correlated well with wavelength and actual SSS blood oxygenation measured invasively using SSS catheterization, blood sampling, and measurement with “gold standard” CO-Oximeter; 3) the optoacoustically predicted oxygenation strongly correlated with that measured with the CO-Oximeter. Our results indicate that monitoring of cerebral venous blood oxygenation may be performed in humans noninvasively and accurately through the intact scalp using optoacoustic systems because the sheep scalp and skull thickness is comparable to that of humans whereas the sheep SSS is much smaller than that of humans.

[1]  G. M. Hale,et al.  Optical Constants of Water in the 200-nm to 200-microm Wavelength Region. , 1973, Applied optics.

[2]  J. Barger,et al.  Acoustical properties of the human skull. , 1978, The Journal of the Acoustical Society of America.

[3]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[4]  R G Grossman,et al.  Jugular venous desaturation and outcome after head injury. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[5]  Britton Chance,et al.  Near-infrared Measurement of Cerebral Oxygenation: Correlation with Electroencephalographic Ischemia during Ventricular Fibrillation , 1995, Anesthesiology.

[6]  D. Prough,et al.  The Influence of Carbon Dioxide and Body Position on Near-Infrared Spectroscopic Assessment of Cerebral Hemoglobin Oxygen Saturation , 1996, Anesthesia and analgesia.

[7]  D. Prough,et al.  Validation in Volunteers of a Near-Infrared Spectroscope for Monitoring Brain Oxygenation In Vivo , 1996, Anesthesia and analgesia.

[8]  W. Dunn Principles and Practice of Intensive Care Monitoring , 1998 .

[9]  John D. Enderle,et al.  Introduction to Biomedical Engineering , 1999 .

[10]  Kirill V. Larin,et al.  Optoacoustic Technique for Non-invasive Continuous Monitoring of Blood Oxygenation , 2000 .

[11]  V. Tuchin Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis , 2000 .

[12]  Massoud Motamedi,et al.  Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study. , 2002, Applied optics.

[13]  D. Prough,et al.  In vivo noninvasive monitoring of cerebral blood oxygenation with optoacoustic technique , 2004, EMBC 2004.

[14]  Martin Wolf,et al.  Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach. , 2004, Journal of biomedical optics.

[15]  Massoud Motamedi,et al.  Optoacoustic, Noninvasive, Real-Time, Continuous Monitoring of Cerebral Blood Oxygenation: An In Vivo Study in Sheep , 2005, Anesthesiology.

[16]  D. Prough,et al.  Multiwavelength optoacoustic system for noninvasive monitoring of cerebral venous oxygenation: a pilot clinical test in the internal jugular vein. , 2006, Optics letters.

[17]  Paola Taroni,et al.  Time-resolved diffuse optical spectroscopy of small tissue samples , 2007, European Conference on Biomedical Optics.

[18]  Geoffrey T. Manley,et al.  X. Brain Oxygen Monitoring and Thresholds , 2007 .

[19]  David W Wright,et al.  Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation. , 2007, Journal of neurotrauma.

[20]  David W Wright,et al.  Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds. , 2007, Journal of neurotrauma.

[21]  David W Wright,et al.  Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds. , 2007, Journal of neurotrauma.

[22]  Geoffrey T. Manley,et al.  I. Blood Pressure and Oxygenation , 2007 .

[23]  Geoffrey T. Manley,et al.  IX. Cerebral Perfusion Thresholds , 2007 .

[24]  D. Prough,et al.  In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system. , 2007, Optics express.

[25]  Donald S. Prough,et al.  Clinical tests of highly portable 2-lb. laser diode-based noninvasive optoacoustic hemoglobin monitor , 2009, BiOS.

[26]  D. Prough,et al.  Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system. , 2009, Optics express.

[27]  Donald S. Prough,et al.  Novel optoacoustic array for noninvasive monitoring of blood parameters , 2009, BiOS.

[28]  Vladimir P Zharov,et al.  In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laser. , 2009, Cancer research.

[29]  Vasilis Ntziachristos,et al.  Real-time imaging of cardiovascular dynamics and circulating gold nanorods with multispectral optoacoustic tomography. , 2010, Optics express.

[30]  Wiendelt Steenbergen,et al.  Passive element enriched photoacoustic computed tomography (PER PACT) for simultaneous imaging of acoustic propagation properties and light absorption. , 2011, Optics express.

[31]  P. Burgholzer,et al.  Piezoelectric annular array for large depth of field photoacoustic imaging , 2011, Biomedical optics express.

[32]  I. Y. Petrov,et al.  Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood , 2011, Biomedical optics express.