Method and apparatus for measuring the cerebral perfusion

A method for measuring the cerebral perfusion of a patient (8) provided with the following steps: continuous long-term derivation and storage of an EEG signal (E) of the patient (8); Cleanup of the EEG signal (E) of artifacts; Power spectral analysis of the artifact adjusted EEG signal in certain frequency bands; Cleanup of the tracks obtained by the Power spectral analysis about a common trend of all the tracks; Detecting deviations (D) of the detrended power values ​​of at least one track of a baseline; and display of significant deviations (D) and / or triggering of an alarm (A) if a significant deviation is detected (D). An associated apparatus (1) comprises an EEG device (2) and a data communication so technically-connected control unit (3) which is adapted for automatically performing the method.

[1]  W. Dong,et al.  Effects of intravenous human albumin and furosemide on EEG recordings in patients with intracerebral hemorrhage , 2002, Clinical Neurophysiology.

[2]  S. Selvin,et al.  The burden, trends, and demographics of mortality from subarachnoid hemorrhage , 1998, Neurology.

[3]  Jan Claassen,et al.  Frequency and clinical impact of asymptomatic cerebral infarction due to vasospasm after subarachnoid hemorrhage. , 2008, Journal of neurosurgery.

[4]  H. Meiselman,et al.  Correlates of middle cerebral artery blood velocity in the elderly. , 1990, Stroke.

[5]  J. Dreier The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease , 2011, Nature Medicine.

[6]  Stephanie Gollwitzer,et al.  Automatic seizure detection in long-term scalp EEG using an adaptive thresholding technique: A validation study for clinical routine , 2014, Clinical Neurophysiology.

[7]  R. Macdonald,et al.  Cerebral Infarction After Subarachnoid Hemorrhage Contributes to Poor Outcome by Vasospasm-Dependent and -Independent Effects , 2011, Stroke.

[8]  S. Mayer,et al.  Intracortical EEG for the Detection of Vasospasm in Patients with Poor-Grade Subarachnoid Hemorrhage , 2010, Neurocritical care.

[9]  B. Romner,et al.  Nimodipine in aneurysmal subarachnoid hemorrhage: a randomized study of intravenous or peroral administration. , 2009, Journal of neurosurgery.

[10]  A. Rupp,et al.  Quantitative EEG Correlates of Low Cerebral Perfusion in Severe Stroke , 2009, Neurocritical care.

[11]  Y. Aburto-Murrieta,et al.  Endovascular Treatment , 2012, Vascular and endovascular surgery.

[12]  Jan Claassen,et al.  Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage , 2004, Clinical Neurophysiology.

[13]  S. Weigand,et al.  Predictors of Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage , 2004, Stroke.

[14]  W. Dong,et al.  Effects of intravenous mannitol on EEG recordings in stroke patients , 2002, Clinical Neurophysiology.

[15]  Chad M. Miller,et al.  Distribution of delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage and implications for regional neuromonitoring , 2012, Clinical Neurology and Neurosurgery.

[16]  B. Siesjö,et al.  Thresholds in cerebral ischemia - the ischemic penumbra. , 1981, Stroke.

[17]  The effects of hematocrit and age on transcranial Doppler measurements in patients with recent ischemic stroke. , 2005, Neurology India.

[18]  Jan Claassen,et al.  Recommendations on the use of EEG monitoring in critically ill patients: consensus statement from the neurointensive care section of the ESICM , 2013, Intensive Care Medicine.

[19]  W. Youden,et al.  Index for rating diagnostic tests , 1950, Cancer.

[20]  L. Brass,et al.  Transcranial Doppler measurements of the middle cerebral artery. Effect of hematocrit. , 1988, Stroke.

[21]  L. Michels,et al.  Coupling Between Resting Cerebral Perfusion and EEG , 2012, Brain Topography.

[22]  Guy Nagels,et al.  Quantitative EEG in ischemic stroke: Correlation with infarct volume and functional status in posterior circulation and lacunar syndromes , 2011, Clinical Neurophysiology.

[23]  W. Couldwell,et al.  Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. , 2006, Neurosurgical focus.

[24]  Eduardo Aubert,et al.  Assessing Acute Middle Cerebral Artery Ischemic Stroke by Quantitative Electric Tomography , 2004, Clinical EEG and neuroscience.

[25]  M. Treggiari,et al.  Hemodynamic Management of Subarachnoid Hemorrhage , 2011, Neurocritical care.

[26]  S. Mayer,et al.  Angiographic Vasospasm Is Strongly Correlated With Cerebral Infarction After Subarachnoid Hemorrhage , 2011, Stroke.

[27]  M R Nuwer,et al.  Early detection of vasospasm after acute subarachnoid hemorrhage using continuous EEG ICU monitoring. , 1997, Electroencephalography and clinical neurophysiology.

[28]  H. Stefan,et al.  An efficient, robust and fast method for the offline detection of epileptic seizures in long-term scalp EEG recordings , 2007, Clinical Neurophysiology.

[29]  B. Fisch,et al.  Quantitative EEG monitoring for patients with subarachnoid hemorrhage. , 1991, Electroencephalography and clinical neurophysiology.

[30]  J. Philippon,et al.  Value of Electroencephalogram in prediction and diagnosis of vasospasm after intracranial aneurysm rupture , 2005, Acta Neurochirurgica.

[31]  Fisher Cm,et al.  Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. , 1980, Neurosurgery.

[32]  R. Emerson,et al.  Continuous EEG Monitoring in the Intensive Care Unit: Technical and Staffing Considerations , 2005, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[33]  Á. Pascual-Leone,et al.  α-Band Electroencephalographic Activity over Occipital Cortex Indexes Visuospatial Attention Bias and Predicts Visual Target Detection , 2006, The Journal of Neuroscience.

[34]  R. Dhar,et al.  The relationship between delayed infarcts and angiographic vasospasm after aneurysmal subarachnoid hemorrhage. , 2013, Neurosurgery.

[35]  Guy Nagels,et al.  Quantitative EEG in ischemic stroke: Correlation with functional status after 6months , 2011, Clinical Neurophysiology.

[36]  R. Hilker,et al.  Early electroencephalography in acute ischemic stroke: Prediction of a malignant course? , 2007, Clinical Neurology and Neurosurgery.

[37]  G. B. Young,et al.  EEG monitoring in the intensive care unit: pitfalls and caveats. , 1999, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[38]  J. Gotman,et al.  Using Continuous Electroencephalography in the Management of Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage , 2011, Neurocritical care.