Tranexamic acid is safe and effective in patients with heterozygous factor V Leiden mutation during total joint arthroplasty

[1]  S. Kahn,et al.  What’s new in VTE risk and prevention in orthopedic surgery , 2020, Research and practice in thrombosis and haemostasis.

[2]  H. Kehlet,et al.  Venous Thromboembolism despite Ongoing Prophylaxis after Fast-Track Hip and Knee Arthroplasty: A Prospective Multicenter Study of 34,397 Procedures , 2019, Thrombosis and Haemostasis.

[3]  A. Spaulding,et al.  Tranexamic Acid Administration Is Not Associated With an Increase in Complications in High-Risk Patients Undergoing Primary Total Knee or Total Hip Arthroplasty: A Retrospective Case-Control Study of 38,220 Patients. , 2019, The Journal of arthroplasty.

[4]  A. Peitzman,et al.  Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism , 2019, The journal of trauma and acute care surgery.

[5]  A. Natarajan,et al.  Genetics of Hypercoagulable and Hypocoagulable States. , 2018, Neurosurgery clinics of North America.

[6]  D. Jevsevar,et al.  Tranexamic Acid Use in Total Joint Arthroplasty: The Clinical Practice Guidelines Endorsed by the American Association of Hip and Knee Surgeons, American Society of Regional Anesthesia and Pain Medicine, American Academy of Orthopaedic Surgeons, Hip Society, and Knee Society. , 2018, The Journal of arthroplasty.

[7]  L. Shields,et al.  Xanthine calculi in a patient with Lesch-Nyhan syndrome and factor V Leiden treated with allopurinol: case report , 2018, BMC Pediatrics.

[8]  E. Elster,et al.  Evaluation of Military Use of Tranexamic Acid and Associated Thromboembolic Events , 2017, JAMA surgery.

[9]  Haley M. Phillippe.  Overview of venous thromboembolism. , 2017, The American journal of managed care.

[10]  K. Park,et al.  Management of Blood Loss in Hip Arthroplasty: Korean Hip Society Current Consensus , 2017, Hip & pelvis.

[11]  A. Anand,et al.  Tranexamic Acid in Hip and Knee Arthroplasty. , 2016, The Journal of the American Academy of Orthopaedic Surgeons.

[12]  R. Sierra,et al.  Tranexamic Acid in Hip and Knee Arthroplasty , 2015, Journal of the American Academy of Orthopaedic Surgeons.

[13]  M. Rosin,et al.  Factor V Leiden and Cardiopulmonary Bypass. , 2015, The journal of extra-corporeal technology.

[14]  Daniel A. Charen,et al.  Risk Factors for Postoperative Venous Thromboembolism in Orthopaedic Spine Surgery, Hip Arthroplasty, and Knee Arthroplasty Patients. , 2015, Bulletin of the Hospital for Joint Disease.

[15]  F. Haddad,et al.  A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. , 2014, The bone & joint journal.

[16]  M. Pagnano,et al.  Preliminary Results Suggest Tranexamic Acid is Safe and Effective in Arthroplasty Patients with Severe Comorbidities , 2014, Clinical orthopaedics and related research.

[17]  F. Haddad,et al.  Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. , 2011, The Journal of bone and joint surgery. British volume.

[18]  K. Szepesi,et al.  Assessment of thrombotic risk factors predisposing to thromboembolic complications in prosthetic orthopedic surgery , 2009, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[19]  G. Berlin,et al.  Validation of a haemoglobin dilution method for estimation of blood loss , 2008, Vox sanguinis.

[20]  T. Lindahl,et al.  Factor V Leiden (G1691A) and Prothrombin Gene G20210A Mutations as Potential Risk Factors for Venous Thromboembolism after Total Hip or Total Knee Replacement Surgery , 2002, Thrombosis and Haemostasis.

[21]  P. D. Di Cesare,et al.  The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty , 2001, BMC musculoskeletal disorders.

[22]  Comparison of thrombotic risk between 85 homozygotes and 481 heterozygotes carriers of the factor V Leiden mutation: retrospective analysis from the Procare Study , 2000, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[23]  T. Lindahl,et al.  APC-resistance Is a Risk Factor for Postoperative Thromboembolism in Elective Replacement of the Hip or Knee – A Prospective Study , 1999, Thrombosis and Haemostasis.

[24]  W. Bargar,et al.  Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty. , 1998, Archives of internal medicine.

[25]  C. Francis,et al.  Relation of Factor V Leiden Genotype to Risk for Acute Deep Venous Thrombosis after Joint Replacement Surgery , 1998, Annals of Internal Medicine.

[26]  W. Maloney,et al.  Factor V Leiden and the risk of proximal venous thrombosis after total hip arthroplasty. , 1998, The Journal of arthroplasty.

[27]  S. Nadler,et al.  Prediction of blood volume in normal human adults. , 1962, Surgery.