Refining precision immunotherapy
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Two studies show why some, but not all, MMR-deficient tumors are sensitive to immunotherapy. Two studies show why some, but not all, MMR-deficient tumors are sensitive to immunotherapy.
[1] M. Gerlinger. Immunotherapy Sensitivity of Mismatch Repair-Deficient Cancer: Mutation Load Is Not Enough. , 2021, Cancer cell.
[2] A. Davis,et al. MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway. , 2020, Cancer cell.
[3] Tao Wang,et al. DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity. , 2020, Cancer cell.